Reactome | HTRA1 [extracellular region]

HTRA1 [extracellular region]

Stable Identifier

R-HSA-8855820

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Serine protease HTRA1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q92743 HTRA1

Gene Names

HTRA1, HTRA, PRSS11

Chain

signal peptide:1-22, chain:23-480

Reference Genes

BioGPS Gene:5654 HTRA1

COSMIC (genes):HTRA1 HTRA1

CTD Gene:5654 HTRA1

dbSNP Gene:5654 HTRA1

ENSEMBL:ENSG00000166033 HTRA1

HGNC:9476 HTRA1

Monarch:5654 HTRA1

NCBI Gene:5654 HTRA1

OMIM:602194 HTRA1

UCSC:Q92743 HTRA1

Reference Transcript

RefSeq:NM_002775.4 HTRA1

Other Identifiers

11716405_a_at

11747787_a_at

16710126

201185_PM_at

201185_at

3268334

3268335

3268336

3268337

3268338

3268339

3268340

3268341

3268355

3268356

3268357

3268366

3268367

3268369

3268373

3268374

3268375

4037764

4037765

4037766

4037767

4037769

4037773

4037774

4037775

48727_at

5654

718_at

719_g_at

7931097

A_23_P97990

D87258_at

GE79387

GO:0001890

GO:0003824

GO:0004252

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005829

GO:0005886

GO:0006508

GO:0008233

GO:0008236

GO:0012501

GO:0016787

GO:0019838

GO:0030154

GO:0030312

GO:0030512

GO:0030514

GO:0031012

GO:0042802

GO:0043065

GO:0043226

GO:0048856

GO:0060718

GO:0062023

GO:0070062

GO:0098772

GO:0140096

GO:0140677

HMNXSV003038773

ILMN_1676563

PH_hs_0027682

TC10000889.hg

g4506140_3p_at

Participates

as a component of

HTRA1 trimer [extracellular region] (Homo sapiens)

Inferred To

HTRA1 [extracellular region] (Bos taurus)

HTRA1 [extracellular region] (Canis familiaris)

HTRA1 [extracellular region] (Gallus gallus)

HTRA1 [extracellular region] (Sus scrofa)

Htra1 [extracellular region] (Mus musculus)

Htra1 [extracellular region] (Rattus norvegicus)

Cross References

Guide to Pharmacology - Targets

3194

ENSEMBL

ENST00000368984, ENSP00000357980

OpenTargets

ENSG00000166033

HPA

ENSG00000166033-HTRA1

PRO

Q92743

Pharos - Targets

Q92743

Orphanet

HTRA1

HMDB Protein

HMDBP14536

PDB

3TJO, 6Z0X, 2JOA, 6Z0Y, 3NUM, 3NZI, 3TJN, 6Z0E, 3NWU, 3TJQ, 7SJO, 2YTW, 7SJP, 7SJN

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.751	9
UniProt:P01185 AVP	10	AVP(20-28) [extracellular region] (R-HSA-388474) AVP(20-28) [cytosol] (R-HSA-879509) AVP E47del [extracellular region] (R-HSA-5621396) AVP P7L [extracellular region] (R-HSA-5621460) AVP C67* [extracellular region] (R-HSA-5621431) AVP V67A [extracellular region] (R-HSA-5621446) AVP A1T [extracellular region] (R-HSA-5621473) AVP Y2H [extracellular region] (R-HSA-5621449) AVP G23R [extracellular region] (R-HSA-5621464) AVP(20-28) [clathrin-coated endocytic vesicle membrane] (R-HSA-8869075)	0.527	2
UniProt:Q01523 DEFA5	5	DEFA5(1-94) [Golgi lumen] (R-HSA-1467267) DEFA5(20-94) [Golgi lumen] (R-HSA-1467208) DEFA5(20-94) [secretory granule lumen] (R-HSA-1471358) DEFA5(20-94) [extracellular region] (R-HSA-1471344) DEFA5(?-94) [extracellular region] (R-HSA-1462017)	0.527	2
UniProt:P19526 FUT1	1	FUT1 [Golgi membrane] (R-HSA-9034059)	0.527	2
UniProt:P14174 MIF	3	MIF [secretory granule lumen] (R-HSA-6803282) MIF [extracellular region] (R-HSA-212594) MIF [ficolin-1-rich granule lumen] (R-HSA-6803289)	0.527	3

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