Reactome | Secreted NS1 binds to HDL

Schema > BlackBoxEvent > Entries

Secreted NS1 binds to HDL Show undefined attributes

authored	[InstanceEdit:9919049] Stephan, Ralf, 2024-08-19
category	omitted
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9920038] Stephan, Ralf, 2024-08-29
crossReference	[DatabaseIdentifier:12020825] Mondo:0005502
dbId	9920071
deleted	[Deleted:9945301] Deletion of instance: 9920956
disease	[Disease:3244610] dengue disease
displayName	Secreted NS1 binds to HDL
edited	[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
eventOf	[Pathway:R-HSA-9918432] Maturation of DENV proteins - Homo sapiens
followingEvent	[Reaction:R-HSA-9921200] Secreted NS1 binds 10xCbxE-F2(44-622) - Homo sapiens [Reaction:R-HSA-9921544] NS1 binds MBL - Homo sapiens [Reaction:R-HSA-9921217] NS1 binds CLU - Homo sapiens [Reaction:R-HSA-9920796] NS1 binds VTN - Homo sapiens [Reaction:R-HSA-9920638] NS1 binds C1QA - Homo sapiens [Reaction:R-HSA-9920628] NS1 binds C4A/B and C1S - Homo sapiens [BlackBoxEvent:R-HSA-9920147] Secreted NS1 binds to other cell - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:160867] protein homooligomerization
input	8 × [Complex:R-DVI-9919961] NS1 dimer [plasma membrane] [Complex:R-HSA-265523] spherical HDL [extracellular region]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9919974] Flavivirus NS1 and Its Potential in Vaccine Development [LiteratureReference:9920563] Glycosylation mutants of dengue virus NS1 protein [LiteratureReference:9945245] Dengue virus NS1 protein conveys pro-inflammatory signals by docking onto high-density lipoproteins [LiteratureReference:9945241] Secreted dengue virus NS1 from infection is predominantly dimeric and in complex with high-density lipoprotein
maxDepth	1
modified	[InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
name	Secreted NS1 binds to HDL
output	[Complex:R-HSA-9919955] NS1:HDL [extracellular region]
precedingEvent	[Reaction:R-HSA-9920051] NS1 dimer localizes to the cell membrane - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
relatedSpecies	[Species:3244621] Dengue virus type 2
releaseDate	2025-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18 [InstanceEdit:9970439] Roque Ascen��o, Fernando, 2025-10-29
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9920071
summation	[Summation:9919976] After localizing to the cell membrane, NS1 exists as a hydro...

Referrals

(replacementInstances)	[Deleted:9945301] Deletion of instance: 9920956
(precedingEvent)	[Reaction:R-HSA-9921200] Secreted NS1 binds 10xCbxE-F2(44-622) [Reaction:R-HSA-9921544] NS1 binds MBL [Reaction:R-HSA-9921217] NS1 binds CLU [Reaction:R-HSA-9920796] NS1 binds VTN [Reaction:R-HSA-9920638] NS1 binds C1QA [Reaction:R-HSA-9920628] NS1 binds C4A/B and C1S [BlackBoxEvent:R-HSA-9920147] Secreted NS1 binds to other cell
(hasEvent)	[Pathway:R-HSA-9918432] Maturation of DENV proteins