Reactome | Exosomal secretion of DENV RNA and proteins

Schema > BlackBoxEvent > Entries

Exosomal secretion of DENV RNA and proteins Show undefined attributes

authored	[InstanceEdit:9947302] Stephan, Ralf, 2025-05-04
category	uncertain
compartment	[Compartment:70101] cytosol [Compartment:383505] extracellular exosome
created	[InstanceEdit:9947356] Stephan, Ralf, 2025-05-05
crossReference	[DatabaseIdentifier:12020825] Mondo:0005502
dbId	9947387
disease	[Disease:3244610] dengue disease
displayName	Exosomal secretion of DENV RNA and proteins
edited	[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
eventOf	[Pathway:R-HSA-9918487] Dengue Virus Genome Translation and Replication - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9947465] Import of DENV RNA from exosomes - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:5083576] exosomal secretion
input	[DefinedSet:R-DVI-9947376] DENV RNA [cytosol] [EntityWithAccessionedSequence:R-HSA-5205651] MAP1LC3B [cytosol] [EntityWithAccessionedSequence:R-DVI-9959990] N-glycan myristoyl-E [plasma membrane] [EntityWithAccessionedSequence:R-DVI-9959991] N-glycan prM [plasma membrane] [Complex:R-DVI-9919961] NS1 dimer [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9947348] Dissemination of the Flavivirus Subgenomic Replicon Genome and Viral Proteins by Extracellular Vesicles [LiteratureReference:9947385] Arthropod EVs mediate dengue virus transmission through interaction with a tetraspanin domain containing glycoprotein Tsp29Fb [LiteratureReference:9947464] Dual Role of Extracellular Vesicles as Orchestrators of Emerging and Reemerging Virus Infections [LiteratureReference:9954431] Autophagy-associated dengue vesicles promote viral transmission avoiding antibody neutralization
maxDepth	1
modified	[InstanceEdit:9984898] Weiser, Joel, 2026-03-12
name	Exosomal secretion of DENV RNA and proteins
negativePrecedingEvent	[NegativePrecedingEvent:9960011] Negative relationship: NS5 synthesizes minus strand genome
output	[DefinedSet:R-DVI-9947377] DENV RNA [extracellular exosome] [EntityWithAccessionedSequence:R-HSA-9959986] MAP1LC3B [extracellular exosome] [EntityWithAccessionedSequence:R-DVI-9959988] N-glycan myristoyl-E [extracellular exosome] [EntityWithAccessionedSequence:R-DVI-9959989] N-glycan prM [extracellular exosome] [Complex:R-DVI-9980387] NS1 dimer [extracellular exosome]
precedingEvent	[Reaction:R-HSA-9923094] DENV capped genome (+)-RNA dissociates from RC - Homo sapiens [BlackBoxEvent:R-HSA-9946784] DENV mRNA is decapped - Homo sapiens [BlackBoxEvent:R-HSA-9946917] XRN1 incompletely hydrolyzes DENV decapped mRNA - Homo sapiens [BlackBoxEvent:R-HSA-9922491] Dengue virion releases its genome - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
relatedSpecies	[Species:3244621] Dengue virus type 2
releaseDate	2025-12-08
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18 [InstanceEdit:9970439] Roque Ascen��o, Fernando, 2025-10-29 [InstanceEdit:9984049] Roque Ascen��o, Fernando, 2026-03-03
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9947387
summation	[Summation:9947462] DENV genomic RNA (from DENV-2 and DENV-3 strains) and subgen...
updateTrackers	[UpdateTracker:9984691] Update Tracker - [BlackBoxEvent:9947387] Exosomal secretion of DENV RNA and proteins - v96:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9984691] Update Tracker - [BlackBoxEvent:9947387] Exosomal secretion of DENV RNA and proteins - v96:[add_removeOutput]
(hasEvent)	[Pathway:R-HSA-9918487] Dengue Virus Genome Translation and Replication
(precedingEvent)	[BlackBoxEvent:R-HSA-9947465] Import of DENV RNA from exosomes