Reactome | EDC4 [cytosol]

EDC4 [cytosol]

Stable Identifier

R-HSA-429963

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Enhancer of mRNA-decapping protein 4, EDC4_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q6P2E9 EDC4

Gene Names

EDC4, HEDLS

Chain

initiator methionine:, chain:2-1401

Reference Genes

BioGPS Gene:23644 EDC4

COSMIC (genes):EDC4 EDC4

CTD Gene:23644 EDC4

dbSNP Gene:23644 EDC4

ENSEMBL:ENSG00000038358 EDC4

HGNC:17157 EDC4

KEGG:hsa:23644 EDC4

Monarch:23644 EDC4

NCBI Gene:23644 EDC4

OMIM:606030 EDC4

UCSC:Q6P2E9 EDC4

Reference Transcript

RefSeq:NM_014329.4 EDC4

Other Identifiers

11717179_a_at

11748584_a_at

11761312_x_at

16820296

16820331

202496_PM_at

202496_at

23644

3665883

3665884

3665885

3665887

3665888

3665889

3665891

3665892

3665893

3665894

3665895

3665896

3665897

3665898

3665899

3665900

3665901

3665902

3665903

3665906

3665907

3665908

3665909

3665910

3665911

3665912

3665913

3665914

3665915

3665916

3665917

3665918

3665919

3665920

3665921

3665922

3665923

3665924

3665925

3665926

3665927

3665928

3665929

3665930

3665931

3665932

3665933

3665934

3665937

3665938

3665939

3665940

3665941

3665948

36670_at

7996685

A_14_P134021

A_24_P399009

A_33_P3294392

GE57701

GO:0000932

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0008150

GO:0016020

GO:0016071

GO:0031087

GO:0036464

GO:0043226

HMNXSV003045979

ILMN_1665212

L26339_at

PH_hs_0004362

TC16001609.hg

TC16002080.hg

g7657509_3p_at

Participates

as a component of

DCP1-DCP2 Decapping Complex [cytosol] (Homo sapiens)

Inferred To

Edc4 [cytosol] (Mus musculus)

Edc4 [cytosol] (Rattus norvegicus)

EDC4 [cytosol] (Bos taurus)

EDC4 [cytosol] (Canis familiaris)

EDC4 [cytosol] (Dictyostelium discoideum)

EDC4 [cytosol] (Gallus gallus)

EDC4 [cytosol] (Plasmodium falciparum)

EDC4 [cytosol] (Sus scrofa)

Ge-1 [cytosol] (Drosophila melanogaster)

edc4 [cytosol] (Danio rerio)

edc4 [cytosol] (Xenopus tropicalis)

Ghost homologue of EDC4 [cytosol] (Saccharomyces cerevisiae)

edc-4 [cytosol] (Caenorhabditis elegans)

Cross References

ENSEMBL

ENSP00000351811, ENSG00000038358, ENST00000358933

OpenTargets

ENSG00000038358

GeneCards

EDC4

HPA

ENSG00000038358-EDC4

PRO

Q6P2E9

Pharos - Targets

Q6P2E9

GlyGen

Q6P2E9

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NPI6 DCP1A	1	DCP1A [cytosol] (R-HSA-430043)	0.88	12
UniProt:Q8IU60 DCP2	1	DCP2 [cytosol] (R-HSA-429937)	0.86	11
UniProt:Q8IZH2 XRN1	1	XRN1 [cytosol] (R-HSA-429835)	0.748	5
UniProt:Q96ES7 SGF29	1	SGF29 [nucleoplasm] (R-HSA-3662279)	0.725	6
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.643	4
UniProt:Q86XL3 ANKLE2	2	Ac-K302-ANKLE2 [endoplasmic reticulum membrane] (R-HSA-9667946) ANKLE2 [endoplasmic reticulum membrane] (R-HSA-2529000)	0.564	2
UniProt:P46109 CRKL	2	CRKL [cytosol] (R-HSA-354384) p-CRKL [cytosol] (R-HSA-9024730)	0.527	2
UniProt:P19525 EIF2AK2	5	EIF2AK2 [cytosol] (R-HSA-168699) p-EIF2AK2 [cytosol] (R-HSA-9833834) ISG15-EIF2AK2 [cytosol] (R-HSA-9833968) SUMO-EIF2AK2 [cytosol] (R-HSA-9834829) p-EIF2AK2 [nucleoplasm] (R-HSA-9836332)	0.499	2

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