Reactome | DENV genomic RNA binds Replication Complex

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DENV genomic RNA binds Replication Complex Show undefined attributes

authored	[InstanceEdit:9922933] Stephan, Ralf, 2024-09-27
category	binding
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9922958] Stephan, Ralf, 2024-09-28
crossReference	[DatabaseIdentifier:12020825] Mondo:0005502
dbId	9922961
disease	[Disease:3244610] dengue disease
displayName	DENV genomic RNA binds Replication Complex
edited	[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
eventOf	[Pathway:R-HSA-9918487] Dengue Virus Genome Translation and Replication - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9922957] NS3 melts (+)-RNA secondary structures - Homo sapiens
input	[EntityWithAccessionedSequence:R-DVI-9922609] DENV m7G(5')pppAm-capped genomic +ssRNA [cytosol] [Complex:R-DVI-9979859] Replication complex (RC) [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9919995] Molecular Insights into the Flavivirus Replication Complex [LiteratureReference:9925579] NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication
maxDepth	1
modified	[InstanceEdit:9984898] Weiser, Joel, 2026-03-12
name	DENV genomic RNA binds Replication Complex
output	[Complex:R-DVI-9980070] DENV m7G(5')pppAm-capped genomic +ssRNA:RC [endoplasmic reticulum membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9920087] Nonstructural proteins form the replication complex - Homo sapiens [BlackBoxEvent:R-HSA-9922491] Dengue virion releases its genome - Homo sapiens [BlackBoxEvent:R-HSA-9922955] NS5 synthesizes minus strand genome - Homo sapiens [Reaction:R-HSA-9923094] DENV capped genome (+)-RNA dissociates from RC - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
relatedSpecies	[Species:3244621] Dengue virus type 2
releaseDate	2025-12-08
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18 [InstanceEdit:9970439] Roque Ascen��o, Fernando, 2025-10-29 [InstanceEdit:9984049] Roque Ascen��o, Fernando, 2026-03-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9922961
summation	[Summation:9923528] Cytosolic viral RNA associates with the viral Replication Co...
updateTrackers	[UpdateTracker:9984658] Update Tracker - [Reaction:9922961] DENV genomic RNA binds Replication Complex - v96:[add_removeInput, add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9984658] Update Tracker - [Reaction:9922961] DENV genomic RNA binds Replication Complex - v96:[add_removeInput, add_removeOutput]
(hasEvent)	[Pathway:R-HSA-9918487] Dengue Virus Genome Translation and Replication
(precedingEvent)	[NegativePrecedingEvent:9960010] Futile Cycle: DENV genomic RNA binds Replication Complex [BlackBoxEvent:R-HSA-9922957] NS3 melts (+)-RNA secondary structures

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