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PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN [cytosol]
Stable Identifier
R-HSA-8948841
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN stability and activity (Homo sapiens)
Proteasome degrades polyubiquitinated PTEN (Homo sapiens)
PolyUb-PTEN, K48polyUb-K289-PTEN, PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN [cytosol] (Homo sapiens)
PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN [cytosol] (Homo sapiens)
RNF146 polyubiquitinates PARylated PTEN (Homo sapiens)
PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P60484 PTEN
Gene Names
PTEN, MMAC1, TEP1
Chain
initiator methionine:, chain:2-403
Reference Genes
COSMIC (genes):PTEN PTEN
COSMIC (genes):TEP1 PTEN
dbSNP Gene:5728 PTEN
ENSEMBL:ENSG00000171862 PTEN
Participates
as a member of
PolyUb-PTEN, K48polyUb-K289-PTEN, PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN [cytosol] (Homo sapiens)
as an output of
RNF146 polyubiquitinates PARylated PTEN (Homo sapiens)
Other forms of this molecule
K48polyUb-PTEN [cytosol]
PolyUb-PTEN [nucleoplasm]
PTEN H93R [cytosol]
PTEN C124R [cytosol]
PTEN H93Y [cytosol]
PTEN R130G [cytosol]
PTEN H93D [cytosol]
PTEN R130L [cytosol]
PTEN H93A [cytosol]
PTEN G129E [cytosol]
PTEN S170N [cytosol]
PTEN R173P [cytosol]
PTEN R130Q [cytosol]
PTEN H93Q [cytosol]
PTEN G129R [cytosol]
PTEN H123Y [cytosol]
PTEN S170R [cytosol]
PTEN R173C [cytosol]
PTEN R173H [cytosol]
PTEN C124S [cytosol]
PTEN C124Y [cytosol]
PTEN R130P [cytosol]
PTEN C124F [cytosol]
PTEN G129V [cytosol]
PTEN S170I [cytosol]
PTEN S170G [cytosol]
PTEN E99* [cytosol]
PTEN G165* [cytosol]
PTEN E157* [cytosol]
PTEN E150* [cytosol]
PTEN E43* [cytosol]
PTEN Q17* [cytosol]
PTEN E91* [cytosol]
PTEN S59* [cytosol]
PTEN E114* [cytosol]
PTEN L139* [cytosol]
PTEN Y176* [cytosol]
PTEN Y177* [cytosol]
PTEN Q149* [cytosol]
PTEN L146* [cytosol]
PTEN G20* [cytosol]
PTEN G127* [cytosol]
PTEN Y46* [cytosol]
PTEN L182* [cytosol]
PTEN Q97* [cytosol]
PTEN Q171* [cytosol]
PTEN G129* [cytosol]
PTEN E18* [cytosol]
PTEN Y180* [cytosol]
PTEN K163* [cytosol]
PTEN Y27* [cytosol]
PTEN Y65* [cytosol]
PTEN Y68* [cytosol]
PTEN K128* [cytosol]
PTEN Y138* [cytosol]
PTEN K125* [cytosol]
PTEN Y88* [cytosol]
PTEN Q110* [cytosol]
PTEN L23* [cytosol]
PTEN E7* [cytosol]
PTEN C105* [cytosol]
PTEN E73* [cytosol]
PTEN K62* [cytosol]
PTEN E40* [cytosol]
PTEN Y178* [cytosol]
PTEN R130* [cytosol]
PTEN W111* [cytosol]
PTEN R11* [cytosol]
PTEN K13* [cytosol]
PTEN Y174* [cytosol]
PTEN K147* [cytosol]
PTEN R84* [cytosol]
PTEN G293* [cytosol]
PTEN S287* [cytosol]
PTEN Q214* [cytosol]
PTEN S229* [cytosol]
PTEN Q219* [cytosol]
PTEN Q261* [cytosol]
PTEN E299* [cytosol]
