ESR binds STRN

Stable Identifier
R-HSA-9633044
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The estrogen receptor binds to the scaffolding protein striatin (STRN) in response to estrogen stimulation in endothelial cells. STRN binding promotes the membrane localization of the receptor and is required for the interaction between ESR1 and G alpha (i), as well as for downstream signaling through AKT, MAPK and eNOS (Lu et al, 2004).

Literature References
PubMed ID Title Journal Year
15569929 Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha

Lu, Q, Pallas, DC, Surks, HK, Baur, WE, Mendelsohn, ME, Karas, RH

Proc. Natl. Acad. Sci. U.S.A. 2004
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Orthologous Events
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Created