Reactome | NS5 localizes to nucleus

Schema > BlackBoxEvent > Entries

NS5 localizes to nucleus Show undefined attributes

authored	[InstanceEdit:9919049] Stephan, Ralf, 2024-08-19
category	uncertain
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9920038] Stephan, Ralf, 2024-08-29
crossReference	[DatabaseIdentifier:12020825] Mondo:0005502
dbId	9919966
disease	[Disease:3244610] dengue disease
displayName	NS5 localizes to nucleus
edited	[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
eventOf	[Pathway:R-HSA-9918432] Maturation of DENV proteins - Homo sapiens
followingEvent	[Reaction:R-HSA-9921507] NS5 interacts with Spliceosome - Homo sapiens [Reaction:R-HSA-9921264] NS5 binds TJP1 - Homo sapiens [Reaction:R-HSA-9921289] NS5 binds DAXX - Homo sapiens [Reaction:R-HSA-9921721] NS5 binds RBM10 - Homo sapiens [Reaction:R-HSA-9921693] NS5 binds PML-3/4 - Homo sapiens [Reaction:R-HSA-9921879] NS5 binds PAF1C - Homo sapiens [BlackBoxEvent:R-HSA-9920126] UBC9 SUMOylates NS5 - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:5083567] protein localization to nucleoplasm
input	[EntityWithAccessionedSequence:R-DVI-9920013] p-SGltCys-NS5 [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9920009] CRM1-mediated nuclear export of dengue virus RNA polymerase NS5 modulates interleukin-8 induction and virus production [LiteratureReference:9921212] A small region of the dengue virus-encoded RNA-dependent RNA polymerase, NS5, confers interaction with both the nuclear transport receptor importin-beta and the viral helicase, NS3 [LiteratureReference:9922936] The Transactions of NS3 and NS5 in Flaviviral RNA Replication [LiteratureReference:9924265] Ivermectin as a Broad-Spectrum Host-Directed Antiviral: The Real Deal? [LiteratureReference:9924241] The broad spectrum antiviral ivermectin targets the host nuclear transport importin ?/?1 heterodimer [LiteratureReference:9924250] Ivermectin is a specific inhibitor of importin ?/?-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus [LiteratureReference:9924254] Ivermectin Accelerates Circulating Nonstructural Protein 1 (NS1) Clearance in Adult Dengue Patients: A Combined Phase 2/3 Randomized Double-blinded Placebo Controlled Trial [LiteratureReference:9945321] Nuclear localization of dengue virus (DENV) 1-4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin
maxDepth	1
modified	[InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
name	NS5 localizes to nucleus
output	[EntityWithAccessionedSequence:R-DVI-9920104] p-SGltCys-NS5 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9919982] NS5 is glutathionylated - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[Requirement:9924239] Requirement by 'IMP?/?1 [cytosol]' [NegativeRegulation:9924261] Negative regulation by 'Importin alpha:Ivermectin [cytosol]'
regulationReference	[RegulationReference:9924240] Negative regulation by 'Importin:Ivermectin [cytosol]' Dengue virus NS1 secretion is regulated via importin-subunit ?1 controlling expression of the chaperone GRp78 and targeted by the clinical drug ivermectin
relatedSpecies	[Species:3244621] Dengue virus type 2
releaseDate	2025-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18 [InstanceEdit:9970439] Roque Ascen��o, Fernando, 2025-10-29
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9919966
summation	[Summation:9920208] Dengue virus NS5 protein is found predominantly in the nucle...

Referrals

(precedingEvent)	[Reaction:R-HSA-9921507] NS5 interacts with Spliceosome [Reaction:R-HSA-9921264] NS5 binds TJP1 [Reaction:R-HSA-9921289] NS5 binds DAXX [Reaction:R-HSA-9921721] NS5 binds RBM10 [Reaction:R-HSA-9921693] NS5 binds PML-3/4 [Reaction:R-HSA-9921879] NS5 binds PAF1C [BlackBoxEvent:R-HSA-9920126] UBC9 SUMOylates NS5
(hasEvent)	[Pathway:R-HSA-9918432] Maturation of DENV proteins

Cite Us!