Reactome | PTEN E157* [cytosol]

PTEN E157* [cytosol]

Stable Identifier

R-HSA-9658926

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Pten Glu157*, PTEN E157TER, PTEN Glu157TER

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - PI3K/AKT Signaling in Cancer (Homo sapiens)
    - PTEN Loss of Function in Cancer (Homo sapiens)
      - PTEN cancer mutants do not dephosphorylate PIP3 (Homo sapiens)
        
        PTEN Mutants [cytosol] (Homo sapiens)
        
        PTEN Truncation Mutants [cytosol] (Homo sapiens)
        
        PTEN E157* [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P60484 PTEN

Gene Names

PTEN, MMAC1, TEP1

Chain

initiator methionine:, chain:2-403

Reference Genes

BioGPS Gene:5728 PTEN

COSMIC (genes):PTEN PTEN

COSMIC (genes):TEP1 PTEN

CTD Gene:5728 PTEN

dbSNP Gene:5728 PTEN

ENSEMBL:ENSG00000171862 PTEN

HGNC:9588 PTEN

KEGG:hsa:5728 PTEN

Monarch:5728 PTEN

NCBI Gene:5728 PTEN

OMIM:601728 PTEN

UCSC:P60484 PTEN

Reference Transcript

Participates

as a member of

PTEN Truncation Mutants [cytosol] (Homo sapiens)

Other forms of this molecule

K48polyUb-PTEN [cytosol]

PolyUb-PTEN [nucleoplasm]

PTEN H93R [cytosol]

PTEN C124R [cytosol]

PTEN H93Y [cytosol]

PTEN R130G [cytosol]

PTEN H93D [cytosol]

PTEN R130L [cytosol]

PTEN H93A [cytosol]

PTEN G129E [cytosol]

PTEN S170N [cytosol]

PTEN R173P [cytosol]

PTEN R130Q [cytosol]

PTEN H93Q [cytosol]

PTEN G129R [cytosol]

PTEN H123Y [cytosol]

PTEN S170R [cytosol]

PTEN R173C [cytosol]

PTEN R173H [cytosol]

PTEN C124S [cytosol]

PTEN C124Y [cytosol]

PTEN R130P [cytosol]

PTEN C124F [cytosol]

PTEN G129V [cytosol]

PTEN S170I [cytosol]

PTEN S170G [cytosol]

PTEN E99* [cytosol]

PTEN G165* [cytosol]

PTEN E150* [cytosol]

PTEN E43* [cytosol]

PTEN Q17* [cytosol]

PTEN E91* [cytosol]

PTEN S59* [cytosol]

PTEN E114* [cytosol]

PTEN L139* [cytosol]

PTEN Y176* [cytosol]

PTEN Y177* [cytosol]

PTEN Q149* [cytosol]

PTEN L146* [cytosol]

PTEN G20* [cytosol]

PTEN G127* [cytosol]

PTEN Y46* [cytosol]

PTEN L182* [cytosol]

PTEN Q97* [cytosol]

PTEN Q171* [cytosol]

PTEN G129* [cytosol]

PTEN E18* [cytosol]

PTEN Y180* [cytosol]

PTEN K163* [cytosol]

PTEN Y27* [cytosol]

PTEN Y65* [cytosol]

PTEN Y68* [cytosol]

PTEN K128* [cytosol]

PTEN Y138* [cytosol]

PTEN K125* [cytosol]

PTEN Y88* [cytosol]

PTEN Q110* [cytosol]

PTEN L23* [cytosol]

PTEN E7* [cytosol]

PTEN C105* [cytosol]

PTEN E73* [cytosol]

PTEN K62* [cytosol]

PTEN E40* [cytosol]

PTEN Y178* [cytosol]

PTEN R130* [cytosol]

PTEN W111* [cytosol]

PTEN R11* [cytosol]

PTEN K13* [cytosol]

PTEN Y174* [cytosol]

PTEN K147* [cytosol]

PTEN R84* [cytosol]

PTEN G293* [cytosol]

PTEN S287* [cytosol]

PTEN Q214* [cytosol]

PTEN S229* [cytosol]

PTEN Q219* [cytosol]

PTEN Q261* [cytosol]

PTEN E299* [cytosol]

PTEN Y336* [cytosol]

PTEN Q245* [cytosol]

PTEN Y225* [cytosol]

PTEN Y240* [cytosol]

PTEN C218* [cytosol]

PTEN C250* [cytosol]

