Reactome | ANAPC7 [nucleoplasm]

ANAPC7 [nucleoplasm]

Stable Identifier

R-HSA-174204

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Apc7

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of mitotic cell cycle (Homo sapiens)
  - Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
    - Aberrant regulation of mitotic exit in cancer due to RB1 defects (Homo sapiens)
      - Defective RB1 does not form a complex with SKP2 and FZR1 (Homo sapiens)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
        
        ANAPC7 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by VENTX (Homo sapiens)
      - Regulation of IL6 transcription (Homo sapiens)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
        
        ANAPC7 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UJX3 ANAPC7

Gene Names

ANAPC7, APC7

Chain

chain:1-565

Reference Genes

COSMIC (genes):ANAPC7 ANAPC7

ENSEMBL:ENSG00000196510 ANAPC7

ENSEMBL_homo_sapiens_GENE:ENSG00000196510.14 ANAPC7

HGNC:17380 ANAPC7

OMIM:606949 ANAPC7

UCSC:Q9UJX3 ANAPC7

Other Identifiers

11726620_at

11735948_a_at

11757527_a_at

16770040

225521_PM_at

225521_at

225554_PM_s_at

225554_s_at

4091260

4103353

4130099

45808_at

50144_at

51434

63079_at

7966301

A_23_P44643

GE58710

GO:0000278

GO:0000792

GO:0005515

GO:0005634

GO:0005654

GO:0005680

GO:0005694

GO:0005737

GO:0005819

GO:0005829

GO:0005856

GO:0007049

GO:0007059

GO:0007346

GO:0007420

GO:0015630

GO:0016567

GO:0019903

GO:0022414

GO:0030163

GO:0031145

GO:0036211

GO:0043226

GO:0045842

GO:0048856

GO:0051301

GO:0051445

GO:0060090

GO:0070979

GO:0140014

GO:0140767

HMNXSV003029021

HMNXSV003042565

HMNXSV003046057

Hs.52763.0.S1_3p_at

Hs.52763.1.A2_3p_a_at

ILMN_2199284

PH_hs_0027652

TC12003221.hg

Participates

as a component of

Other forms of this molecule

ANAPC7 [cytosol]

Inferred To

APC7 [nucleoplasm] (Drosophila melanogaster)

anapc7 [nucleoplasm] (Dictyostelium discoideum)

anapc7 [nucleoplasm] (Xenopus tropicalis)

ANAPC7 [nucleoplasm] (Bos taurus)

ANAPC7 [nucleoplasm] (Canis familiaris)

ANAPC7 [nucleoplasm] (Gallus gallus)

ANAPC7 [nucleoplasm] (Sus scrofa)

Anapc7 [nucleoplasm] (Mus musculus)

Anapc7 [nucleoplasm] (Rattus norvegicus)

Cross References

OpenTargets

ENSG00000196510

HPA

ENSG00000196510-ANAPC7

GeneCards

Q9UJX3

Ensembl

ENST00000450008, ENST00000455511, ENSP00000394394, ENSP00000402314, ENSG00000196510

PRO

Q9UJX3

Pharos - Targets

Q9UJX3

PDB

8TAU, 6Q6G, 6TM5, 6TNT, 6Q6H, 8PKP, 5KHU, 8TAR, 5L9T, 3FFL, 5LCW, 5A31, 4UI9, 5KHR, 5L9U, 7QE7, 5G05, 6TLJ, 5G04

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60566 BUB1B	1	BUB1B [cytosol] (R-HSA-141436)	0.669	3
UniProt:Q9JJ66	3	Cdc20 [nucleoplasm] (R-MMU-6783069) Cdc20 [nucleoplasm] (R-MMU-174112) Cdc20 [cytosol] (R-MMU-141412)	0.564	2
UniProt:P11440 Cdk1	11	phospho-p-T161-CDK1 [nucleoplasm] (R-MMU-170066) phospho-p-T14,Y15,T161-CDK1 [nucleoplasm] (R-MMU-170074) phospho-p-T161-CDK1 [cytosol] (R-MMU-157415) phospho-p-T14,Y15,T161-CDK1 [cytosol] (R-MMU-170071) CDK1 [cytosol] (R-MMU-170075) phospho-p-T14-CDK1 [cytosol] (R-MMU-170064) phospho-p-T14-CDK1 [nucleoplasm] (R-MMU-170045) Cdk1 [nucleoplasm] (R-MMU-1362302) phospho-p-T14,T161-CDK1 [nucleoplasm] (R-MMU-170078) phospho-p-Y4-CDK1 [cytosol] (R-MMU-9836187) CDK1 [endoplasmic reticulum membrane] (R-MMU-264424)	0.499	2
UniProt:P60484 PTEN	20	K48polyUb-PTEN [cytosol] (R-HSA-8874327) PolyUb-PTEN [nucleoplasm] (R-HSA-6782515) PTEN H93R [cytosol] (R-HSA-2318524) PTEN C124R [cytosol] (R-HSA-2317439) PTEN H93Y [cytosol] (R-HSA-2318520) PTEN R130G [cytosol] (R-HSA-2317339) PTEN H93D [cytosol] (R-HSA-2318550) PTEN R130L [cytosol] (R-HSA-2317430) PTEN H93A [cytosol] (R-HSA-2318544) PTEN G129E [cytosol] (R-HSA-2318509) PTEN S170N [cytosol] (R-HSA-2318408) PTEN R173P [cytosol] (R-HSA-2317480) PTEN R130Q [cytosol] (R-HSA-2317416) PTEN H93Q [cytosol] (R-HSA-2318565) PTEN G129R [cytosol] (R-HSA-2318501) PTEN H123Y [cytosol] (R-HSA-2318469) PTEN S170R [cytosol] (R-HSA-2318437) PTEN R173C [cytosol] (R-HSA-2317478) PTEN R173H [cytosol] (R-HSA-2317473) PTEN C124S [cytosol] (R-HSA-2317379)	0.462	2

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