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SYK [cytosol]
Stable Identifier
R-CFA-58268
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
SYK, A0A8I3P3G0
Locations in the PathwayBrowser
Expand all
Hemostasis (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
GPVI-mediated activation cascade (Canis familiaris)
Binding of Syk tyrosine kinase (Canis familiaris)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Canis familiaris)
SYK [cytosol] (Canis familiaris)
SYK [cytosol] (Canis familiaris)
GPVI stimulates PI3K beta, gamma (Canis familiaris)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Canis familiaris)
SYK [cytosol] (Canis familiaris)
PLC gamma 2-mediated PIP2 hydrolysis (Canis familiaris)
p-Y7-CLEC1B dimer:PDPN:SYK [plasma membrane] (Canis familiaris)
SYK [cytosol] (Canis familiaris)
SYK autophosphorylates (Canis familiaris)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Canis familiaris)
SYK [cytosol] (Canis familiaris)
SYK [cytosol] (Canis familiaris)
p-Y7-CLEC1B dimer:PDPN binds SYK (Canis familiaris)
SYK [cytosol] (Canis familiaris)
p-Y7-CLEC1B dimer:PDPN:SYK [plasma membrane] (Canis familiaris)
SYK [cytosol] (Canis familiaris)
Platelet Aggregation (Plug Formation) (Canis familiaris)
Integrin signaling (Canis familiaris)
SYK activation by SRC (Canis familiaris)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
SYK [cytosol] (Canis familiaris)
SYK binds to integrin alphaIIb beta3 (Canis familiaris)
SYK [cytosol] (Canis familiaris)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
SYK [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Canis familiaris)
SYK autophosphorylates at the activated BCR (Canis familiaris)
Antigen:p-BCR:SYK [plasma membrane] (Canis familiaris)
SYK [cytosol] (Canis familiaris)
SYK binds the activated BCR (Canis familiaris)
Antigen:p-BCR:SYK [plasma membrane] (Canis familiaris)
SYK [cytosol] (Canis familiaris)
SYK [cytosol] (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
FLT3 Signaling (Canis familiaris)
FLT3 signaling through SRC family kinases (Canis familiaris)
Active FLT3 binds to SYK (Canis familiaris)
SYK [cytosol] (Canis familiaris)
active FLT3:SYK [plasma membrane] (Canis familiaris)
SYK [cytosol] (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-2 family signaling (Canis familiaris)
Interleukin-2 signaling (Canis familiaris)
SYK binds IL2RB (Canis familiaris)
IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Canis familiaris)
SYK [cytosol] (Canis familiaris)
SYK [cytosol] (Canis familiaris)
SYK is a substrate for JAK1 (Canis familiaris)
IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Canis familiaris)
SYK [cytosol] (Canis familiaris)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Canis familiaris)
Regulation of signaling by CBL (Canis familiaris)
CBL ubiquitinates PI3K (Canis familiaris)
FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
FYN-like kinases [cytosol] (Canis familiaris)
SYK [cytosol] (Canis familiaris)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
FYN-like kinases [cytosol] (Canis familiaris)
SYK [cytosol] (Canis familiaris)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Canis familiaris)
FYN-like kinases [cytosol] (Canis familiaris)
SYK [cytosol] (Canis familiaris)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
FYN-like kinases [cytosol] (Canis familiaris)
SYK [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
C-type lectin receptors (CLRs) (Canis familiaris)
Dectin-2 family (Canis familiaris)
SYK autophosphorylates (Canis familiaris)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] (Canis familiaris)
SYK [cytosol] (Canis familiaris)
SYK binds to p-Y65,Y76-FCER1G (Canis familiaris)
SYK [cytosol] (Canis familiaris)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] (Canis familiaris)
SYK [cytosol] (Canis familiaris)
DAP12 interactions (Canis familiaris)
DAP12 signaling (Canis familiaris)
Phosphorylation of SYK (Canis familiaris)
DAP12 receptors:p-DAP12:SYK [plasma membrane] (Canis familiaris)
SYK [cytosol] (Canis familiaris)
SYK [cytosol] (Canis familiaris)
Recruitment of SYK to p-DAP12 (Canis familiaris)
DAP12 receptors:p-DAP12:SYK [plasma membrane] (Canis familiaris)
