Syk binds to the serine-rich (aa 267 to 322) S region of IL2RB and becomes activated upon IL-2 stimulation (Minami et al. 1995).Syk is shown here binding with the IL2:IL2RB trimer:p-JAK1:JAK3 complex but it may become associated at an earlier stage of receptor activation.
Minami, Y, Nakagawa, Y, Kawahara, A, Miyazaki, T, Sada, K, Yamamura, H, Taniguchi, T
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