Reactome | ANAPC5 [cytosol]

ANAPC5 [cytosol]

Stable Identifier

R-HSA-174211

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Apc5

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - Mitotic Spindle Checkpoint (Homo sapiens)
    - Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Homo sapiens)
      - Inactivation of APC/C via direct inhibition of the APC/C complex (Homo sapiens)
        
        Binding of the MCC complex to the APC/C complex (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Separation of Sister Chromatids (Homo sapiens)
        
        Association of Securin with Cdc20:APC/C complex (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        Degradation of multiubiquitinated Securin (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Homo sapiens)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
        
        Association of cell cycle proteins with the APC/C:Cdh1 complex (Homo sapiens)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        Degradation of multiubiquitinated cell cycle proteins (Homo sapiens)
        
        multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Homo sapiens)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
        
        APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
        
        APC/C:Cdc20 mediated degradation of Cyclin B (Homo sapiens)
        
        Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        Degradation of multiubiquitinated Cyclin B (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Homo sapiens)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Homo sapiens)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Homo sapiens)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        APC/C:Cdc20 mediated degradation of Securin (Homo sapiens)
        
        Association of Securin with Cdc20:APC/C complex (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        Degradation of multiubiquitinated Securin (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Homo sapiens)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Homo sapiens)
        
        APC-Cdc20 mediated degradation of Nek2A (Homo sapiens)
        
        Association of Nek2A with MCC:APC/C (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        Nek2A:MCC:APC/C complex [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        Degradation of multiubiquitinated Nek2A (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        Multiubiquitinated Nek2A [cytosol] (Homo sapiens)
        
        Nek2A:MCC:APC/C complex [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        Multiubiquitination of Nek2A (Homo sapiens)
        
        Multiubiquitinated Nek2A [cytosol] (Homo sapiens)
        
        Nek2A:MCC:APC/C complex [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        Nek2A:MCC:APC/C complex [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Homo sapiens)
        
        Association of Cyclin A with the APC/C (Homo sapiens)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        Degradation multiubiquitinated Cyclin A (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Homo sapiens)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Homo sapiens)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Homo sapiens)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
      - Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Homo sapiens)
        
        Association of Cdh1 with the APC/C (Homo sapiens)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        Dissociation of Cdc20 from APC/C complex (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
      - Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
        
        Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Homo sapiens)
        
        Inactivation of APC/C via direct inhibition of the APC/C complex (Homo sapiens)
        
        Binding of the MCC complex to the APC/C complex (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
  - S Phase (Homo sapiens)
    - Synthesis of DNA (Homo sapiens)
      - Switching of origins to a post-replicative state (Homo sapiens)
        
        CDK-mediated phosphorylation and removal of Cdc6 (Homo sapiens)
        
        Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Homo sapiens)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Class I MHC mediated antigen processing & presentation (Homo sapiens)
    - Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
      - Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        APC/C E3 ligase complex [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        APC/C E3 ligase complex [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
      - Polyubiquitination of substrate (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        APC/C E3 ligase complex [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        APC/C E3 ligase complex [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        E3:Ub:substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        APC/C E3 ligase complex [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
      - Release of E3 from polyubiquitinated substrate (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        APC/C E3 ligase complex [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        APC/C E3 ligase complex [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
      - Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        APC/C E3 ligase complex [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        APC/C E3 ligase complex [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)
        
        E3:Ub:substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        APC/C E3 ligase complex [cytosol] (Homo sapiens)
        
