PTEN missense mutation that results in the substitution of glycine at position 129 with valine affects the conserved H-C-K/R-A-G-K-G-R sequence (corresponding to HCXXGXXR motif of protein tyrosine phosphatases) in the catalytic cleft of the PTEN phosphatase domain. PTEN G129V (Gly129Val) mutant has not been studied directly but is assumed to have impaired phosphoinositide phosphatase activity, similar to other G129 substitution mutants of PTEN (Han et al. 2000).
Kato, H, Shibata, H, Matsuno, S, Shiiba, K, Han, SY, Kato, S, Ishioka, C, Ishii, S, Kanamaru, R, Suzuki, T
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![PTEN G129V [cytosol] icon](/icon/R-ICO-013990.svg){kind=icon}
