PTEN W274* [cytosol]

Stable Identifier
R-HSA-9659393
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Pten Trp274*, PTEN W274TER, PTEN Trp274TER
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:P60484 PTEN
Gene Names
PTEN, MMAC1, TEP1
Chain
initiator methionine:1, chain:2-403
Reference Genes
BioGPS Gene:5728 PTEN
COSMIC - genes:PTEN PTEN
COSMIC - genes:TEP1 PTEN
CTD Gene:5728 PTEN
dbSNP Gene:5728 PTEN
ENSEMBL:ENSG00000171862 PTEN
HGNC:9588 PTEN
KEGG:hsa:5728 PTEN
Monarch:5728 PTEN
NCBI Gene:5728 PTEN
OMIM:601728 PTEN
UCSC:P60484 PTEN
Reference Transcript
Participates
as a candidate of
Other forms of this molecule
K48polyUb-PTEN [cytosol]
PolyUb-PTEN [nucleoplasm]
PTEN H93R [cytosol]
PTEN C124R [cytosol]
PTEN H93Y [cytosol]
PTEN R130G [cytosol]
PTEN H93D [cytosol]
PTEN R130L [cytosol]
PTEN H93A [cytosol]
PTEN G129E [cytosol]
PTEN S170N [cytosol]
PTEN R173P [cytosol]
PTEN R130Q [cytosol]
PTEN H93Q [cytosol]
PTEN G129R [cytosol]
PTEN H123Y [cytosol]
PTEN S170R [cytosol]
PTEN R173C [cytosol]
PTEN R173H [cytosol]
PTEN C124S [cytosol]
PTEN C124Y [cytosol]
PTEN R130P [cytosol]
PTEN C124F [cytosol]
PTEN G129V [cytosol]
PTEN S170I [cytosol]
PTEN S170G [cytosol]
PTEN E99* [cytosol]
PTEN G165* [cytosol]
PTEN E157* [cytosol]
PTEN E150* [cytosol]
PTEN E43* [cytosol]
PTEN Q17* [cytosol]
PTEN E91* [cytosol]
PTEN S59* [cytosol]
PTEN E114* [cytosol]
PTEN L139* [cytosol]
PTEN Y176* [cytosol]
PTEN Y177* [cytosol]
PTEN Q149* [cytosol]
PTEN L146* [cytosol]
PTEN G20* [cytosol]
PTEN G127* [cytosol]
PTEN Y46* [cytosol]
PTEN L182* [cytosol]
PTEN Q97* [cytosol]
PTEN Q171* [cytosol]
PTEN G129* [cytosol]
PTEN E18* [cytosol]
PTEN Y180* [cytosol]
PTEN K163* [cytosol]
PTEN Y27* [cytosol]
PTEN Y65* [cytosol]
PTEN Y68* [cytosol]
PTEN K128* [cytosol]
PTEN Y138* [cytosol]
PTEN K125* [cytosol]
PTEN Y88* [cytosol]
PTEN Q110* [cytosol]
PTEN L23* [cytosol]
PTEN E7* [cytosol]
PTEN C105* [cytosol]
PTEN E73* [cytosol]
PTEN K62* [cytosol]
PTEN E40* [cytosol]
PTEN Y178* [cytosol]
PTEN R130* [cytosol]
PTEN W111* [cytosol]
PTEN R11* [cytosol]
PTEN K13* [cytosol]
PTEN Y174* [cytosol]
PTEN K147* [cytosol]
PTEN R84* [cytosol]
PTEN G293* [cytosol]
PTEN S287* [cytosol]
PTEN Q214* [cytosol]
PTEN S229* [cytosol]
PTEN Q219* [cytosol]
PTEN Q261* [cytosol]
PTEN E299* [cytosol]
PTEN Y336* [cytosol]
PTEN Q245* [cytosol]
PTEN Y225* [cytosol]
PTEN Y240* [cytosol]
PTEN C218* [cytosol]
PTEN C250* [cytosol]
PTEN L247* [cytosol]
PTEN G209* [cytosol]
PTEN C211* [cytosol]
PTEN G230* [cytosol]
PTEN Q298* [cytosol]
PTEN L320* [cytosol]
PTEN E242* [cytosol]
PTEN K332* [cytosol]
PTEN E284* [cytosol]
PTEN E291* [cytosol]
PTEN K330* [cytosol]
PTEN E314* [cytosol]
PTEN Y346* [cytosol]
PTEN C296* [cytosol]
PTEN R233* [cytosol]
PTEN R335* [cytosol]
PTEN [cytosol]
PTEN [nucleoplasm]
MonoUb-K13,K289-PTEN [nucleoplasm]
MonoUb-K13,K289-PTEN [cytosol]
K48polyUb-K289-PTEN [cytosol]
PolyUb-PTEN [cytosol]
K27polyUb-PTEN [cytosol]
p-3S,2T-PTEN [cytosol]
RibC-E40,E150,D326-PTEN [cytosol]
PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN [cytosol]
p-Y336-PTEN [cytosol]
PTEN K344* [cytosol]
PTEN K221* [cytosol]
PTEN E288* [cytosol]
PTEN E235* [cytosol]
PTEN K263* [cytosol]
PTEN E307* [cytosol]
PTEN R189* [cytosol]
PTEN E256* [cytosol]
Modified Residues
Name
Nonsense mutation at L-tryptophan 274
Coordinate
274
PsiMod
L-tryptophan removal [MOD:01648]
A protein modification that effectively removes or replaces an L-tryptophan.
