RNF146 polyubiquitinates PARylated PTEN

Stable Identifier
R-HSA-8948832
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
RNF146 polyubiquitinates PARylated PTEN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The E3 ubiquitin ligase RNF146 possesses a PAR recognition domain (WWE) which binds to PARylated PTEN. RNF146 polyubiquitinates PARylated PTEN, with lysine residues K342, K344 and K349 as major ubiquitination sites. RNF146-mediated ubiquitination targets PTEN for proteasome-mediated degradation (Li et al. 2015).

Literature References
PubMed ID Title Journal Year
25547115 Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth

Yang, L, Lin, C, Wang, W, Li, N, Chen, J, Songyang, Z, Feng, L, Zhang, Y, Liang, K, Wang, J, Yu, Y, Han, X

Genes Dev. 2015
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ubiquitin protein ligase activity of RNF146 [cytosol]

Physical Entity
RNF146 [cytosol] (Homo sapiens)
Activity
ubiquitin protein ligase activity (GO:0061630)
Orthologous Events
RNF146 polyubiquitinates PARylated PTEN (Bos taurus)
RNF146 polyubiquitinates PARylated PTEN (Canis familiaris)
RNF146 polyubiquitinates PARylated PTEN (Danio rerio)
RNF146 polyubiquitinates PARylated PTEN (Drosophila melanogaster)
RNF146 polyubiquitinates PARylated PTEN (Gallus gallus)
RNF146 polyubiquitinates PARylated PTEN (Mus musculus)
RNF146 polyubiquitinates PARylated PTEN (Rattus norvegicus)
RNF146 polyubiquitinates PARylated PTEN (Sus scrofa)
Authored
Salmena, L  (2016-08-11)
Carracedo, A  (2016-08-11)
Orlic-Milacic, M  (2016-11-16)
Created
Orlic-Milacic, M  (2016-11-17)
Cite Us!