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TNKS2 [cytosol]
Stable Identifier
R-HSA-3640824
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by WNT in cancer (Homo sapiens)
XAV939 stabilizes AXIN (Homo sapiens)
XAV939 binds tankyrase to stabilize axin and inhibit WNT signaling (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
TNKS2 [cytosol] (Homo sapiens)
TNKS1/2:XAV939 [cytosol] (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
TNKS2 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP34 deubiquitinates AXIN1,AXIN2 (Homo sapiens)
RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
RibC-AXIN:TNKS [cytosol] (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
TNKS2 [cytosol] (Homo sapiens)
Ub-RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
TNKS2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN stability and activity (Homo sapiens)
TNKS and TNKS2 PARylate PTEN (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
TNKS2 [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Degradation of AXIN (Homo sapiens)
RNF146 binds RibC-AXIN:TNKS complex (Homo sapiens)
RibC-AXIN:TNKS [cytosol] (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
TNKS2 [cytosol] (Homo sapiens)
RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
RibC-AXIN:TNKS [cytosol] (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
TNKS2 [cytosol] (Homo sapiens)
RNF146 ubiquitinates ADP-ribosylated AXIN (Homo sapiens)
RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
RibC-AXIN:TNKS [cytosol] (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
TNKS2 [cytosol] (Homo sapiens)
Ub-RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
TNKS2 [cytosol] (Homo sapiens)
Tankyrase ADP-ribosylates AXIN (Homo sapiens)
AXIN:TNKS [cytosol] (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
TNKS2 [cytosol] (Homo sapiens)
RibC-AXIN:TNKS [cytosol] (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
TNKS2 [cytosol] (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
TNKS2 [cytosol] (Homo sapiens)
Tankyrase binds AXIN (Homo sapiens)
AXIN:TNKS [cytosol] (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
TNKS2 [cytosol] (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
TNKS2 [cytosol] (Homo sapiens)
Ub-RibC-AXIN is degraded by the proteasome (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
TNKS2 [cytosol] (Homo sapiens)
Ub-RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
TNKS2 [cytosol] (Homo sapiens)
USP34 deubiquitinates AXIN1,AXIN2 (Homo sapiens)
RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
RibC-AXIN:TNKS [cytosol] (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
TNKS2 [cytosol] (Homo sapiens)
Ub-RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
TNKS1/2 [cytosol] (Homo sapiens)
TNKS2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H2K2 TNKS2
Gene Names
TNKS2, PARP5B, TANK2, TNKL
Chain
chain:1-1166
Reference Genes
BioGPS Gene:80351 TNKS2
COSMIC (genes):TNKS2 TNKS2
CTD Gene:80351 TNKS2
dbSNP Gene:80351 TNKS2
ENSEMBL:ENSG00000107854 TNKS2
HGNC:15677 TNKS2
KEGG Gene (Homo sapiens):80351 TNKS2
Monarch:80351 TNKS2
NCBI Gene:80351 TNKS2
OMIM:607128 TNKS2
UCSC:Q9H2K2 TNKS2
Reference Transcript
RefSeq:NM_025235.3 TNKS2
Other Identifiers
11722461_a_at
11722462_a_at
