SYK binds IL2RB

Stable Identifier
R-HSA-508292
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane, extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SYK binds IL2RB
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Syk binds to the serine-rich (aa 267 to 322) S region of IL2RB and becomes activated upon IL-2 stimulation (Minami et al. 1995).
Syk is shown here binding with the IL2:IL2RB trimer:p-JAK1:JAK3 complex but it may become associated at an earlier stage of receptor activation.

Literature References
PubMed ID Title Journal Year
7600304 Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: possible link with the c-myc induction pathway

Taniguchi, T, Minami, Y, Miyazaki, T, Yamamura, H, Sada, K, Kawahara, A, Nakagawa, Y

Immunity 1995
Participants
Input
Output
Participates
as an event of
Orthologous Events
SYK binds IL2RB (Bos taurus)
SYK binds IL2RB (Mus musculus)
SYK binds IL2RB (Sus scrofa)
Authored
Ray, KP  (2010-05-17)
Reviewed
Dooms, H  (2011-03-17)
Villarino, A  (2011-02-11)
Created
Jupe, S  (2010-02-11)
Cite Us!