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CAMK2B [cytosol]
Stable Identifier
R-HSA-9611360
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Ca/Calmodulin dependent protein kinase II beta subunit
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Assembly and cell surface presentation of NMDA receptors (Homo sapiens)
CaMKII and LRRC7 bind to NMDA receptors at postsynaptic density (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
Negative regulation of NMDA receptor-mediated neuronal transmission (Homo sapiens)
CALM1:4xCa2+ binds GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors and displaces ACTN2 (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:LRRC7:CaMKII dodecamer [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
PPM1F dephosphorylates p-T286-CaMKII (Homo sapiens)
CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling (Homo sapiens)
Ras activation upon Ca2+ influx through NMDA receptor (Homo sapiens)
Activation of RasGRF (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
NMDA-activated RASGRF1 activates RAS (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
Long-term potentiation (Homo sapiens)
CaMKII autophosphorylates (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
CaMKII binds activated NMDA receptor (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
CaMKII binds activated calmodulin (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
CaMKII phosphorylates AMPA receptor (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:p-Y-GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:p-Y-GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
Unblocking of NMDA receptors, glutamate binding and activation (Homo sapiens)
Ca2+ influx into the post-synaptic cell (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
Glycine and glutamate ligands bind GRIN1:GRIN2 NMDA receptor (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
Membrane depolarization upon activation of Ca impermeable AMPA receptors (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
Mg2+ binds GRIN1:GRIN2 NMDA receptors (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
Unblocking of GRIN1:GRIN2 NMDA receptors (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
DAG and IP3 signaling (Homo sapiens)
CaM pathway (Homo sapiens)
Calmodulin induced events (Homo sapiens)
CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
CaMKII autophosphorylates (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
CaMKII binds activated calmodulin (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
G-protein mediated events (Homo sapiens)
PLC beta mediated events (Homo sapiens)
Ca-dependent events (Homo sapiens)
CaM pathway (Homo sapiens)
Calmodulin induced events (Homo sapiens)
CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
CaMKII autophosphorylates (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
CaMKII binds activated calmodulin (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
CAMK2B [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13554 CAMK2B
Gene Names
CAMK2B, CAM2, CAMK2, CAMKB
Chain
chain:1-666
Reference Genes
BioGPS Gene:816 CAMK2B
COSMIC (genes):CAMK2B CAMK2B
CTD Gene:816 CAMK2B
dbSNP Gene:816 CAMK2B
ENSEMBL:ENSG00000058404 CAMK2B
HGNC:1461 CAMK2B
KEGG:hsa:816 CAMK2B
Monarch:816 CAMK2B
NCBI Gene:816 CAMK2B
OMIM:607707 CAMK2B
UCSC:Q13554 CAMK2B
Reference Transcript
RefSeq:NM_172080.3 CAMK2B
RefSeq:NM_172079.3 CAMK2B
RefSeq:NM_172082.3 CAMK2B
RefSeq:NM_172083.3 CAMK2B
RefSeq:NM_001220.4 CAMK2B
RefSeq:NM_001293170.2 CAMK2B
RefSeq:NM_172081.3 CAMK2B
RefSeq:NM_172084.3 CAMK2B
RefSeq:NM_172078.3 CAMK2B
Participates
as a member of
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
Other forms of this molecule
p-T287-CAMK2B [cytosol]
p-T287-CAMK2B [endocytic vesicle membrane]
p-T287-CAMK2B [nucleoplasm]
p-T287-CAMK2B [plasma membrane]
p-T287-CAMK2B [endoplasmic reticulum membrane]
Inferred To
CaMKII [cytosol]
(Drosophila melanogaster)
CAMK2B [cytosol]
(Bos taurus)
CAMK2B [cytosol]
(Canis familiaris)
CAMK2B [cytosol]
(Sus scrofa)
Camk2b [cytosol]
(Mus musculus)
Camk2b [cytosol]
(Rattus norvegicus)
unc-43 [cytosol]
(Caenorhabditis elegans)
camk2b [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_742081.1
,
NP_742078.1
,
NP_001211.3
,
NP_742076.1
,
NP_742080.1
,
NP_742075.1
,
NP_742079.1
,
NP_742077.1
,
NP_001280099.1
ZINC - World Drugs
KCC2B_HUMAN
Guide to Pharmacology - Targets
1556
OpenTargets
ENSG00000058404
ENSEMBL
ENST00000347193
,
ENSP00000351542
,
ENST00000395747
,
ENST00000440254
,
ENSP00000258682
,
ENST00000346990
,
ENSP00000326375
,
ENSP00000397937
,
ENSP00000514918
,
ENST00000258682
,
ENSG00000058404
,
ENST00000350811
,
ENST00000700285
,
ENST00000353625
,
ENST00000358707
,
ENST00000395749
,
ENSP00000326544
,
ENSP00000379098
,
ENSP00000326518
,
ENSP00000379096
,
ENSP00000326427
ZINC - FDA approved
KCC2B_HUMAN
ZINC - Substances
KCC2B_HUMAN
ZINC - Biogenic
KCC2B_HUMAN
ZINC target
Q13554
PRO
Q13554
GlyGen
Q13554
PDB
7URZ
,
7URY
,
3BHH
,
7URW
ZINC - Investigational
KCC2B_HUMAN
ZINC - Metabolites
KCC2B_HUMAN
HPA
ENSG00000058404-CAMK2B
GeneCards
CAMK2B
Pharos - Targets
Q13554
ZINC - Predictions - Purchasable
KCC2B_HUMAN
Orphanet
CAMK2B
HMDB Protein
HMDBP14189
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UI95 MAD2L2
1
MAD2L2 [nucleoplasm]
(R-HSA-59092)
0.556
3
UniProt:Q8N0Z6 TTC5
3
TTC5 [nucleoplasm]
(R-HSA-6804264)
p-S203-TTC5 [nucleoplasm]
(R-HSA-6804261)
p-S203,S221-TTC5 [nucleoplasm]
(R-HSA-6804259)
0.556
3
UniProt:O43815 STRN
5
STRN [cytosol]
(R-HSA-9037081)
STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673902)
p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673908)
STRN(1-137)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9700485)
STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9700467)
0.527
2
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