SYK binds to integrin alphaIIb beta3

Stable Identifier
R-HSA-429415
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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SYK binds to integrin alphaIIb beta3
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Integrin alphaIIb beta3 'outside-in' signalling involves multiple proteins including SRC, SYK, SLP-76 and PLCgamma2. SRC is constitutively associated with the C-terminal tail of integrin beta 3. SYK is recruited to the beta3 tail and subsequently activated by SRC.

Literature References
PubMed ID Title Journal Year
9351824 Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3

Brugge, JS, Ginsberg, MH, Zoller, KE, Gao, J, Shattil, SJ

EMBO J 1997
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Orthologous Events
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Authored
Akkerman, JW  (2009-06-03)
Reviewed
Heemskerk, JW  (2010-09-01)
Created
Jupe, S  (2009-07-15)
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