Reactome | NS2B binds NS3

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NS2B binds NS3 Show undefined attributes

authored	[InstanceEdit:9918832] Stephan, Ralf, 2024-08-18
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9918778] Stephan, Ralf, 2024-08-18
crossReference	[DatabaseIdentifier:12020825] Mondo:0005502
dbId	9918807
disease	[Disease:3244610] dengue disease
displayName	NS2B binds NS3
edited	[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
eventOf	[Pathway:R-HSA-9918432] Maturation of DENV proteins - Homo sapiens
followingEvent	[Reaction:R-HSA-9921160] NS2B3 binds NFKBIB - Homo sapiens [Reaction:R-HSA-9921595] NS2B3 cleaves FAM134B - Homo sapiens [Reaction:R-HSA-9921168] NS2B3 binds NFKBIA - Homo sapiens [Reaction:R-HSA-9920952] NS2B3 binds IKBKE - Homo sapiens [Reaction:R-HSA-3244618] DENV protease NS2B3 binds STING - Homo sapiens [BlackBoxEvent:R-HSA-9945387] NS2B3 localizes to nucleus - Homo sapiens [Reaction:R-HSA-9954667] NS2B3 binds Dengue protease inhibitors - Homo sapiens [Reaction:R-HSA-9918813] NS2B3 cleaves NS4AB - Homo sapiens [Reaction:R-HSA-9918817] NS2B3 cleaves polyprotein - Homo sapiens [Reaction:R-HSA-9918876] NS2B3 cleaves prepro-C at the C-prM junction - Homo sapiens [BlackBoxEvent:R-HSA-9918787] NS2B3 cleaves C-prM-E-NS1-NS2A - Homo sapiens
input	[EntityWithAccessionedSequence:R-DVI-3244645] K27polyUb-NS3 [endoplasmic reticulum membrane] [EntityWithAccessionedSequence:R-DVI-9918774] NS2B [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9919960] Pharmacophoric characteristics of dengue virus NS2B/NS3pro inhibitors: a systematic review of the most promising compounds [LiteratureReference:9919957] Both nonstructural proteins NS2B and NS3 are required for the proteolytic processing of dengue virus nonstructural proteins [LiteratureReference:9920097] Ligand-bound structures of the dengue virus protease reveal the active conformation [LiteratureReference:9920018] Biochemistry and medicinal chemistry of the dengue virus protease [LiteratureReference:9945287] Differential localization of dengue virus protease affects cell homeostasis and triggers to thrombocytopenia [LiteratureReference:9949470] Potential Role of Flavivirus NS2B-NS3 Proteases in Viral Pathogenesis and Anti-flavivirus Drug Discovery Employing Animal Cells and Models: A Review
maxDepth	1
modified	[InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
name	NS2B binds NS3
output	[Complex:R-DVI-3244638] NS2B3 [cytosol]
precedingEvent	[Reaction:R-HSA-9918817] NS2B3 cleaves polyprotein - Homo sapiens [Reaction:R-HSA-9918772] Dengue polyprotein cis-auto-cleaves - Homo sapiens [Reaction:R-HSA-9918823] NS345:NS2B cleaves NS345 - Homo sapiens [BlackBoxEvent:R-HSA-9945766] NS3 is ubiquitinated - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
relatedSpecies	[Species:3244621] Dengue virus type 2
releaseDate	2025-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18 [InstanceEdit:9970439] Roque Ascen��o, Fernando, 2025-10-29
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9918807
summation	[Summation:9920000] Dengue virus proteins NS2B and NS3 bind non-covalently. The ...

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(hasEvent)

[Pathway:R-HSA-9918432] Maturation of DENV proteins

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