Disease
Name Identifier Synonyms
endometrial cancer DOID:1380 primary malignant neoplasm of endometrium, neoplasm of endometrium (disorder), endometrial neoplasm, malignant endometrial neoplasm, endometrial Ca, malignant neoplasm of endometrium, tumor of Endometrium
melanoma DOID:1909 Naevocarcinoma, melanoma, melanoma, malignant melanoma, morphology (morphologic abnormality), malignant melanoma NOS (morphologic abnormality), malignant melanoma (disorder), malignant melanoma, malignant melanoma, malignant melanoma, malignant melanoma
acute lymphocytic leukemia DOID:9952
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
breast cancer DOID:1612 malignant tumor of the breast, mammary cancer, malignant neoplasm of breast, mammary tumor, primary breast cancer, breast cancer, Ca breast - NOS, breast tumor
gliosarcoma DOID:3071 Glioblastoma with sarcomatous component
prostate cancer DOID:10283 NGP - New growth of prostate, neoplasm of prostate (disorder), tumor of the prostate, malignant tumor of prostate (disorder), prostate neoplasm, malignant tumor of the prostate, malignant tumor of prostate (disorder), prostatic cancer, prostatic neoplasm
astrocytoma DOID:3069 astrocytoma of Cerebrum, Astrocytic tumor, astrocytoma of brain (disorder), astroglioma, astrocytoma, no ICD-O subtype (morphologic abnormality), cerebral astrocytoma
Cross References
RefSeq
Guide to Pharmacology - Targets
OpenTargets
ENSEMBL
Mondo
ZINC target
PRO
GlyGen
PDB
COSMIC
IntEnz
GeneCards
HPA
Pharos - Targets
Orphanet
HMDB Protein
Interactors (49)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:O14745 NHRF1      0.826 9
 UniProt:Q5TCQ9 MAGI3      0.747 9
 UniProt:Q15599 NHRF2      0.733 6
 UniProt:P60484 PTEN  20 0.713 19
 UniProt:O60307 MAST3      0.698 4
 UniProt:P09619 PDGFRB  3 0.675 3
 UniProt:P42685 FRK  4 0.639 7
 UniProt:Q06830 PRDX1  4 0.632 7
 UniProt:P30260 CDC27  2 0.616 7
 UniProt:Q9HD26 GOPC  3 0.611 4
 UniProt:Q86UL8 MAGI2  1 0.611 7
 UniProt:Q96L92 SNX27      0.611 4
 UniProt:Q13424 SNTA1  1 0.611 4
 UniProt:Q6P0Q8 MAST2      0.611 4
 UniProt:Q9NZN5-2 ARHGEF12      0.611 4
 UniProt:Q92743 HTRA1  1 0.611 4
 UniProt:Q9H5P4 PDZD7      0.611 4
 UniProt:A4D2P6 GRD2I      0.611 6
 UniProt:Q9Y2H9 MAST1      0.611 4
 UniProt:Q9NY99 SNTG2  1 0.611 3
 UniProt:Q13884 SNTB1  1 0.611 5
 UniProt:Q14160 SCRIB  1 0.611 5
 UniProt:O43791 SPOP  3 0.611 4
 UniProt:P35226 BMI1  3 0.61 7
 UniProt:Q9R1L5 MAST1      0.593 3
 UniProt:Q60592 MAST2      0.593 4
 UniProt:P46934 NEDD4  1 0.591 4
 UniProt:O88382 MAGI2      0.581 3
 UniProt:Q96QZ7 MAGI1      0.544 8
 UniProt:O75970 MPDZ      0.544 7
 UniProt:Q12923 PTPN13  2 0.544 3
 UniProt:Q07157 TJP1  6 0.544 5
 UniProt:Q15700 DLG2  2 0.544 3
 UniProt:Q8NI35 PATJ  1 0.544 10
 UniProt:P62136 PPP1CA  2 0.524 2
 UniProt:Q9JHL1 NHRF2      0.524 2
 UniProt:P21860 ERBB3      0.519 2
 UniProt:Q9NRD5 PICK1  2 0.508 2
 UniProt:Q9JK71 MAGI3      0.508 3
 UniProt:Q9P0U4 CXXC1  1 0.508 2
 UniProt:Q9ULX6 AKAP8L  1 0.499 2
 UniProt:Q93009 USP7  2 0.499 2
 UniProt:Q03135 CAV1  5 0.499 2
 UniProt:P08238 HSP90AB1  6 0.483 2
 UniProt:Q9UER7 DAXX  13 0.483 2
 UniProt:Q16643 DBN1  1 0.471 5
 UniProt:Q9UJX3 ANAPC7  2 0.462 2
 UniProt:Q9UJX5 ANAPC4  2 0.462 2
 UniProt:Q9UJX4 ANAPC5  2 0.462 2
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