PTEN Y336* [cytosol]
PTEN Q245* [cytosol]
PTEN Y225* [cytosol]
PTEN Y240* [cytosol]
PTEN C218* [cytosol]
PTEN C250* [cytosol]
PTEN L247* [cytosol]
PTEN G209* [cytosol]
PTEN C211* [cytosol]
PTEN G230* [cytosol]
PTEN Q298* [cytosol]
PTEN L320* [cytosol]
PTEN E242* [cytosol]
PTEN K332* [cytosol]
PTEN E284* [cytosol]
PTEN E291* [cytosol]
PTEN K330* [cytosol]
PTEN E314* [cytosol]
PTEN Y346* [cytosol]
PTEN C296* [cytosol]
PTEN W274* [cytosol]
PTEN R233* [cytosol]
PTEN R335* [cytosol]
PTEN [cytosol]
PTEN [nucleoplasm]
MonoUb-K13,K289-PTEN [nucleoplasm]
MonoUb-K13,K289-PTEN [cytosol]
K48polyUb-K289-PTEN [cytosol]
PolyUb-PTEN [cytosol]
K27polyUb-PTEN [cytosol]
p-3S,2T-PTEN [cytosol]
RibC-E40,E150,D326-PTEN [cytosol]
p-Y336-PTEN [cytosol]
PTEN K344* [cytosol]
PTEN K221* [cytosol]
PTEN E288* [cytosol]
PTEN E235* [cytosol]
PTEN K263* [cytosol]
PTEN E307* [cytosol]
PTEN R189* [cytosol]
PTEN E256* [cytosol]
Inferred To
phospho-pteN [cytosol]
(Dictyostelium discoideum)
phospho-PTEN [cytosol]
(Bos taurus)
phospho-PTEN [cytosol]
(Canis familiaris)
phospho-PTEN [cytosol]
(Sus scrofa)
phospho-TEP1 [cytosol]
(Saccharomyces cerevisiae)
phospho-daf-18 [cytosol]
(Caenorhabditis elegans)
phospho-pten [cytosol]
(Xenopus tropicalis)
Homologues of PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN [cytosol]
(Dictyostelium discoideum)
phospho-PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN [cytosol]
(Dictyostelium discoideum)
phospho-PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN [cytosol]
(Gallus gallus)
phospho-cnrN [cytosol]
(Dictyostelium discoideum)
phospho-ptn1 [cytosol]
(Schizosaccharomyces pombe)
phospho-Pten [cytosol]
(Drosophila melanogaster)
phospho-Pten [cytosol]
(Mus musculus)
phospho-Pten [cytosol]
(Rattus norvegicus)
phospho-ptenb [cytosol]
(Danio rerio)
Modified Residues
Name
adenosine diphosphoribosyl (ADP-ribosyl) modified residue at 40
Coordinate
40
PsiMod Name
adenosine diphosphoribosyl (ADP-ribosyl) modified residue
PsiMod Definition
A protein modification that effectively results from forming an adduct with ADP-ribose through formation of a glycosidic bond.
Name
adenosine diphosphoribosyl (ADP-ribosyl) modified residue at 150
Coordinate
150
PsiMod Name
adenosine diphosphoribosyl (ADP-ribosyl) modified residue
PsiMod Definition
A protein modification that effectively results from forming an adduct with ADP-ribose through formation of a glycosidic bond.
Name
adenosine diphosphoribosyl (ADP-ribosyl) modified residue at 326
Coordinate
326
PsiMod Name
adenosine diphosphoribosyl (ADP-ribosyl) modified residue
PsiMod Definition
A protein modification that effectively results from forming an adduct with ADP-ribose through formation of a glycosidic bond.
