Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
DOCK5 [cytosol]
Stable Identifier
R-HSA-1012991
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Dedicator of cytokinesis protein 5, DOCK5_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
DOCKs bind to RhoGEFs (Homo sapiens)
DOCK-GEFs [cytosol] (Homo sapiens)
DOCK5 [cytosol] (Homo sapiens)
DOCK-GEFs:RAC1, CDC42 [cytosol] (Homo sapiens)
DOCK-GEFs [cytosol] (Homo sapiens)
DOCK5 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GEFs activate RAC1 (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
DOCK5 [cytosol] (Homo sapiens)
RHOG GTPase cycle (Homo sapiens)
RHOG binds effectors at the plasma membrane (Homo sapiens)
RHOG plasma membrane effectors [cytosol] (Homo sapiens)
DOCK5 [cytosol] (Homo sapiens)
RHOG:GTP:RHOG plasma membrane effectors [plasma membrane] (Homo sapiens)
RHOG plasma membrane effectors [cytosol] (Homo sapiens)
DOCK5 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H7D0 DOCK5
Gene Names
DOCK5
Chain
chain:1-1870
Reference Genes
BioGPS Gene:80005 DOCK5
COSMIC (genes):DOCK5 DOCK5
CTD Gene:80005 DOCK5
dbSNP Gene:80005 DOCK5
ENSEMBL:ENSG00000147459 DOCK5
HGNC:23476 DOCK5
Monarch:80005 DOCK5
NCBI Gene:80005 DOCK5
OMIM:616904 DOCK5
UCSC:Q9H7D0 DOCK5
Reference Transcript
RefSeq:NM_024940.7 DOCK5
Other Identifiers
11736564_at
11759205_a_at
11762025_a_at
1569590_PM_at
1569590_at
1570078_PM_a_at
1570078_a_at
17067031
219921_PM_s_at
219921_s_at
230263_PM_s_at
230263_s_at
3090523
3090524
3090525
3090526
3090537
3090548
3090550
3090554
3090556
3090563
3090565
3090566
3090567
3090568
3090570
3090571
3090572
3090575
3090578
3090579
3090581
3090583
3090584
3090585
3090586
3090589
3090590
3090591
3090593
3090594
3090600
3090602
3090603
3090604
3090606
3090610
3090617
3090618
3090619
3090620
3090621
3090622
3090623
3090624
3090626
3090627
3090628
3090630
3090631
3090634
3090637
3090641
3090642
3090646
3090647
3090649
3090651
3090653
3090654
3090655
3090656
3090658
3090659
3090660
3090661
3090662
3090663
3090665
3090666
3090667
3090668
3090669
3090670
3090671
3090672
3090673
3090674
3090675
3090676
3090677
3090678
3090679
3090680
61126_at
80005
8145365
A_23_P60089
A_24_P350245
A_33_P3259775
GE83011
GO:0002102
GO:0003013
GO:0005085
GO:0005096
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0007264
GO:0007520
GO:0010634
GO:0016477
GO:0016601
GO:0031267
GO:0042995
GO:0043226
GO:0046849
GO:0048870
GO:0065003
GO:0070161
GO:0071800
GO:0098772
GO:1900026
GO:1904694
GO:1904754
HMNXSV003042339
HMNXSV003043084
HMNXSV003052232
Hs.131705.0.A1_3p_at
Hs2.376960.2.S1_3p_a_at
Hs2.383002.1.S1_3p_at
ILMN_1752455
PH_hs_0014532
TC08001844.hg
TC08002590.hg
g13376416_3p_at
p26477
Participates
as a candidate of
RAC1 GEFs [cytosol] (Homo sapiens)
RHOG plasma membrane effectors [cytosol] (Homo sapiens)
DOCK-GEFs [cytosol] (Homo sapiens)
Inferred To
docA [cytosol]
(Dictyostelium discoideum)
docB [cytosol]
(Dictyostelium discoideum)
docD [cytosol]
(Dictyostelium discoideum)
Dock5 [cytosol]
(Mus musculus)
Dock5 [cytosol]
(Rattus norvegicus)
Homologues of DOCK5 [cytosol]
(Dictyostelium discoideum)
docC [cytosol]
(Dictyostelium discoideum)
ced-5 [cytosol]
(Caenorhabditis elegans)
dock5 [cytosol]
(Danio rerio)
dock5 [cytosol]
(Xenopus tropicalis)
DCK1 [cytosol]
(Saccharomyces cerevisiae)
DOCK5 [cytosol]
(Bos taurus)
DOCK5 [cytosol]
(Canis familiaris)
DOCK5 [cytosol]
(Gallus gallus)
DOCK5 [cytosol]
(Sus scrofa)
mbc [cytosol]
(Drosophila melanogaster)
Cross References
ENSEMBL
ENSP00000429737
,
ENST00000481100
,
ENST00000276440
,
ENSP00000276440
OpenTargets
ENSG00000147459
HPA
ENSG00000147459-DOCK5
PRO
Q9H7D0
Pharos - Targets
Q9H7D0
GlyGen
Q9H7D0
HMDB Protein
HMDBP08356
PDB
8JHK
,
7DPA
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.688
4
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.643
4
UniProt:P46109 CRKL
2
CRKL [cytosol]
(R-HSA-354384)
p-CRKL [cytosol]
(R-HSA-9024730)
0.527
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text