Reactome | HyPro-polyprotein folds

Schema > BlackBoxEvent > Entries

HyPro-polyprotein folds Show undefined attributes

authored	[InstanceEdit:9918832] Stephan, Ralf, 2024-08-18
category	uncertain
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9918778] Stephan, Ralf, 2024-08-18
crossReference	[DatabaseIdentifier:12020825] Mondo:0005502
dbId	9918810
disease	[Disease:3244610] dengue disease
displayName	HyPro-polyprotein folds
edited	[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
eventOf	[Pathway:R-HSA-9918432] Maturation of DENV proteins - Homo sapiens
followingEvent	[Reaction:R-HSA-9918772] Dengue polyprotein cis-auto-cleaves - Homo sapiens [Reaction:R-HSA-9918817] NS2B3 cleaves polyprotein - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:384047] protein folding in endoplasmic reticulum
input	[EntityWithAccessionedSequence:R-DVI-9918777] unfolded HyPro-Polyprotein [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9918809] Cotranslational prolyl hydroxylation is essential for flavivirus biogenesis [LiteratureReference:9924260] Dengue virus NS1 secretion is regulated via importin-subunit ?1 controlling expression of the chaperone GRp78 and targeted by the clinical drug ivermectin [LiteratureReference:9954440] Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection
maxDepth	1
modified	[InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
name	HyPro-polyprotein folds
output	[EntityWithAccessionedSequence:R-DVI-9918800] folded HyPro-Polyprotein [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-9918779] Proline hydroxylases hydroxylate Polyprotein - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[Requirement:9920072] Requirement by 'HSPA5 [endoplasmic reticulum lumen]' [Requirement:9920007] Requirement by 'DNAJB11 [endoplasmic reticulum lumen]' [Requirement:9920058] Requirement by 'p-DNAJC3 [endoplasmic reticulum lumen]' [Requirement:9920103] Requirement by 'DNAJC10 [endoplasmic reticulum lumen]' [Requirement:9925433] Requirement by 'HYOU1 [endoplasmic reticulum lumen]'
regulationReference	[RegulationReference:9945585] Requirement by 'HSPA5 [endoplasmic reticulum lumen]' Dengue virus NS1 secretion is regulated via importin-subunit ?1 controlling expression of the chaperone GRp78 and targeted by the clinical drug ivermectin
relatedSpecies	[Species:3244621] Dengue virus type 2
releaseDate	2025-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18 [InstanceEdit:9970439] Roque Ascen��o, Fernando, 2025-10-29
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9918810
summation	[Summation:9919969] Folding of the Dengue virus polyprotein involves the Hsp70-d...

Referrals

(hasEvent)	[Pathway:R-HSA-9918432] Maturation of DENV proteins
(precedingEvent)	[Reaction:R-HSA-9918772] Dengue polyprotein cis-auto-cleaves [Reaction:R-HSA-9918817] NS2B3 cleaves polyprotein