Reactome | Nascent polyprotein starts folding in ER

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Nascent polyprotein starts folding in ER Show undefined attributes

authored	[InstanceEdit:9922958] Stephan, Ralf, 2024-09-28
category	uncertain
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9923072] Stephan, Ralf, 2024-09-29
crossReference	[DatabaseIdentifier:12020825] Mondo:0005502
dbId	9923067
disease	[Disease:3244610] dengue disease
displayName	Nascent polyprotein starts folding in ER
edited	[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
eventOf	[Pathway:R-HSA-9918487] Dengue Virus Genome Translation and Replication - Homo sapiens
followingEvent	[Reaction:R-HSA-9918779] Proline hydroxylases hydroxylate Polyprotein - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:6668] viral translation
input	[EntityWithAccessionedSequence:R-DVI-9947246] Nascent polyprotein [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9946498] Flavivirus recruits the valosin-containing protein-NPL4 complex to induce stress granule disassembly for efficient viral genome replication [LiteratureReference:9946487] The Biogenesis of Dengue Virus Replication Organelles Requires the ATPase Activity of Valosin-Containing Protein [LiteratureReference:9948210] Ribosomal stalk proteins RPLP1 and RPLP2 promote biogenesis of flaviviral and cellular multi-pass transmembrane proteins [LiteratureReference:9918809] Cotranslational prolyl hydroxylation is essential for flavivirus biogenesis [LiteratureReference:9947236] Dengue and Zika Virus 5' Untranslated Regions Harbor Internal Ribosomal Entry Site Functions [LiteratureReference:9947238] The internal ribosome entry site of the Dengue virus mRNA is active when cap-dependent translation initiation is inhibited [LiteratureReference:9947247] Dengue virus utilizes a novel strategy for translation initiation when cap-dependent translation is inhibited [LiteratureReference:9954440] Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection [LiteratureReference:9966330] Proteostasis in Viral Infection: Unfolding the Complex Virus-Chaperone Interplay
maxDepth	1
modified	[InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
name	Nascent polyprotein starts folding in ER
output	[EntityWithAccessionedSequence:R-DVI-9918790] Nascent polyprotein [endoplasmic reticulum membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9947230] Cap-dependent translation of DENV genomic RNA - Homo sapiens [BlackBoxEvent:R-HSA-9947293] IRES-mediated translation of DENV genomic RNA - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[Requirement:9925431] Requirement by 'BAG2 [cytosol]' [Requirement:9925439] Requirement by 'DNAJA2 dimer [cytosol]' [Requirement:9925435] Requirement by 'HSPA1A,B [cytosol]' [Requirement:9925429] Requirement by 'HSPA8 [cytosol]' [Requirement:9925434] Requirement by 'NAC [cytosol]' [Requirement:9946477] Requirement by 'NPLOC4:UFD1:VCP hexamer [cytosol]'
relatedSpecies	[Species:3244621] Dengue virus type 2
releaseDate	2025-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18 [InstanceEdit:9970439] Roque Ascen��o, Fernando, 2025-10-29
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9923067
summation	[Summation:9923065] Host ribosomes translate the DENV genomic RNA, producing a p...

Referrals

(hasEvent)	[Pathway:R-HSA-9918487] Dengue Virus Genome Translation and Replication
(precedingEvent)	[Reaction:R-HSA-9918779] Proline hydroxylases hydroxylate Polyprotein

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