Recruitment of SYK to p-DAP12

Stable Identifier
R-HSA-210289
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Phosphorylated ITAM on DAP12 serves as the docking site for the two SH2 domains of SYK or ZAP70. Binding leads to SYK activation (Lanier et al. 1998, McVicar et al. 1998).

Literature References
PubMed ID Title Journal Year
9396765 Functional role for Syk tyrosine kinase in natural killer cell-mediated natural cytotoxicity

Brumbaugh, KM, Binstadt, BA, Billadeau, DD, Schoon, RA, Dick, CJ, Ten, RM, Leibson, PJ

J. Exp. Med. 1997
9490415 Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells

Lanier, LL, Corliss, BC, Wu, J, Leong, C, Phillips, JH

Nature 1998
18691974 DAP12 couples c-Fms activation to the osteoclast cytoskeleton by recruitment of Syk

Zou, W, Reeve, JL, Liu, Y, Teitelbaum, SL, Ross, FP

Mol. Cell 2008
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