SYK [cytosol] (Canis familiaris)
SYK [cytosol] (Canis familiaris)
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
Recruitment of SYK to p-FCERI gamma subunit (Canis familiaris)
Clustered p:LYN:p-FCERI:IgE:allergen:SYK [plasma membrane] (Canis familiaris)
SYK [cytosol] (Canis familiaris)
SYK [cytosol] (Canis familiaris)
Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
FCGR activation (Canis familiaris)
Recruitment of SYK to phosphorylated ITAMs (Canis familiaris)
SYK [cytosol] (Canis familiaris)
clustered IgG-Ag:p-FCGRs:SYK [plasma membrane] (Canis familiaris)
SYK [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Integrin signaling (Canis familiaris)
SYK activation by SRC (Canis familiaris)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
SYK [cytosol] (Canis familiaris)
SYK binds to integrin alphaIIb beta3 (Canis familiaris)
SYK [cytosol] (Canis familiaris)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
SYK [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3P3G0
Gene Names
SYK
Reference Genes
ENSEMBL:ENSCAFG00845018106.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845018106.1 SYK
Reference Transcript
RefSeq:XM_005615953.2 SYK
Other Identifiers
484196
Cfa.18891.1.S1_s_at
CfaAffx.4145.1.S1_at
GO:0000166
GO:0001775
GO:0001784
GO:0001819
GO:0001820
GO:0001945
GO:0002092
GO:0002223
GO:0002281
GO:0002283
GO:0002366
GO:0002376
GO:0002554
GO:0003824
GO:0004672
GO:0004674
GO:0004713
GO:0004715
GO:0005102
GO:0005178
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006468
GO:0006606
GO:0006886
GO:0006913
GO:0006954
GO:0007155
GO:0007159
GO:0007166
GO:0007167
GO:0007229
GO:0010543
GO:0010803
GO:0012501
GO:0016170
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0019370
GO:0019722
GO:0019815
GO:0019901
GO:0019902
GO:0023052
GO:0030154
GO:0030183
GO:0030593
GO:0031334
GO:0031410
GO:0031623
GO:0032009
GO:0032481
GO:0032725
GO:0032733
GO:0032735
GO:0032752
GO:0032753
GO:0032755
GO:0032757
GO:0032760
GO:0032765
GO:0032928
GO:0032930
GO:0032991
GO:0033630
GO:0035325
GO:0035556
GO:0036211
GO:0038063
GO:0038156
GO:0042060
GO:0042101
GO:0042169
GO:0042492
GO:0042742
GO:0043226
GO:0043274
GO:0043303
GO:0043306
GO:0043313
GO:0043366
GO:0043410
GO:0045087
GO:0045579
GO:0045588
GO:0045780
GO:0046638
GO:0046641
GO:0048514
GO:0048856
GO:0048870
GO:0050731
GO:0050764
GO:0050850
GO:0050853
GO:0051649
GO:0051712
GO:0065003
GO:0070372
GO:0071226
GO:0071396
GO:0071404
GO:0071639
GO:0090237
GO:0090330
GO:0097110
GO:0098542
GO:0120162
GO:0140096
GO:1904263
GO:1990858
Participates
as an input of
p-Y7-CLEC1B dimer:PDPN binds SYK (Canis familiaris)
SYK binds to integrin alphaIIb beta3 (Canis familiaris)
Active FLT3 binds to SYK (Canis familiaris)
SYK binds IL2RB (Canis familiaris)
SYK binds to p-Y65,Y76-FCER1G (Canis familiaris)
Recruitment of SYK to p-FCERI gamma subunit (Canis familiaris)
Recruitment of SYK to phosphorylated ITAMs (Canis familiaris)
Recruitment of SYK to p-DAP12 (Canis familiaris)
SYK binds the activated BCR (Canis familiaris)
Binding of Syk tyrosine kinase (Canis familiaris)
as a component of
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
active FLT3:SYK [plasma membrane] (Canis familiaris)
IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Canis familiaris)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] (Canis familiaris)
clustered IgG-Ag:p-FCGRs:SYK [plasma membrane] (Canis familiaris)
Clustered p:LYN:p-FCERI:IgE:allergen:SYK [plasma membrane] (Canis familiaris)
DAP12 receptors:p-DAP12:SYK [plasma membrane] (Canis familiaris)
Antigen:p-BCR:SYK [plasma membrane] (Canis familiaris)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Canis familiaris)
p-Y7-CLEC1B dimer:PDPN:SYK [plasma membrane] (Canis familiaris)
as a candidate of
FYN-like kinases [cytosol] (Canis familiaris)
Other forms of this molecule
phospho-SYK [cytosol]
phospho-SYK [plasma membrane]
phospho-SYK [cytosol]
phospho-SYK [cytosol]
Inferred From
SYK [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_005616010.1
OpenTargets
ENSG00000165025
Ensembl
ENSCAFG00845018106
,
ENSCAFT00845032058
,
ENSCAFP00845025066
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