Reactome | ARHGEF5 [cytosol]

ARHGEF5 [cytosol]

Stable Identifier

R-HSA-8873909

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Rho guanine nucleotide exchange factor 5, ARHG5_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q12774 ARHGEF5

Gene Names

ARHGEF5, TIM

Chain

chain:1-1597

Reference Genes

BioGPS Gene:7984 ARHGEF5

COSMIC (genes):ARHGEF5 ARHGEF5

CTD Gene:7984 ARHGEF5

dbSNP Gene:7984 ARHGEF5

ENSEMBL:ENSG00000050327 ARHGEF5

ENSEMBL_homo_sapiens_GENE:ENSG00000050327.15 ARHGEF5

HGNC:13209 ARHGEF5

KEGG Gene (Homo sapiens):7984 ARHGEF5

Monarch:7984 ARHGEF5

NCBI Gene:7984 ARHGEF5

OMIM:600888 ARHGEF5

UCSC:Q12774 ARHGEF5

Reference Transcript

RefSeq:NM_005435.3 ARHGEF5

Other Identifiers

11736628_s_at

11755837_a_at

17052939

204765_PM_at

204765_at

3029658

3029659

3029660

3029661

3029662

3029663

3029664

3029665

3029666

3029667

3029668

3029669

3029670

3029671

3029672

3029673

3029677

3029678

3029679

3029680

3029681

3029682

3029685

3029688

3029690

3029691

3029692

3029694

3077576

3077577

3077578

3077585

3077622

3077623

3077663

3077667

3077671

3077672

3077673

3077674

3077675

3077676

3077677

3077678

3077679

3077680

3077681

3077703

3077705

35673_at

69345_at

7984

8136987

8143610

A_23_P93988

A_24_P389218

A_24_P701776

GE639053

GE79211

GO:0002102

GO:0002376

GO:0002408

GO:0005085

GO:0005515

GO:0005525

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0006351

GO:0006355

GO:0007010

GO:0008289

GO:0023052

GO:0030036

GO:0032956

GO:0035556

GO:0036211

GO:0042995

GO:0043087

GO:0043226

GO:0043507

GO:0048870

GO:0051056

GO:0051091

GO:0051493

GO:0051496

GO:0061484

GO:0065003

GO:0070161

GO:0071803

GO:0071944

GO:0098772

GO:1904591

HMNXSV003032982

HMNXSV003050531

ILMN_1657443

ILMN_1668985

ILMN_1703840

ILMN_1708093

ILMN_1729060

PH_hs_0030851

TC07000957.hg

TC07003219.hg

TC07003306.hg

U02082_at

g4885632_3p_at

Participates

as a member of

as a candidate of

Inferred To

ARHGEF5 [cytosol] (Bos taurus)

ARHGEF5 [cytosol] (Canis familiaris)

ARHGEF5 [cytosol] (Gallus gallus)

ARHGEF5 [cytosol] (Sus scrofa)

Exn [cytosol] (Drosophila melanogaster)

ephx-1 [cytosol] (Caenorhabditis elegans)

Arhgef5 [cytosol] (Mus musculus)

Arhgef5 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_005426.2

OpenTargets

ENSG00000050327

GeneCards

Q12774

HPA

ENSG00000050327-ARHGEF5

Ensembl

ENSP00000418227, ENST00000056217, ENST00000471847, ENSP00000056217, ENSG00000050327

PRO

Q12774

Pharos - Targets

Q12774

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.82	8
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.718	6
UniProt:P29353 SHC1	5	p-Y427-SHC1 [cytosol] (R-HSA-74684) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) SHC1 [cytosol] (R-HSA-74680) p-Y-SHC1 [cytosol] (R-HSA-162568)	0.597	4
UniProt:P61586 RHOA	6	RHOA [ficolin-1-rich granule membrane] (R-HSA-6804971) RHOA [secretory granule membrane] (R-HSA-6804980) RHOA [endoplasmic reticulum membrane] (R-HSA-5672082) RHOA [cytosol] (R-HSA-194866) RHOA [cell junction] (R-HSA-2134503) RHOA [plasma membrane] (R-HSA-194510)	0.564	2
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.556	3
UniProt:O15160 POLR1C	2	POLR1C [nucleoplasm] (R-HSA-63498) POLR1C [cytosol] (R-HSA-1964454)	0.556	5
UniProt:Q9NRD5 PICK1	2	PICK1 [endocytic vesicle membrane] (R-HSA-417017) PICK1 [plasma membrane] (R-HSA-416989)	0.556	3
UniProt:P46109 CRKL	2	CRKL [cytosol] (R-HSA-354384) p-CRKL [cytosol] (R-HSA-9024730)	0.547	2
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.536	4

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