Reactome | Proline hydroxylases hydroxylate Polyprotein

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Proline hydroxylases hydroxylate Polyprotein Show undefined attributes

authored	[InstanceEdit:9918832] Stephan, Ralf, 2024-08-18
catalystActivity	[CatalystActivity:9918835] peptidyl-proline 4-dioxygenase activity of Prolyl 4-hydroxylases [endoplasmic reticulum lumen]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9918778] Stephan, Ralf, 2024-08-18
crossReference	[DatabaseIdentifier:12020825] Mondo:0005502 [DatabaseIdentifier:9918821] RHEA:18946
dbId	9918779
disease	[Disease:3244610] dengue disease
displayName	Proline hydroxylases hydroxylate Polyprotein
edited	[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
eventOf	[Pathway:R-HSA-9918432] Maturation of DENV proteins - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9918810] HyPro-polyprotein folds - Homo sapiens
input	[SimpleEntity:R-ALL-1650779] 2OG [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-DVI-9918790] Nascent polyprotein [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-113534] O2 [endoplasmic reticulum lumen]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9918809] Cotranslational prolyl hydroxylation is essential for flavivirus biogenesis
maxDepth	1
modified	[InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
name	Proline hydroxylases hydroxylate Polyprotein
output	[SimpleEntity:R-ALL-159751] CO2 [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-1650769] SUCCA [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-DVI-9918777] unfolded HyPro-Polyprotein [endoplasmic reticulum membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9923067] Nascent polyprotein starts folding in ER - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
relatedSpecies	[Species:3244621] Dengue virus type 2
releaseDate	2025-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18 [InstanceEdit:9970439] Roque Ascen��o, Fernando, 2025-10-29
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9918779
summation	[Summation:9918815] Host collagen prolyl hydroxylases P4HA1 and P4HA2 cotranslat...

Referrals

(hasEvent)	[Pathway:R-HSA-9918432] Maturation of DENV proteins
(precedingEvent)	[BlackBoxEvent:R-HSA-9918810] HyPro-polyprotein folds

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