Reactome | DLG2 [cytosol]

DLG2 [cytosol]

Stable Identifier

R-HSA-6794230

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PSD-93, Disks large homolog 2, DLG2_HUMAN, chapsyn-110

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Protein-protein interactions at synapses (Homo sapiens)
  - Neurexins and neuroligins (Homo sapiens)
    - ABP1 binds SHANK proteins (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3:DBNL [cytosol] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
    - BEGAIN binds DLG2,DLG3,DLG4 (Homo sapiens)
      - NMDA receptor complex:DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
      - NMDA receptor complex:PSD-95:BEGAIN [plasma membrane] (Homo sapiens)
        
        NMDA receptor complex:DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
    - GKAPs bind PSD-95 members (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
      - NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
    - HOMER binds SHANK proteins (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3:2xHOMER1,2,3:GRM1,5 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
    - NLGNs binds PSD-95 subfamily members (Homo sapiens)
      - DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
      - NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
    - NMDA receptor complex:DLG2,DLG3,DLG4 binds SPAR (Homo sapiens)
      - NMDA receptor complex:DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
      - NMDA receptor complex:DLG2,DLG3,DLG4:SPAR [plasma membrane] (Homo sapiens)
        
        NMDA receptor complex:DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
    - NMDA receptor complex:DLG2,DLG3,DLG4:SPAR binds PDLIM5 (Homo sapiens)
      - NMDA receptor complex:DLG2,DLG3,DLG4:SPAR [plasma membrane] (Homo sapiens)
        
        NMDA receptor complex:DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
      - NMDA receptor complex:DLG2,DLG3,DLG4:SPAR:PDLIM5 [plasma membrane] (Homo sapiens)
        
        NMDA receptor complex:DLG2,DLG3,DLG4:SPAR [plasma membrane] (Homo sapiens)
        
        NMDA receptor complex:DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
    - NMDAR binds PSD-95 subfamily members (Homo sapiens)
      - DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
      - NMDA receptor complex:DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
    - SHANK proteins bind GKAPs (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15700 DLG2

Gene Names

DLG2

Chain

chain:1-870

Reference Genes

BioGPS Gene:1740 DLG2

COSMIC (genes):DLG2 DLG2

CTD Gene:1740 DLG2

dbSNP Gene:1740 DLG2

ENSEMBL:ENSG00000150672 DLG2

HGNC:2901 DLG2

KEGG:hsa:1740 DLG2

Monarch:1740 DLG2

NCBI Gene:1740 DLG2

OMIM:603583 DLG2

UCSC:Q15700 DLG2

Reference Transcript

Participates

as a member of

DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)

Other forms of this molecule

DLG2 [plasma membrane]

Inferred To

dlg-1 [cytosol] (Caenorhabditis elegans)

dlg2 [cytosol] (Danio rerio)

DLG2 [cytosol] (Canis familiaris)

Dlg2 [cytosol] (Mus musculus)

Dlg2 [cytosol] (Rattus norvegicus)

dlg1 [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_001355.2, NP_001193698.1, NP_001136171.1, NP_001136172.1, NP_001136174.1

OpenTargets

ENSG00000150672

ENSEMBL

ENSP00000365272, ENST00000376104, ENST00000426717, ENST00000418306, ENSP00000393049, ENST00000280241, ENSP00000280241, ENSP00000381355, ENSG00000150672, ENST00000398309, ENSP00000402275

HPA

ENSG00000150672-DLG2

GeneCards

DLG2

PRO

Q15700

Pharos - Targets

Q15700

GlyGen

Q15700

PDB

2HE2, 2BYG

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62241 RPS8	2	RPS8 [cytosol] (R-HSA-72385) RPS8 [nucleoplasm] (R-HSA-6791203)	0.556	3
UniProt:Q7L5A8 FA2H	1	FA2H [endoplasmic reticulum membrane] (R-HSA-5693771)	0.556	3
UniProt:Q9UIV8 SERPINB13	1	SERPINB13 [lysosomal lumen] (R-HSA-8938045)	0.556	3
UniProt:P04004 VTN	1	VTN [extracellular region] (R-HSA-215971)	0.556	3
UniProt:Q8WUA2 PPIL4	1	PPIL4 [nucleoplasm] (R-HSA-8952113)	0.556	3
UniProt:O60469 DSCAM	1	DSCAM [plasma membrane] (R-HSA-197881)	0.488	3