SYK binds IL2RB

Stable Identifier
R-HSA-508292
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane, extracellular region
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SYK binds IL2RB
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Syk binds to the serine-rich (aa 267 to 322) S region of IL2RB and becomes activated upon IL-2 stimulation (Minami et al. 1995).
Syk is shown here binding with the IL2:IL2RB trimer:p-JAK1:JAK3 complex but it may become associated at an earlier stage of receptor activation.

Literature References
PubMed ID Title Journal Year
7600304 Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: possible link with the c-myc induction pathway

Minami, Y, Nakagawa, Y, Kawahara, A, Miyazaki, T, Sada, K, Yamamura, H, Taniguchi, T

Immunity 1995
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
SYK binds IL2RB (Mus musculus)
SYK binds IL2RB (Rattus norvegicus)
Authored
Ray, KP  (2010-05-17)
Reviewed
Villarino, A  (2011-02-11)
Dooms, H  (2011-03-17)
Created
Jupe, S  (2010-02-11)
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