Reactome | DLG2 [cytosol]

DLG2 [cytosol]

Stable Identifier

R-HSA-6794230

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PSD-93, Disks large homolog 2, DLG2_HUMAN, chapsyn-110

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Protein-protein interactions at synapses (Homo sapiens)
  - Neurexins and neuroligins (Homo sapiens)
    - ABP1 binds SHANK proteins (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3:DBNL [cytosol] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
    - BEGAIN binds DLG2,DLG3,DLG4 (Homo sapiens)
      - NMDA receptor complex:DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
      - NMDA receptor complex:PSD-95:BEGAIN [plasma membrane] (Homo sapiens)
        
        NMDA receptor complex:DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
    - GKAPs bind PSD-95 members (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
      - NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
    - HOMER binds SHANK proteins (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3:2xHOMER1,2,3:GRM1,5 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
    - NLGNs binds PSD-95 subfamily members (Homo sapiens)
      - DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
      - NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
    - NMDA receptor complex:DLG2,DLG3,DLG4 binds SPAR (Homo sapiens)
      - NMDA receptor complex:DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
      - NMDA receptor complex:DLG2,DLG3,DLG4:SPAR [plasma membrane] (Homo sapiens)
        
        NMDA receptor complex:DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
    - NMDA receptor complex:DLG2,DLG3,DLG4:SPAR binds PDLIM5 (Homo sapiens)
      - NMDA receptor complex:DLG2,DLG3,DLG4:SPAR [plasma membrane] (Homo sapiens)
        
        NMDA receptor complex:DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
      - NMDA receptor complex:DLG2,DLG3,DLG4:SPAR:PDLIM5 [plasma membrane] (Homo sapiens)
        
        NMDA receptor complex:DLG2,DLG3,DLG4:SPAR [plasma membrane] (Homo sapiens)
        
        NMDA receptor complex:DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
    - NMDAR binds PSD-95 subfamily members (Homo sapiens)
      - DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
      - NMDA receptor complex:DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
    - SHANK proteins bind GKAPs (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15700 DLG2

Gene Names

DLG2

Chain

chain:1-870

Reference Genes

BioGPS Gene:1740 DLG2

COSMIC - genes:DLG2 DLG2

CTD Gene:1740 DLG2

dbSNP Gene:1740 DLG2

ENSEMBL:ENSG00000150672 DLG2

HGNC:2901 DLG2

KEGG:hsa:1740 DLG2

Monarch:1740 DLG2

NCBI Gene:1740 DLG2

OMIM:603583 DLG2

UCSC:Q15700 DLG2

Reference Transcript

Participates

as a member of

DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)

Other forms of this molecule

DLG2 [plasma membrane]

Inferred To

dlg-1 [cytosol] (Caenorhabditis elegans)

dlg2 [cytosol] (Danio rerio)

dlg2 [cytosol] (Xenopus tropicalis)

DLG2 [cytosol] (Canis familiaris)

DLG2 [cytosol] (Gallus gallus)

Dlg2 [cytosol] (Mus musculus)

Dlg2 [cytosol] (Rattus norvegicus)

dlg1 [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_001136172.1, NP_001136171.1, NP_001355.2, NP_001193698.1, NP_001136174.1

OpenTargets

ENSG00000150672

ENSEMBL

ENSG00000150672, ENST00000398309, ENST00000418306, ENST00000426717, ENST00000376104, ENSP00000393049, ENSP00000402275, ENSP00000365272, ENSP00000381355, ENST00000280241, ENSP00000280241

HPA

ENSG00000150672-DLG2

GeneCards

DLG2

PRO

Q15700

Pharos - Targets

Q15700

GlyGen

Q15700

PDB

2HE2, 2BYG

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95477 ABCA1	11	ABCA1 [plasma membrane] (R-HSA-194209) 4xPALM-C-p-2S-ABCA1 [plasma membrane] (R-HSA-5682069) 4xPALM-C-ABCA1 [endoplasmic reticulum membrane] (R-HSA-5682085) 4xPALM-C-ABCA1 [plasma membrane] (R-HSA-5682091) ABCA1 [endoplasmic reticulum membrane] (R-HSA-5682105) ABCA1 Q537R [plasma membrane] (R-HSA-5682199) ABCA1 R587W [plasma membrane] (R-HSA-5682197) ABCA1 S1446L [plasma membrane] (R-HSA-5682195) ABCA1 C1417R [plasma membrane] (R-HSA-5682190) ABCA1 N935S [plasma membrane] (R-HSA-5682200) ABCA1 W590S [plasma membrane] (R-HSA-5682201)	0.609	3
UniProt:Q13224 GRIN2B	6	GRIN2B [plasma membrane] (R-HSA-419558) p-Y-GRIN2B [plasma membrane] (R-HSA-9612185) GRIN2B [endoplasmic reticulum membrane] (R-HSA-9609765) GRIN2B [transport vesicle membrane] (R-HSA-9610568) p-Y1474-GRIN2B [plasma membrane] (R-HSA-9032602) p-Y1252,Y1336,Y1474-GRIN2B [plasma membrane] (R-HSA-3928477)	0.592	3
UniProt:Q7L5A8 FA2H	1	FA2H [endoplasmic reticulum membrane] (R-HSA-5693771)	0.556	3
UniProt:Q8WUA2 PPIL4	1	PPIL4 [nucleoplasm] (R-HSA-8952113)	0.556	3
UniProt:P04004 VTN	1	VTN [extracellular region] (R-HSA-215971)	0.556	3
UniProt:P24390 KDELR1	4	KDELR1 [endoplasmic reticulum membrane] (R-HSA-6813886) KDELR1 [Golgi membrane] (R-HSA-6808781) KDELR1 [transport vesicle] (R-HSA-6808782) KDELR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-6807760)	0.556	3
UniProt:Q9UIV8 SERPINB13	1	SERPINB13 [lysosomal lumen] (R-HSA-8938045)	0.556	3
UniProt:P62241 RPS8	2	RPS8 [cytosol] (R-HSA-72385) RPS8 [nucleoplasm] (R-HSA-6791203)	0.556	3
UniProt:P60484 PTEN	20	K48polyUb-PTEN [cytosol] (R-HSA-8874327) PolyUb-PTEN [nucleoplasm] (R-HSA-6782515) PTEN H93R [cytosol] (R-HSA-2318524) PTEN C124R [cytosol] (R-HSA-2317439) PTEN H93Y [cytosol] (R-HSA-2318520) PTEN R130G [cytosol] (R-HSA-2317339) PTEN H93D [cytosol] (R-HSA-2318550) PTEN R130L [cytosol] (R-HSA-2317430) PTEN H93A [cytosol] (R-HSA-2318544) PTEN G129E [cytosol] (R-HSA-2318509) PTEN S170N [cytosol] (R-HSA-2318408) PTEN R173P [cytosol] (R-HSA-2317480) PTEN R130Q [cytosol] (R-HSA-2317416) PTEN H93Q [cytosol] (R-HSA-2318565) PTEN G129R [cytosol] (R-HSA-2318501) PTEN H123Y [cytosol] (R-HSA-2318469) PTEN S170R [cytosol] (R-HSA-2318437) PTEN R173C [cytosol] (R-HSA-2317478) PTEN R173H [cytosol] (R-HSA-2317473) PTEN C124S [cytosol] (R-HSA-2317379)	0.544	3
UniProt:P98164 LRP2	2	LRP2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869099) LRP2 [plasma membrane] (R-HSA-350083)	0.527	2
UniProt:O60469 DSCAM	1	DSCAM [plasma membrane] (R-HSA-197881)	0.488	3