Reactome | Active FLT3 binds to SYK

Active FLT3 binds to SYK

Stable Identifier

R-HSA-9706336

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Spleen-associated tyrosine kinase (SYK) binds to active FLT3 and transactivates it (Puissant et al, 2014).

Literature References

PubMed ID	Title	Journal	Year
24525236	SYK is a critical regulator of FLT3 in acute myeloid leukemia Hemann, MT, Galinsky, I, Luciano, F, Stegmaier, K, Kazi, JU, Kung, AL, Bassil, CF, Mehta, S, Pikman, Y, Fenouille, N, Stone, RM, Alexe, G, Puissant, A, Aster, JC, Deangelo, DJ, Rönnstrand, L, Du, J	Cancer Cell	2014