Reactome | Dengue virus activates/modulates innate and adaptive immune responses

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Dengue virus activates/modulates innate and adaptive immune responses Show undefined attributes

authored	[InstanceEdit:9920565] Stephan, Ralf, 2024-09-01
created	[InstanceEdit:9920605] Stephan, Ralf, 2024-09-02
crossReference	[DatabaseIdentifier:12020825] Mondo:0005502
dbId	9920588
disease	[Disease:3244610] dengue disease
displayName	Dengue virus activates/modulates innate and adaptive immune responses
edited	[InstanceEdit:9970471] Stephan, Ralf, 2025-10-30
eventOf	[Pathway:R-HSA-9918481] Dengue Virus-Host Interactions - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:258475] symbiont-mediated perturbation of host immune response
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-9947771] Dengue virion binds CLEC5A - Homo sapiens [Reaction:R-HSA-9920638] NS1 binds C1QA - Homo sapiens [Reaction:R-HSA-9920628] NS1 binds C4A/B and C1S - Homo sapiens [Reaction:R-HSA-9920623] NS1 binds C4BP - Homo sapiens [Reaction:R-HSA-9920796] NS1 binds VTN - Homo sapiens [Reaction:R-HSA-9920793] NS4A binds MAVS - Homo sapiens [Reaction:R-HSA-9920772] prM binds IFIH1 - Homo sapiens [Reaction:R-HSA-9920882] NS2B binds CGAS - Homo sapiens [Reaction:R-HSA-9946935] DENV sfRNA binds TRIM25 - Homo sapiens [BlackBoxEvent:R-HSA-9920843] C binds TRIM25 - Homo sapiens [Reaction:R-HSA-9921319] C binds EXOC1 - Homo sapiens [Reaction:R-HSA-9921600] C binds DDX3X - Homo sapiens [Reaction:R-HSA-9920829] NS5 binds HSP90 - Homo sapiens [Reaction:R-HSA-9920878] NS5 binds STAT2 - Homo sapiens [Reaction:R-HSA-9921693] NS5 binds PML-3/4 - Homo sapiens [Reaction:R-HSA-9921721] NS5 binds RBM10 - Homo sapiens [Reaction:R-HSA-9921879] NS5 binds PAF1C - Homo sapiens [Reaction:R-HSA-3244618] DENV protease NS2B3 binds STING - Homo sapiens [BlackBoxEvent:R-HSA-3244626] DENV protease NS2B3 cleaves STING - Homo sapiens [Reaction:R-HSA-9920957] NS5 binds UBR4 - Homo sapiens [Reaction:R-HSA-9920952] NS2B3 binds IKBKE - Homo sapiens [Reaction:R-HSA-9921217] NS1 binds CLU - Homo sapiens [Reaction:R-HSA-9921544] NS1 binds MBL - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9920585] Innate and adaptive immune evasion by dengue virus [LiteratureReference:9920586] Flaviviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines [LiteratureReference:9920594] Dengue and the Lectin Pathway of the Complement System [LiteratureReference:9920589] Dengue virus and the complement alternative pathway [LiteratureReference:9920619] The Interplay between Dengue Virus and the Human Innate Immune System: A Game of Hide and Seek [LiteratureReference:9920620] How Dengue Virus Circumvents Innate Immunity [LiteratureReference:9920607] Inhibition of type I interferon induction and signalling by mosquito-borne flaviviruses [LiteratureReference:9920590] Dengue Virus Control of Type I IFN Responses: A History of Manipulation and Control
maxDepth	2
modified	[InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
name	Dengue virus activates/modulates innate and adaptive immune responses
previousReviewStatus	[ReviewStatus:9821383] three stars
relatedSpecies	[Species:3244621] Dengue virus type 2
releaseDate	2025-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9970439] Roque Ascen��o, Fernando, 2025-10-29 [InstanceEdit:9970204] Mansur, Daniel Santos, 2025-10-29
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9920588
summation	[Summation:9920611] Dengue virus nonstructural protein NS1 interacts with severa...

Referrals

(hasEvent)	[Pathway:R-HSA-9918481] Dengue Virus-Host Interactions
(hasEncapsulatedEvent)	[Pathway:R-HSA-9918487] Dengue Virus Genome Translation and Replication