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MAP4K4 [cytosol]
Stable Identifier
R-HSA-3214893
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Mitogen-activated protein kinase kinase kinase kinase 4, HGK, NIK
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Expression of MINK1/TNIK is positively regulated by ROS (Homo sapiens)
MINK1/TNIK [cytosol] (Homo sapiens)
MAP4K4 [cytosol] (Homo sapiens)
ROS oxidize thioredoxin and activate MAP3K5 (Homo sapiens)
MINK1/TNIK [cytosol] (Homo sapiens)
MAP4K4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95819 MAP4K4
Gene Names
MAP4K4, HGK, KIAA0687, NIK
Chain
initiator methionine:1, chain:2-1239
Reference Genes
BioGPS Gene:9448 MAP4K4
COSMIC (genes):MAP4K4 MAP4K4
CTD Gene:9448 MAP4K4
dbSNP Gene:9448 MAP4K4
ENSEMBL:ENSG00000071054 MAP4K4
ENSEMBL:ENSG00000071054.17 MAP4K4
HGNC:6866 MAP4K4
KEGG Gene (Homo sapiens):9448 MAP4K4
Monarch:9448 MAP4K4
NCBI Gene:9448 MAP4K4
OMIM:604666 MAP4K4
UCSC:O95819 MAP4K4
Reference Transcript
RefSeq:NM_004834.4 MAP4K4
RefSeq:NM_145687.3 MAP4K4
RefSeq:NM_001242559.1 MAP4K4
RefSeq:NM_145686.3 MAP4K4
Other Identifiers
11726070_s_at
11726071_a_at
11746470_a_at
11746471_s_at
11752067_a_at
16883568
206571_PM_s_at
206571_s_at
218181_PM_s_at
218181_s_at
222547_PM_at
222547_at
222548_PM_s_at
222548_s_at
2496742
2496743
2496744
2496745
2496747
2496774
2496791
2496793
2496796
2496800
2496802
2496804
2496805
2496806
2496807
2496811
2496812
2496819
2496822
2496825
2496826
2496828
2496834
2496835
2496836
2496837
2496842
2496844
2496846
2496847
2496849
2496850
2496852
2496855
2496857
2496859
2496860
2496863
2496865
2496866
2496867
2496868
2496869
2496870
2496871
2496872
2496873
2496874
2496875
2496876
2496877
2496878
2496880
2496882
35694_at
43478_at
54030_at
8043945
9448
A_14_P111613
A_14_P120399
A_14_P127860
A_14_P202486
A_23_P102192
A_23_P108604
A_23_P90804
GE53390
GE55470
GO:0000165
GO:0000166
GO:0001953
GO:0003824
GO:0004111
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005737
GO:0005925
GO:0006468
GO:0007155
GO:0008017
GO:0008092
GO:0012501
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0030154
GO:0030335
GO:0032014
GO:0034330
GO:0035556
GO:0036211
GO:0043066
GO:0043408
GO:0043547
GO:0046328
GO:0048812
GO:0048856
GO:0048870
GO:0051549
GO:0051894
GO:0106310
GO:0120183
GO:0140096
HMNXSV003019791
Hs.6631.0.S1_3p_a_at
ILMN_2375002
ILMN_2375003
PH_hs_0000663
TC02000617.hg
g4758523_3p_a_at
g8923351_3p_a_at
Participates
as a candidate of
MINK1/TNIK [cytosol] (Homo sapiens)
Inferred To
MAP4K4 [cytosol]
(Bos taurus)
MAP4K4 [cytosol]
(Danio rerio)
MAP4K4 [cytosol]
(Drosophila melanogaster)
MAP4K4 [cytosol]
(Mus musculus)
MAP4K4 [cytosol]
(Rattus norvegicus)
MAP4K4 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_004825.3
,
NP_001229488.1
,
NP_663720.1
,
NP_663719.2
ZINC - World Drugs
M4K4_HUMAN
Guide to Pharmacology - Targets
2088
OpenTargets
ENSG00000071054
ZINC - FDA approved
M4K4_HUMAN
ZINC - Substances
M4K4_HUMAN
ZINC - Biogenic
M4K4_HUMAN
ZINC target
O95819
PRO
O95819
PDB
5DI1
,
4U43
,
4ZP5
,
4U3Y
,
4ZK5
,
4U40
,
4U3Z
,
4OBO
,
4OBP
,
4U44
,
4U45
,
4U41
,
4RVT
,
5W5Q
,
5J95
,
4U42
,
4OBQ
ZINC - Investigational
M4K4_HUMAN
GeneCards
O95819
HPA
ENSG00000071054-MAP4K4
Ensembl
ENSG00000071054
,
ENST00000625522
,
ENSP00000343658
,
ENSP00000489579
,
ENST00000347699
,
ENST00000350878
,
ENSP00000486116
,
ENST00000634702
,
ENSP00000314363
Pharos - Targets
O95819
ZINC - Predictions - Purchasable
M4K4_HUMAN
HMDB Protein
HMDBP01495
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