PTEN L247* [cytosol]

PTEN G209* [cytosol]

PTEN C211* [cytosol]

PTEN G230* [cytosol]

PTEN Q298* [cytosol]

PTEN L320* [cytosol]

PTEN E242* [cytosol]

PTEN K332* [cytosol]

PTEN E284* [cytosol]

PTEN E291* [cytosol]

PTEN K330* [cytosol]

PTEN E314* [cytosol]

PTEN Y346* [cytosol]

PTEN C296* [cytosol]

PTEN W274* [cytosol]

PTEN R233* [cytosol]

PTEN R335* [cytosol]

PTEN [cytosol]

PTEN [nucleoplasm]

MonoUb-K13,K289-PTEN [nucleoplasm]

MonoUb-K13,K289-PTEN [cytosol]

K48polyUb-K289-PTEN [cytosol]

PolyUb-PTEN [cytosol]

K27polyUb-PTEN [cytosol]

p-3S,2T-PTEN [cytosol]

RibC-E40,E150,D326-PTEN [cytosol]

PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN [cytosol]

p-Y336-PTEN [cytosol]

PTEN K344* [cytosol]

PTEN K221* [cytosol]

PTEN E288* [cytosol]

PTEN E235* [cytosol]

PTEN K263* [cytosol]

PTEN E307* [cytosol]

PTEN R189* [cytosol]

PTEN E256* [cytosol]

Modified Residues

Name

Nonsense mutation at L-glutamic acid 157

Coordinate

157

PsiMod

L-glutamic acid removal [MOD:01636]

A protein modification that effectively removes or replaces an L-glutamic acid.

Disease

Name	Identifier	Synonyms
endometrial cancer	DOID:1380	primary malignant neoplasm of endometrium, neoplasm of endometrium (disorder), endometrial neoplasm, malignant endometrial neoplasm, endometrial Ca, malignant neoplasm of endometrium, tumor of Endometrium
melanoma	DOID:1909	Naevocarcinoma, melanoma, melanoma, malignant melanoma, morphology (morphologic abnormality), malignant melanoma NOS (morphologic abnormality), malignant melanoma (disorder), malignant melanoma, malignant melanoma, malignant melanoma, malignant melanoma
nasopharynx carcinoma	DOID:9261	malignant neoplasm of nasopharynx, malignant neoplasm of anterior wall of nasopharynx, malignant neoplasm of lateral wall of nasopharynx, malignant tumor of lateral wall of nasopharynx, Nasopharyngeal carcinoma, carcinoma of nasopharynx, malignant tumor of posterior wall of nasopharynx, malignant Nasopharyngeal tumor, malignant neoplasm of posterior wall of nasopharynx, malignant neoplasm of nasopharyngeal wall, malignant neoplasm of other specified sites of nasopharynx, primary malignant neoplasm of anterior wall of nasopharynx, malignant tumor of anterior wall of nasopharynx, malignant neoplasm of roof of nasopharynx, malignant neoplasm of superior wall of nasopharynx, nasopharynx cancer
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer
lung squamous cell carcinoma	DOID:3907	squamous cell carcinoma of lung (disorder), Epidermoid cell carcinoma of the lung

Cross References

RefSeq

NP_001291646.2, NP_001291647.1, NP_000305.3

Guide to Pharmacology - Targets

2497

OpenTargets

ENSG00000171862

ENSEMBL

ENST00000644628, ENST00000710385, ENST00000710387, ENSG00000171862, ENSP00000518244, ENST00000371953, ENSP00000494918, ENSP00000518242, ENSG00000284792, ENSP00000508752, ENST00000688308, ENSP00000361021