        ANAPC5 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UJX4 ANAPC5

Gene Names

ANAPC5, APC5

Chain

chain:1-755

Reference Genes

BioGPS Gene:51433 ANAPC5

COSMIC (genes):ANAPC5 ANAPC5

CTD Gene:51433 ANAPC5

dbSNP Gene:51433 ANAPC5

ENSEMBL:ENSG00000089053 ANAPC5

ENSEMBL:ENSG00000089053.13 ANAPC5

HGNC:15713 ANAPC5

KEGG Gene (Homo sapiens):51433 ANAPC5

Monarch:51433 ANAPC5

NCBI Gene:51433 ANAPC5

OMIM:606948 ANAPC5

UCSC:Q9UJX4 ANAPC5

Reference Transcript

Other Identifiers

11715599_a_at

16771463

18670994

18670995

18670996

18671001

18671002

18671004

18671005

18671006

18671009

18671011

18671012

18671013

18671015

18671017

18671019

18671020

18671021

18671022

18671025

18671026

18671028

200098_PM_s_at

200098_s_at

208721_PM_s_at

208721_s_at

208722_PM_s_at

208722_s_at

211036_PM_x_at

211036_x_at

3474936

3474937

3474938

3474939

3474940

3474948

3474950

3474951

3474952

3474958

3474960

3474964

3474968

3474974

3474975

3474976

3474977

3474979

3474981

3474983

3474984

3474985

35835_at

51433

7893097

7893346

7893593

7893821

7893856

7893908

7893948

7894295

7894316

7894574

7894665

7894711

7895032

7895042

7895438

7895548

7895658

7896205

7896241

7896269

7896627

7967149

90637_at

A_23_P204448

GE62916

GE79326

GO:0000278

GO:0005515

GO:0005634

GO:0005654

GO:0005680

GO:0005737

GO:0005819

GO:0005829

GO:0005856

GO:0007049

GO:0007059

GO:0007346

GO:0016567

GO:0019903

GO:0022414

GO:0030163

GO:0031145

GO:0036211

GO:0043226

GO:0045842

GO:0051301

GO:0051445

GO:0070979

GO:0140014

HMNXSV003049276

Hs.7101.0.S1_3p_s_at

ILMN_1723177

PH_hs_0000724

TC12002062.hg

g12654502_3p_s_at

Participates

as a component of

Other forms of this molecule

ANAPC5 [nucleoplasm]

Inferred To

gfi-3 [cytosol] (Caenorhabditis elegans)

Anapc5 [cytosol] (Mus musculus)

Anapc5 [cytosol] (Rattus norvegicus)

anapc5 [cytosol] (Dictyostelium discoideum)

anapc5 [cytosol] (Xenopus tropicalis)

ida [cytosol] (Drosophila melanogaster)

ANAPC5 [cytosol] (Bos taurus)

ANAPC5 [cytosol] (Canis familiaris)

ANAPC5 [cytosol] (Danio rerio)

ANAPC5 [cytosol] (Gallus gallus)

ANAPC5 [cytosol] (Sus scrofa)

apc5 [cytosol] (Schizosaccharomyces pombe)

APC5 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001317418.1, NP_001131031.1, NP_057321.2

OpenTargets

ENSG00000089053

GeneCards

Q9UJX4

HPA

ENSG00000089053-ANAPC5

Ensembl

ENSP00000261819, ENST00000261819, ENSP00000415061, ENSG00000089053, ENST00000441917

PRO

Q9UJX4

Pharos - Targets

Q9UJX4

PDB

5LCW, 6TNT, 5L9U, 6TM5, 4UI9, 5L9T, 6Q6H, 5A31, 5G05, 5G04, 5KHU, 5KHR, 6TLJ, 7QE7, 6Q6G

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9JJ66	3	Cdc20 [nucleoplasm] (R-MMU-6783069) Cdc20 [nucleoplasm] (R-MMU-174112) Cdc20 [cytosol] (R-MMU-141412)	0.564	2
UniProt:P60484 PTEN	20	K48polyUb-PTEN [cytosol] (R-HSA-8874327) PolyUb-PTEN [nucleoplasm] (R-HSA-6782515) PTEN H93R [cytosol] (R-HSA-2318524) PTEN C124R [cytosol] (R-HSA-2317439) PTEN H93Y [cytosol] (R-HSA-2318520) PTEN R130G [cytosol] (R-HSA-2317339) PTEN H93D [cytosol] (R-HSA-2318550) PTEN R130L [cytosol] (R-HSA-2317430) PTEN H93A [cytosol] (R-HSA-2318544) PTEN G129E [cytosol] (R-HSA-2318509) PTEN S170N [cytosol] (R-HSA-2318408) PTEN R173P [cytosol] (R-HSA-2317480) PTEN R130Q [cytosol] (R-HSA-2317416) PTEN H93Q [cytosol] (R-HSA-2318565) PTEN G129R [cytosol] (R-HSA-2318501) PTEN H123Y [cytosol] (R-HSA-2318469) PTEN S170R [cytosol] (R-HSA-2318437) PTEN R173C [cytosol] (R-HSA-2317478) PTEN R173H [cytosol] (R-HSA-2317473) PTEN C124S [cytosol] (R-HSA-2317379)	0.462	2

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