Reactome | NS5 binds NS3

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NS5 binds NS3 Show undefined attributes

authored	[InstanceEdit:9921183] Stephan, Ralf, 2024-09-06
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9920218] Orlic-Milacic, Marija, 2024-08-29
crossReference	[DatabaseIdentifier:12020825] Mondo:0005502
dbId	9920215
disease	[Disease:3244610] dengue disease
displayName	NS5 binds NS3
edited	[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
eventOf	[Pathway:R-HSA-9918487] Dengue Virus Genome Translation and Replication - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9920087] Nonstructural proteins form the replication complex - Homo sapiens
input	[EntityWithAccessionedSequence:R-DVI-3244645] K27polyUb-NS3 [endoplasmic reticulum membrane] [EntityWithAccessionedSequence:R-DVI-9920129] NS5 [endoplasmic reticulum membrane]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9920214] Structures of dengue virus RNA replicase complexes [LiteratureReference:9921212] A small region of the dengue virus-encoded RNA-dependent RNA polymerase, NS5, confers interaction with both the nuclear transport receptor importin-beta and the viral helicase, NS3 [LiteratureReference:9946474] Establishment of a robust dengue virus NS3-NS5 binding assay for identification of protein-protein interaction inhibitors
maxDepth	1
modified	[InstanceEdit:9984898] Weiser, Joel, 2026-03-12
name	NS5 binds NS3
output	[Complex:R-DVI-9979853] NS3:NS5 [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-9918823] NS345:NS2B cleaves NS345 - Homo sapiens [BlackBoxEvent:R-HSA-9920046] NS5 is exported from nucleus - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
relatedSpecies	[Species:3244621] Dengue virus type 2
releaseDate	2025-12-08
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18 [InstanceEdit:9970439] Roque Ascen��o, Fernando, 2025-10-29 [InstanceEdit:9984049] Roque Ascen��o, Fernando, 2026-03-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9920215
summation	[Summation:9921196] DENV NS3 and NS5 interact (Takahashi et al., 2012). The poly...
updateTrackers	[UpdateTracker:9984696] Update Tracker - [Reaction:9920215] NS5 binds NS3 - v96:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9984696] Update Tracker - [Reaction:9920215] NS5 binds NS3 - v96:[add_removeOutput]
(hasEvent)	[Pathway:R-HSA-9918487] Dengue Virus Genome Translation and Replication
(precedingEvent)	[BlackBoxEvent:R-HSA-9920087] Nonstructural proteins form the replication complex