Reactome | CAMK2B [cytosol]

CAMK2B [cytosol]

Stable Identifier

R-HSA-9611360

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ca/Calmodulin dependent protein kinase II beta subunit

Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Assembly and cell surface presentation of NMDA receptors (Homo sapiens)
        
        CaMKII and LRRC7 bind to NMDA receptors at postsynaptic density (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)
      - Negative regulation of NMDA receptor-mediated neuronal transmission (Homo sapiens)
        
        CALM1:4xCa2+ binds GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors and displaces ACTN2 (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:LRRC7:CaMKII dodecamer [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)
        
        PPM1F dephosphorylates p-T286-CaMKII (Homo sapiens)
        
        CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling (Homo sapiens)
        
        Ras activation upon Ca2+ influx through NMDA receptor (Homo sapiens)
        
        Activation of RasGRF (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)
        
        NMDA-activated RASGRF1 activates RAS (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)
        
        Long-term potentiation (Homo sapiens)
        
        CaMKII autophosphorylates (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)
        
        CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)
        
        CaMKII binds activated NMDA receptor (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)
        
        CaMKII binds activated calmodulin (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)
        
        CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)
        
        CaMKII phosphorylates AMPA receptor (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)
        
        SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:p-Y-GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:p-Y-GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)
      - Unblocking of NMDA receptors, glutamate binding and activation (Homo sapiens)
        
        Ca2+ influx into the post-synaptic cell (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)
        
        Glycine and glutamate ligands bind GRIN1:GRIN2 NMDA receptor (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)
        
        Membrane depolarization upon activation of Ca impermeable AMPA receptors (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)
        
        Mg2+ binds GRIN1:GRIN2 NMDA receptors (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)
        
        Unblocking of GRIN1:GRIN2 NMDA receptors (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - DAG and IP3 signaling (Homo sapiens)
    - CaM pathway (Homo sapiens)
      - Calmodulin induced events (Homo sapiens)
        
        CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
        
        CaMKII autophosphorylates (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)
        
        CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)
        
        CaMKII binds activated calmodulin (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)
        
        CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)
- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
        
        RAS GEFs [plasma membrane] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)
        
        Ca-dependent events (Homo sapiens)
        
        CaM pathway (Homo sapiens)
        
        Calmodulin induced events (Homo sapiens)
        
        CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
        
        CaMKII autophosphorylates (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)
        
        CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)
        
        CaMKII binds activated calmodulin (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)
        
        CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2B [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13554 CAMK2B

Gene Names

CAMK2B, CAM2, CAMK2, CAMKB

Chain

chain:1-666

Reference Genes

COSMIC (genes):CAMK2B CAMK2B

dbSNP Gene:816 CAMK2B

ENSEMBL:ENSG00000058404 CAMK2B

Participates

as a member of

CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)

Other forms of this molecule

p-T287-CAMK2B [plasma membrane]

p-T287-CAMK2B [nucleoplasm]

p-T287-CAMK2B [endocytic vesicle membrane]

p-T287-CAMK2B [cytosol]

Inferred To

CAMK2B [cytosol] (Bos taurus)

CAMK2B [cytosol] (Caenorhabditis elegans)

CAMK2B [cytosol] (Canis familiaris)

CAMK2B [cytosol] (Drosophila melanogaster)

CAMK2B [cytosol] (Gallus gallus)

CAMK2B [cytosol] (Mus musculus)

CAMK2B [cytosol] (Rattus norvegicus)

CAMK2B [cytosol] (Sus scrofa)

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UI95 MAD2L2	1	MAD2L2 [nucleoplasm] (R-HSA-59092)	0.556	3
UniProt:Q8N0Z6 TTC5	3	TTC5 [nucleoplasm] (R-HSA-6804264) p-S203-TTC5 [nucleoplasm] (R-HSA-6804261) p-S203,S221-TTC5 [nucleoplasm] (R-HSA-6804259)	0.556	3
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.527	2

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