Reactome | NS1 dimerizes and assembles into lipoprotein particles

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NS1 dimerizes and assembles into lipoprotein particles Show undefined attributes

authored	[InstanceEdit:9919049] Stephan, Ralf, 2024-08-19
category	binding
compartment	[Compartment:6791047] endoplasmic reticulum-Golgi intermediate compartment membrane
created	[InstanceEdit:9920038] Stephan, Ralf, 2024-08-29
crossReference	[DatabaseIdentifier:12020825] Mondo:0005502
dbId	9919979
disease	[Disease:3244610] dengue disease
displayName	NS1 dimerizes and assembles into lipoprotein particles
edited	[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
eventOf	[Pathway:R-HSA-9918432] Maturation of DENV proteins - Homo sapiens
followingEvent	[Reaction:R-HSA-9921527] NS1 binds COG1 - Homo sapiens [BlackBoxEvent:R-HSA-9921591] Soluble NS1 forms a hexamer (cytosol) - Homo sapiens [Reaction:R-HSA-9920051] NS1 dimer localizes to the cell membrane - Homo sapiens [BlackBoxEvent:R-HSA-9946390] NS1 dimer is ubiquitinated - Homo sapiens [BlackBoxEvent:R-HSA-9920087] Nonstructural proteins form the replication complex - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-DVI-9919005] N-glycan NS1 [endoplasmic reticulum-Golgi intermediate compartment membrane] 25 × [DefinedSet:R-ALL-9920081] NS1 lipoparticle lipid [endoplasmic reticulum-Golgi intermediate compartment membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9919950] Evidence that the mature form of the flavivirus nonstructural protein NS1 is a dimer [LiteratureReference:9920133] CryoEM structures of the multimeric secreted NS1, a major factor for dengue hemorrhagic fever [LiteratureReference:9919974] Flavivirus NS1 and Its Potential in Vaccine Development [LiteratureReference:9919993] Secreted dengue virus nonstructural protein NS1 is an atypical barrel-shaped high-density lipoprotein [LiteratureReference:9920109] The step-by-step assembly mechanism of secreted flavivirus NS1 tetramer and hexamer captured at atomic resolution
maxDepth	1
modified	[InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
name	NS1 dimerizes and assembles into lipoprotein particles NS1 forms a dimer lipoparticle
output	[Complex:R-DVI-9920022] NS1 dimer [endoplasmic reticulum-Golgi intermediate compartment membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9919011] Pre-NS1 folds and is N-glycosylated - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
relatedSpecies	[Species:3244621] Dengue virus type 2
releaseDate	2025-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18 [InstanceEdit:9970439] Roque Ascen��o, Fernando, 2025-10-29
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9919979
summation	[Summation:9920028] N-glycosylated NS1 protein forms homodimers; secreted NS1 al...

Referrals

(precedingEvent)	[Reaction:R-HSA-9921527] NS1 binds COG1 [BlackBoxEvent:R-HSA-9921591] Soluble NS1 forms a hexamer (cytosol) [Reaction:R-HSA-9920051] NS1 dimer localizes to the cell membrane [BlackBoxEvent:R-HSA-9946390] NS1 dimer is ubiquitinated [BlackBoxEvent:R-HSA-9920087] Nonstructural proteins form the replication complex
(hasEvent)	[Pathway:R-HSA-9918432] Maturation of DENV proteins