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AREL1 [cytosol]
Stable Identifier
R-HSA-8851648
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Apoptosis-resistant E3 ubiquitin protein ligase 1 ecNumber6.3.2.-/ecNumber, AREL1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
AREL1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
AREL1 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
AREL1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
AREL1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
AREL1 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
AREL1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
AREL1 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
AREL1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
AREL1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
AREL1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15033 AREL1
Gene Names
AREL1, KIAA0317
Chain
chain:1-823
Reference Genes
BioGPS Gene:9870 AREL1
COSMIC (genes):AREL1 AREL1
CTD Gene:9870 AREL1
dbSNP Gene:9870 AREL1
ENSEMBL:ENSG00000119682.18 AREL1
HGNC:20363 AREL1
KEGG Gene (Homo sapiens):9870 AREL1
Monarch:9870 AREL1
NCBI Gene:9870 AREL1
OMIM:615380 AREL1
UCSC:O15033 AREL1
Reference Transcript
RefSeq:XM_011537415.2 AREL1
RefSeq:NM_001039479.1 AREL1
Other Identifiers
0002190451
11716990_at
11716991_at
11752176_s_at
16794767
202128_PM_at
202128_at
32801_at
3572047
3572048
3572049
3572050
3572051
3572052
3572053
3572054
3572055
3572058
3572059
3572060
3572061
3572063
3572065
3572069
3572070
3572071
3572072
3572074
3572075
3572076
3572077
3572078
3572080
3572081
3572082
3572084
3572092
7980189
9870
AB002315_at
A_23_P369987
GE79973
GO:0000209
GO:0004842
GO:0005515
GO:0005622
GO:0005737
GO:0005829
GO:0006511
GO:0006915
GO:0006954
GO:0012501
GO:0016567
GO:0016740
GO:0030163
GO:0036211
GO:0043066
GO:0043161
GO:0050727
GO:0061630
GO:0070979
GO:0140096
GO:1990390
HMNXSV003004265
HMNXSV003049607
PH_hs_0025334
PH_hs_0040164
TC14001310.hg
g7662051_3p_at
Participates
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
Dmel\CG4238 [cytosol]
(Drosophila melanogaster)
AREL1 [cytosol]
(Bos taurus)
AREL1 [cytosol]
(Canis familiaris)
AREL1 [cytosol]
(Dictyostelium discoideum)
AREL1 [cytosol]
(Gallus gallus)
AREL1 [cytosol]
(Plasmodium falciparum)
AREL1 [cytosol]
(Sus scrofa)
ptr1 [cytosol]
(Schizosaccharomyces pombe)
Arel1 [cytosol]
(Mus musculus)
Arel1 [cytosol]
(Rattus norvegicus)
TOM1 [cytosol]
(Saccharomyces cerevisiae)
arel1 [cytosol]
(Danio rerio)
arel1 [cytosol]
(Xenopus tropicalis)
Homologues of AREL1 [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_001034568.1
,
XP_011535717.1
OpenTargets
ENSG00000119682
GeneCards
O15033
HPA
ENSG00000119682-AREL1
Ensembl
ENST00000356357
,
ENST00000681599
,
ENSP00000348714
,
ENSG00000119682
,
ENSP00000505623
PRO
O15033
Pharos - Targets
O15033
PDB
6JX5
,
6LOH
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P46109 CRKL
2
CRKL [cytosol]
(R-HSA-354384)
p-CRKL [cytosol]
(R-HSA-9024730)
0.488
2
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