Name
ubiquitinylated lysine (polyubiquitin chain [cytosol]) at 342
Coordinate
342
Modification
polyubiquitin chain [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (polyubiquitin chain [cytosol]) at 344
Coordinate
344
Modification
polyubiquitin chain [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (polyubiquitin chain [cytosol]) at 349
Coordinate
349
Modification
polyubiquitin chain [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Interactors (26)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O14745 NHRF1
0.771
7
UniProt:P09619 PDGFRB
3
p-12Y-PDGFRB [plasma membrane]
(R-HSA-186803)
PDGFRB [plasma membrane]
(R-HSA-186767)
p-11Y-PDGFRB [plasma membrane]
(R-HSA-8864039)
0.675
3
UniProt:Q15599 NHRF2
0.639
5
UniProt:P42685 FRK
4
p-Y387-FRK [cytosol]
(R-HSA-8847965)
FRK [specific granule lumen]
(R-HSA-6801037)
FRK [extracellular region]
(R-HSA-6806235)
FRK [azurophil granule lumen]
(R-HSA-6799142)
0.639
7
UniProt:Q5TCQ9 MAGI3
0.633
6
UniProt:Q06830 PRDX1
3
PRDX1 [cytosol]
(R-HSA-3341270)
HOOS-C52-PRDX1 [cytosol]
(R-HSA-5629198)
p-T90-PRDX1 [cytosol]
(R-HSA-8868564)
0.632
7
UniProt:P30260 CDC27
2
CDC27 [nucleoplasm]
(R-HSA-174175)
CDC27 [cytosol]
(R-HSA-174073)
0.616
7
UniProt:P60484 PTEN
20
K48polyUb-PTEN [cytosol]
(R-HSA-8874327)
PolyUb-PTEN [nucleoplasm]
(R-HSA-6782515)
PTEN H93R [cytosol]
(R-HSA-2318524)
PTEN C124R [cytosol]
(R-HSA-2317439)
PTEN H93Y [cytosol]
(R-HSA-2318520)
PTEN R130G [cytosol]
(R-HSA-2317339)
PTEN H93D [cytosol]
(R-HSA-2318550)
PTEN R130L [cytosol]
(R-HSA-2317430)
PTEN H93A [cytosol]
(R-HSA-2318544)
PTEN G129E [cytosol]
(R-HSA-2318509)
PTEN S170N [cytosol]
(R-HSA-2318408)
PTEN R173P [cytosol]
(R-HSA-2317480)
PTEN R130Q [cytosol]
(R-HSA-2317416)
PTEN H93Q [cytosol]
(R-HSA-2318565)
PTEN G129R [cytosol]
(R-HSA-2318501)
PTEN H123Y [cytosol]
(R-HSA-2318469)
PTEN S170R [cytosol]
(R-HSA-2318437)
PTEN R173C [cytosol]
(R-HSA-2317478)
PTEN R173H [cytosol]
(R-HSA-2317473)
PTEN C124S [cytosol]
(R-HSA-2317379)
0.615
9
UniProt:O43791 SPOP
1
SPOP [nucleoplasm]
(R-HSA-5635035)
0.611
4
UniProt:P35226 BMI1
3
BMI1 [nucleoplasm]
(R-HSA-389121)
p-S-BMI1 [nucleoplasm]
(R-HSA-3229116)
monoSUMO1-K88-BMI1 [nucleoplasm]
(R-HSA-4551729)
0.61
7
UniProt:Q9R1L5 MAST1
0.593
3
UniProt:O60307 MAST3
0.593
3
UniProt:Q60592 MAST2
0.593
4
UniProt:P46934 NEDD4
1
NEDD4 [cytosol]
(R-HSA-975992)
0.591
4
UniProt:O88382 MAGI2
0.581
3
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.524
2
UniProt:Q9JHL1 NHRF2
0.524
2
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.508
2
UniProt:Q9JK71 MAGI3
0.508
3
UniProt:Q9P0U4 CXXC1
1
CXXC1 [nucleoplasm]
(R-HSA-535610)
0.508
2
UniProt:Q03135 CAV1
5
CAV1 [Golgi membrane]
(R-HSA-204504)
CAV1 [plasma membrane]
(R-HSA-534994)
CAV1 [lipid droplet]
(R-HSA-163510)
CAV1 [endocytic vesicle membrane]
(R-HSA-535009)
CAV1 [early endosome membrane]
(R-HSA-5368451)
0.499
2
UniProt:Q9ULX6 AKAP8L
1
AKAP8L [nucleoplasm]
(R-HSA-9821364)
0.499
2
UniProt:Q16643 DBN1
1
DBN1 [cytosol]
(R-HSA-9714666)
0.471
5
UniProt:Q9UJX3 ANAPC7
2
ANAPC7 [nucleoplasm]
(R-HSA-174204)
ANAPC7 [cytosol]
(R-HSA-174242)
0.462
2
UniProt:Q9UJX5 ANAPC4
2
ANAPC4 [cytosol]
(R-HSA-174168)
ANAPC4 [nucleoplasm]
(R-HSA-174115)
0.462
2
UniProt:Q9UJX4 ANAPC5
2
ANAPC5 [cytosol]
(R-HSA-174211)
ANAPC5 [nucleoplasm]
(R-HSA-174153)
0.462
2
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