Reactome | Cap-dependent translation of DENV genomic RNA

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Cap-dependent translation of DENV genomic RNA Show undefined attributes

authored	[InstanceEdit:9918832] Stephan, Ralf, 2024-08-18
category	uncertain
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9947227] Stephan, Ralf, 2025-05-03
crossReference	[DatabaseIdentifier:12020825] Mondo:0005502
dbId	9947230
disease	[Disease:3244610] dengue disease
displayName	Cap-dependent translation of DENV genomic RNA
edited	[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
eventOf	[Pathway:R-HSA-9918487] Dengue Virus Genome Translation and Replication - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9923067] Nascent polyprotein starts folding in ER - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:6668] viral translation
input	[EntityWithAccessionedSequence:R-DVI-9922609] DENV m7G(5')pppAm-capped genomic +ssRNA [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9923529] Flavors of Flaviviral RNA Structure: towards an Integrated View of RNA Function from Translation through Encapsidation [LiteratureReference:9947239] Protein Synthesis Initiation in Eukaryotic Cells [LiteratureReference:9947231] The Organizing Principles of Eukaryotic Ribosome Recruitment [LiteratureReference:9947247] Dengue virus utilizes a novel strategy for translation initiation when cap-dependent translation is inhibited [LiteratureReference:9947236] Dengue and Zika Virus 5' Untranslated Regions Harbor Internal Ribosomal Entry Site Functions [LiteratureReference:9947238] The internal ribosome entry site of the Dengue virus mRNA is active when cap-dependent translation initiation is inhibited [LiteratureReference:9947254] Enhancement of dengue virus translation: role of the 3' untranslated region and the terminal 3' stem-loop domain [LiteratureReference:9922931] Control of dengue virus translation and replication [LiteratureReference:9947255] Biochemistry and Molecular Biology of Flaviviruses [LiteratureReference:9925626] The flavivirus polymerase NS5 regulates translation of viral genomic RNA [LiteratureReference:9947560] Characterization of RyDEN (C19orf66) as an Interferon-Stimulated Cellular Inhibitor against Dengue Virus Replication [LiteratureReference:9947589] Hyperglycemia exacerbates dengue virus infection by facilitating poly(A)-binding protein-mediated viral translation [LiteratureReference:9947599] Poly(A)-binding protein binds to the non-polyadenylated 3' untranslated region of dengue virus and modulates translation efficiency [LiteratureReference:9947597] NF90 binds the dengue virus RNA 3' terminus and is a positive regulator of dengue virus replication [LiteratureReference:9947670] Y box-binding protein-1 binds to the dengue virus 3'-untranslated region and mediates antiviral effects [LiteratureReference:9947723] Quantitative mass spectrometry of DENV-2 RNA-interacting proteins reveals that the DEAD-box RNA helicase DDX6 binds the DB1 and DB2 3' UTR structures [LiteratureReference:9947724] Identification of host factors binding to dengue and Zika virus subgenomic RNA by efficient yeast three-hybrid screens of the human ORFeome [LiteratureReference:9946548] Circularization of flavivirus genomic RNA inhibits de novo translation initiation [LiteratureReference:9948245] An RNA-centric dissection of host complexes controlling flavivirus infection [LiteratureReference:9948249] HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins [LiteratureReference:9954464] Identification of Proteins Bound to Dengue Viral RNA In Vivo Reveals New Host Proteins Important for Virus Replication
maxDepth	1
modified	[InstanceEdit:9971555] Stephan, Ralf, 2025-11-07
name	Cap-dependent translation of DENV genomic RNA
output	[EntityWithAccessionedSequence:R-DVI-9947246] Nascent polyprotein [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9922491] Dengue virion releases its genome - Homo sapiens [BlackBoxEvent:R-HSA-9947465] Import of DENV RNA from exosomes - Homo sapiens [Reaction:R-HSA-9923094] DENV capped genome (+)-RNA dissociates from RC - Homo sapiens
regulatedBy	[Requirement:9947228] Requirement by 'EIF4F [cytosol]' [NegativeRegulation:9947303] Negative regulation by 'NS5 [endoplasmic reticulum membrane]' [Requirement:9947586] Requirement by 'PABPC1 [cytosol]' [NegativeRegulation:9947679] Negative regulation by 'YBX1:DENV mRNA [cytosol]' [NegativeRegulation:9947760] Negative regulation by 'DENV circular genomic +ssRNA:RC [endoplasmic reticulum membrane]' [PositiveRegulation:9948221] Positive regulation by 'HDBLP:RRBP1:DENV mRNA [endoplasmic reticulum membrane]'
relatedSpecies	[Species:3244621] Dengue virus type 2
releaseDate	2025-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18 [InstanceEdit:9970439] Roque Ascen��o, Fernando, 2025-10-29
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9947230
summation	[Summation:9947240] Host ribosomes translate the capped DENV genomic RNA, produc...
updateTrackers	[UpdateTracker:9984645] Update Tracker - [BlackBoxEvent:9947230] Cap-dependent translation of DENV genomic RNA - v96:[add_removeRegulator]

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-9923067] Nascent polyprotein starts folding in ER
(hasEvent)	[Pathway:R-HSA-9918487] Dengue Virus Genome Translation and Replication
(updatedInstance)	[UpdateTracker:9984645] Update Tracker - [BlackBoxEvent:9947230] Cap-dependent translation of DENV genomic RNA - v96:[add_removeRegulator]

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