Reactome | Dengue polyprotein cis-auto-cleaves

Schema > Reaction > Entries

Dengue polyprotein cis-auto-cleaves Show undefined attributes

authored	[InstanceEdit:9918832] Stephan, Ralf, 2024-08-18
catalystActivity	[CatalystActivity:9918822] serine-type endopeptidase activity of folded HyPro-Polyprotein [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9918778] Stephan, Ralf, 2024-08-18
crossReference	[DatabaseIdentifier:12020825] Mondo:0005502
dbId	9918772
disease	[Disease:3244610] dengue disease
displayName	Dengue polyprotein cis-auto-cleaves
edited	[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
eventOf	[Pathway:R-HSA-9918432] Maturation of DENV proteins - Homo sapiens
followingEvent	[Reaction:R-HSA-9920882] NS2B binds CGAS - Homo sapiens [BlackBoxEvent:R-HSA-9918787] NS2B3 cleaves C-prM-E-NS1-NS2A - Homo sapiens [Reaction:R-HSA-9918807] NS2B binds NS3 - Homo sapiens [Reaction:R-HSA-9918798] NS2B binds to NS345 - Homo sapiens [Reaction:R-HSA-9918823] NS345:NS2B cleaves NS345 - Homo sapiens [Reaction:R-HSA-9947496] ACOT2 cleaves NS345 - Homo sapiens [BlackBoxEvent:R-HSA-9920087] Nonstructural proteins form the replication complex - Homo sapiens
input	[EntityWithAccessionedSequence:R-DVI-9918800] folded HyPro-Polyprotein [endoplasmic reticulum membrane] 2 × [SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9918765] Processing of nonstructural proteins NS4A and NS4B of dengue 2 virus in vitro and in vivo [LiteratureReference:9918797] Cleavage preference distinguishes the two-component NS2B-NS3 serine proteinases of Dengue and West Nile viruses [LiteratureReference:9918766] Processing of flavivirus structural glycoproteins: stable membrane insertion of premembrane requires the envelope signal peptide [LiteratureReference:9920139] Functional characterization of cis and trans activity of the Flavivirus NS2B-NS3 protease [LiteratureReference:9966315] In vitro processing of dengue virus type 2 nonstructural proteins NS2A, NS2B, and NS3
maxDepth	1
modified	[InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
name	Dengue polyprotein cis-auto-cleaves
output	[EntityWithAccessionedSequence:R-DVI-9918791] C-prM-E-NS12A [endoplasmic reticulum membrane] [EntityWithAccessionedSequence:R-DVI-9918774] NS2B [endoplasmic reticulum membrane] [EntityWithAccessionedSequence:R-DVI-9918829] NS345 [endoplasmic reticulum membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9918810] HyPro-polyprotein folds - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
relatedSpecies	[Species:3244621] Dengue virus type 2
releaseDate	2025-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18 [InstanceEdit:9970439] Roque Ascen��o, Fernando, 2025-10-29
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9918772
summation	[Summation:9920010] The NS3 peptidase domain of the folded Dengue virus polyprot...

Referrals

(precedingEvent)	[Reaction:R-HSA-9920882] NS2B binds CGAS [Reaction:R-HSA-9918823] NS345:NS2B cleaves NS345 [BlackBoxEvent:R-HSA-9918787] NS2B3 cleaves C-prM-E-NS1-NS2A [Reaction:R-HSA-9918807] NS2B binds NS3 [Reaction:R-HSA-9918798] NS2B binds to NS345 [Reaction:R-HSA-9947496] ACOT2 cleaves NS345 [BlackBoxEvent:R-HSA-9920087] Nonstructural proteins form the replication complex
(hasEvent)	[Pathway:R-HSA-9918432] Maturation of DENV proteins

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