ZINC target

P60484

PRO

P60484

GlyGen

P60484

PDB

4O1V, 7PC7, 5BZZ, 8X3S, 7JVX, 7JTX, 5BUG, 1D5R, 2KYL, 7JUL, 7JUK, 5BZX

COSMIC

COSV64290058

GeneCards

PTEN

HPA

ENSG00000171862-PTEN

Pharos - Targets

P60484

Orphanet

PTEN

HMDB Protein

HMDBP01570

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14745 NHRF1			0.771	7
UniProt:P09619 PDGFRB	3	p-12Y-PDGFRB [plasma membrane] (R-HSA-186803) PDGFRB [plasma membrane] (R-HSA-186767) p-11Y-PDGFRB [plasma membrane] (R-HSA-8864039)	0.675	3
UniProt:Q15599 NHRF2			0.639	5
UniProt:P42685 FRK	4	p-Y387-FRK [cytosol] (R-HSA-8847965) FRK [azurophil granule lumen] (R-HSA-6799142) FRK [extracellular region] (R-HSA-6806235) FRK [specific granule lumen] (R-HSA-6801037)	0.639	7
UniProt:Q5TCQ9 MAGI3			0.633	6
UniProt:Q06830 PRDX1	3	PRDX1 [cytosol] (R-HSA-3341270) HOOS-C52-PRDX1 [cytosol] (R-HSA-5629198) p-T90-PRDX1 [cytosol] (R-HSA-8868564)	0.632	7
UniProt:P30260 CDC27	2	CDC27 [cytosol] (R-HSA-174073) CDC27 [nucleoplasm] (R-HSA-174175)	0.616	7
UniProt:P60484 PTEN	20	K48polyUb-PTEN [cytosol] (R-HSA-8874327) PolyUb-PTEN [nucleoplasm] (R-HSA-6782515) PTEN H93R [cytosol] (R-HSA-2318524) PTEN C124R [cytosol] (R-HSA-2317439) PTEN H93Y [cytosol] (R-HSA-2318520) PTEN R130G [cytosol] (R-HSA-2317339) PTEN H93D [cytosol] (R-HSA-2318550) PTEN R130L [cytosol] (R-HSA-2317430) PTEN H93A [cytosol] (R-HSA-2318544) PTEN G129E [cytosol] (R-HSA-2318509) PTEN S170N [cytosol] (R-HSA-2318408) PTEN R173P [cytosol] (R-HSA-2317480) PTEN R130Q [cytosol] (R-HSA-2317416) PTEN H93Q [cytosol] (R-HSA-2318565) PTEN G129R [cytosol] (R-HSA-2318501) PTEN H123Y [cytosol] (R-HSA-2318469) PTEN S170R [cytosol] (R-HSA-2318437) PTEN R173C [cytosol] (R-HSA-2317478) PTEN R173H [cytosol] (R-HSA-2317473) PTEN C124S [cytosol] (R-HSA-2317379)	0.615	9
UniProt:O43791 SPOP	1	SPOP [nucleoplasm] (R-HSA-5635035)	0.611	4
UniProt:P35226 BMI1	3	BMI1 [nucleoplasm] (R-HSA-389121) p-S-BMI1 [nucleoplasm] (R-HSA-3229116) monoSUMO1-K88-BMI1 [nucleoplasm] (R-HSA-4551729)	0.61	7
UniProt:Q9R1L5 MAST1			0.593	3
UniProt:O60307 MAST3			0.593	3
UniProt:Q60592 MAST2			0.593	4
UniProt:P46934 NEDD4	1	NEDD4 [cytosol] (R-HSA-975992)	0.591	4
UniProt:O88382 MAGI2			0.581	3
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.524	2
UniProt:Q9JHL1 NHRF2			0.524	2
UniProt:P21860 ERBB3			0.519	2
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.508	2
UniProt:Q9JK71 MAGI3			0.508	3
UniProt:Q9P0U4 CXXC1	1	CXXC1 [nucleoplasm] (R-HSA-535610)	0.508	2
UniProt:Q03135 CAV1	5	CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009) CAV1 [early endosome membrane] (R-HSA-5368451)	0.499	2
UniProt:Q9ULX6 AKAP8L	1	AKAP8L [nucleoplasm] (R-HSA-9821364)	0.499	2
UniProt:Q9UER7 DAXX	13	DAXX [nucleoplasm] (R-HSA-3222068) DAXX A36Qfs108 [nucleoplasm] (R-HSA-9673105) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX S138 [nucleoplasm] (R-HSA-9673081) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.483	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477)	0.483	2
UniProt:Q16643 DBN1	1	DBN1 [cytosol] (R-HSA-9714666)	0.471	5
UniProt:Q9UJX3 ANAPC7	2	ANAPC7 [cytosol] (R-HSA-174242) ANAPC7 [nucleoplasm] (R-HSA-174204)	0.462	2
UniProt:Q9UJX5 ANAPC4	2	ANAPC4 [cytosol] (R-HSA-174168) ANAPC4 [nucleoplasm] (R-HSA-174115)	0.462	2
UniProt:Q9UJX4 ANAPC5	2	ANAPC5 [cytosol] (R-HSA-174211) ANAPC5 [nucleoplasm] (R-HSA-174153)	0.462	2

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