Reactome | NS3 melts (+)-RNA secondary structures

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NS3 melts (+)-RNA secondary structures Show undefined attributes

authored	[InstanceEdit:9922933] Stephan, Ralf, 2024-09-27
catalystActivity	[CatalystActivity:9922956] helicase activity of DENV m7G(5')pppAm-capped genomic +ssRNA:RC [endoplasmic reticulum membrane]
category	uncertain
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9922958] Stephan, Ralf, 2024-09-28
crossReference	[DatabaseIdentifier:12020825] Mondo:0005502
dbId	9922957
disease	[Disease:3244610] dengue disease
displayName	NS3 melts (+)-RNA secondary structures
edited	[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
eventOf	[Pathway:R-HSA-9918487] Dengue Virus Genome Translation and Replication - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9922965] Circularization of (+)-genomic RNA - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:590] RNA metabolic process
input	[Complex:R-DVI-9980070] DENV m7G(5')pppAm-capped genomic +ssRNA:RC [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-6806881] NTP [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9923524] Structure of the Dengue virus helicase/nucleoside triphosphatase catalytic domain at a resolution of 2.4 A [LiteratureReference:9919995] Molecular Insights into the Flavivirus Replication Complex [LiteratureReference:9925579] NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication [LiteratureReference:9945291] Thermodynamic and mechanistic analysis of the functional properties of dengue virus NS3 helicase [LiteratureReference:9920214] Structures of dengue virus RNA replicase complexes [LiteratureReference:9946475] The C-terminal 50 amino acid residues of dengue NS3 protein are important for NS3-NS5 interaction and viral replication [LiteratureReference:9946471] Dengue Virus NS4b N-Terminus Disordered Region Interacts with NS3 Helicase C-Terminal Subdomain to Enhance Helicase Activity [LiteratureReference:9946470] Recombinant dengue virus type 1 NS3 protein exhibits specific viral RNA binding and NTPase activity regulated by the NS5 protein [LiteratureReference:9954818] Identification of a Direct-Acting Antiviral Agent Targeting RNA Helicase via a Graphene Oxide Nanobiosensor [LiteratureReference:9954817] Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug
maxDepth	1
modified	[InstanceEdit:9984898] Weiser, Joel, 2026-03-12
name	NS3 melts (+)-RNA secondary structures
output	[Complex:R-DVI-9979958] DENV +ssRNA with no secondary structures:RC [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-6806885] NDP [cytosol]
precedingEvent	[Reaction:R-HSA-9922961] DENV genomic RNA binds Replication Complex - Homo sapiens [Reaction:R-HSA-9923097] NS5 acts as a cap 2'-O-methyltransferase to methylate 5? m7GpppA of DENV genomic +ssRNA - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[NegativeRegulation:9955742] Negative regulation by 'Dengue helicase inhibitor [cytosol]'
relatedSpecies	[Species:3244621] Dengue virus type 2
releaseDate	2025-12-08
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18 [InstanceEdit:9970439] Roque Ascen��o, Fernando, 2025-10-29 [InstanceEdit:9984049] Roque Ascen��o, Fernando, 2026-03-03
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9922957
summation	[Summation:9923526] The NS3 subunit of the DENV replication complex unwinds vira...
updateTrackers	[UpdateTracker:9984700] Update Tracker - [BlackBoxEvent:9922957] NS3 melts (+)-RNA secondary structures - v96:[add_removeInput, add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9984700] Update Tracker - [BlackBoxEvent:9922957] NS3 melts (+)-RNA secondary structures - v96:[add_removeInput, add_removeOutput]
(hasEvent)	[Pathway:R-HSA-9918487] Dengue Virus Genome Translation and Replication
(precedingEvent)	[BlackBoxEvent:R-HSA-9922965] Circularization of (+)-genomic RNA

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