Reactome | NS5 transfers guanylyl onto DENV genomic 5'-ppRNA

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NS5 transfers guanylyl onto DENV genomic 5'-ppRNA Show undefined attributes

authored	[InstanceEdit:9922958] Stephan, Ralf, 2024-09-28
catalystActivity	[CatalystActivity:9923063] mRNA guanylyltransferase activity of DENV pp-5'A-+ssRNA:RC [endoplasmic reticulum membrane]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9923072] Stephan, Ralf, 2024-09-29
crossReference	[DatabaseIdentifier:12020825] Mondo:0005502 [DatabaseIdentifier:9923118] RHEA:67013
dbId	9923071
disease	[Disease:3244610] dengue disease
displayName	NS5 transfers guanylyl onto DENV genomic 5'-ppRNA
edited	[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
eventOf	[Pathway:R-HSA-9918487] Dengue Virus Genome Translation and Replication - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9923104] NS5 acts as a cap N7 methyltransferase to methylate 5? G pppA of DENV genomic +ssRNA - Homo sapiens
input	[Complex:R-DVI-9980082] DENV pp-5'A-+ssRNA:RC [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-29438] GTP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9923101] The flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structure
maxDepth	1
modified	[InstanceEdit:9984898] Weiser, Joel, 2026-03-12
name	NS5 transfers guanylyl onto DENV genomic 5'-ppRNA
output	[Complex:R-DVI-9979969] DENV Gppp-5'A-+ssRNA:RC [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-HSA-9923980] NS3 cleaves triphosphate moiety of genomic +ssRNA - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
relatedSpecies	[Species:3244621] Dengue virus type 2
releaseDate	2025-12-08
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18 [InstanceEdit:9970439] Roque Ascen��o, Fernando, 2025-10-29 [InstanceEdit:9984049] Roque Ascen��o, Fernando, 2026-03-03
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9923071
summation	[Summation:9923525] The flavivirus NS5 protein, as part of the DENV Replication ...
updateTrackers	[UpdateTracker:9984654] Update Tracker - [BlackBoxEvent:9923071] NS5 transfers guanylyl onto DENV genomic 5'-ppRNA - v96:[add_removeInput, add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9984654] Update Tracker - [BlackBoxEvent:9923071] NS5 transfers guanylyl onto DENV genomic 5'-ppRNA - v96:[add_removeInput, add_removeOutput]
(hasEvent)	[Pathway:R-HSA-9918487] Dengue Virus Genome Translation and Replication
(precedingEvent)	[BlackBoxEvent:R-HSA-9923104] NS5 acts as a cap N7 methyltransferase to methylate 5? G pppA of DENV genomic +ssRNA

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