11722463_a_at
11757893_s_at
16707379
218228_s_at
222562_s_at
222563_s_at
3257851
3257852
3257853
3257854
3257862
3257863
3257865
3257866
3257868
3257869
3257871
3257874
3257875
3257879
3257881
3257883
3257884
3257885
3257887
3257889
3257891
3257896
3257898
3257902
3257903
3257904
3257905
3257908
3257909
3257910
3257911
3257913
3257915
3257916
3257917
3257918
3257919
3257920
54706_at
54708_at
7929168
80351
A_14_P116106
A_14_P139894
A_23_P12620
GE61733
GE79043
GO:0000139
GO:0000209
GO:0000228
GO:0000242
GO:0000781
GO:0000784
GO:0003674
GO:0003950
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005635
GO:0005694
GO:0005737
GO:0005794
GO:0005815
GO:0005829
GO:0005856
GO:0006259
GO:0006464
GO:0006471
GO:0007165
GO:0007267
GO:0008150
GO:0009058
GO:0016020
GO:0016055
GO:0016740
GO:0016757
GO:0019899
GO:0032212
GO:0034641
GO:0035264
GO:0040007
GO:0040014
GO:0042592
GO:0043167
GO:0043226
GO:0046872
GO:0048471
GO:0051276
GO:0070198
GO:0070212
GO:0070213
GO:0090263
GO:1904355
GO:1904357
GO:1990404
Hs.280776.0.S2_3p_a_at
PH_hs_0014453
TC10000654.hg
g13161041_3p_a_at
g13376841_3p_a_at
Participant Of
hasMember
TNKS1/2 [cytosol]
Inferred To
Tnks [cytosol] (Drosophila melanogaster)
Tnks2 [cytosol] (Mus musculus)
Tnks2 [cytosol] (Rattus norvegicus)
ftcd [cytosol] (Xenopus tropicalis)
TNKS2 [cytosol] (Canis familiaris)
TNKS2 [cytosol] (Gallus gallus)
TNKS2 [cytosol] (Sus scrofa)
Cross References
RefSeq
NP_079511.1
ZINC - World Drugs
TNKS2_HUMAN
OpenTargets
ENSG00000107854
ZINC - FDA approved
TNKS2_HUMAN
ZINC - Substances
TNKS2_HUMAN
ZINC target
Q9H2K2
ZINC - Biogenic
TNKS2_HUMAN
PRO
Q9H2K2
PDB
4L0B
,
4J1Z
,
4UVU
,
4L10
,
4BUA
,
4BUT
,
4HLK
,
4J22
,
5FPF
,
4UVX
,
5AKW
,
6TKR
,
4UVN
,
4BUE
,
4PNR
,
3TWS
,
5FPG
,
4HLM
,
5ADS
,
4UVY
,
4UHG
,
4BU8
,
4TKG
,
4BFP
,
3TWT
,
5AL1
,
4TK0
,
4HYF
,
4TJY
,
2Y0I
,
5AL3
,
3TWW
,
5OWT
,
4J21
,
4BUS
,
5BXO
,
4L2K
,
4HKK
,
4PNQ
,
4BU3
,
4PML
,
4UI3
,
3TWX
,
3MHJ
,
4HKN
,
3UA9
,
4L31
,
4KZL
,
4BUV
,
4J3M
,
6TG4
,
4UI6
,
4W5I
,
3KR7
,
5C5Q
,
4BJ9
,
6TKP
,
4L0S
,
4BU7
,
3W51
,
4PNL
,
4UVP
,
4UFU
,
4KZQ
,
4UI7
,
5DCZ
,
6TKM
,
4L0T
,
5BXU
,
5C5P
,
4UFY
,
4BUY
,
4UVS
,
4L34
,
4HLG
,
4UVV
,
4HLH
,
3P0P
,
4BS4
,
6TKS
,
4BUU
,
4L09
,
4BUD
,
5AL5
,
3P0Q
,
5ADQ
,
6TKQ
,
5NOB
,
4UVW
,
5AKU
,
4PNS
,
4UVL
,
4UX4
,
5NSP
,
3TWR
,
5NUT
,
4TJU
,
4UVZ
,
5ADR
,
4BUF
,
4BUI
,
4PNT
,
5AL2
,
3TWU
,
4TJW
,
4HMH
,
4L2F
,
4BU9
,
4PNN
,
5OWS
,
5AL4
,
4TKI
,
4HKI
,
3TWV
,
4M7B
,
4Z68
,
4J3L
,
5AEH
,
3TWQ
,
4TK5
,
4L2G
,
5JRT
,
4UI4
,
3MHK
,
4BU5
,
4AVU
,
4BU6
,
4UI5
,
3U9H
,
4HL5
,
6TKN
,
4AVW
,
4L33
,
4PNM
,
4UVO
,
5C5R
,
4BUW
,
3KR8
,
4TKF
,
4BUX
,
4L32
,
4L0I
,
4UI8
,
4KZU
,
4BJB
,
4UVT
,
4HLF
,
4L0V
,
3U9Y
,
4BJC
,
5ADT
,
4IUE
,
3P0N
ZINC - Metabolites
TNKS2_HUMAN
HPA
ENSG00000107854-TNKS2
GeneCards
Q9H2K2
Ensembl
ENST00000371627
,
ENSP00000360689
,
ENSG00000107854
ZINC - Predictions - Purchasable
TNKS2_HUMAN
HMDB Protein
HMDBP00901
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NWV8 BABAM1
2
BABAM1 [nucleoplasm]
(R-HSA-5682582)
BABAM1 [cytosol]
(R-HSA-5691418)
0.688
5
UniProt:O43815 STRN
3
STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673902)
STRN [cytosol]
(R-HSA-9037081)
p-11Y STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673908)
0.525
2
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