Reactome | DENV mRNA is decapped

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DENV mRNA is decapped Show undefined attributes

authored	[InstanceEdit:9946666] Stephan, Ralf, 2025-04-27
catalystActivity	[CatalystActivity:9946786] RNA exonuclease activity, producing 5'-phosphomonoesters of Unknown enzyme [cytosol]
category	uncertain
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9946773] Stephan, Ralf, 2025-04-28
crossReference	[DatabaseIdentifier:12020825] Mondo:0005502
dbId	9946784
disease	[Disease:3244610] dengue disease
displayName	DENV mRNA is decapped
edited	[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
eventOf	[Pathway:R-HSA-9918487] Dengue Virus Genome Translation and Replication - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9946917] XRN1 incompletely hydrolyzes DENV decapped mRNA - Homo sapiens [BlackBoxEvent:R-HSA-9947387] Exosomal secretion of DENV RNA and proteins - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:9666324] mRNA methylguanosine-cap decapping
input	[EntityWithAccessionedSequence:R-DVI-9922609] DENV m7G(5')pppAm-capped genomic +ssRNA [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9946903] RNA structures that resist degradation by Xrn1 produce a pathogenic Dengue virus RNA
maxDepth	1
modified	[InstanceEdit:9975896] Stephan, Ralf, 2025-12-03
name	DENV mRNA is decapped
negativePrecedingEvent	[NegativePrecedingEvent:9960008] Negative relationship: NS5 synthesizes minus strand genome
output	[EntityWithAccessionedSequence:R-DVI-9946776] DENV decapped mRNA [cytosol]
precedingEvent	[Reaction:R-HSA-9923094] DENV capped genome (+)-RNA dissociates from RC - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
relatedSpecies	[Species:3244621] Dengue virus type 2
releaseDate	2025-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18 [InstanceEdit:9970439] Roque Ascen��o, Fernando, 2025-10-29
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9946784
summation	[Summation:9946779] Since it has been established that DENV RNA can undergo degr...

Referrals

(hasEvent)	[Pathway:R-HSA-9918487] Dengue Virus Genome Translation and Replication
(precedingEvent)	[BlackBoxEvent:R-HSA-9947387] Exosomal secretion of DENV RNA and proteins [BlackBoxEvent:R-HSA-9946917] XRN1 incompletely hydrolyzes DENV decapped mRNA

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