Reactome | Recruitment of SYK to p-DAP12

Recruitment of SYK to p-DAP12

Stable Identifier

R-HSA-210289

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Phosphorylated ITAM on DAP12 serves as the docking site for the two SH2 domains of SYK or ZAP70. Binding leads to SYK activation (Lanier et al. 1998, McVicar et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
9490415	Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells Lanier, LL, Phillips, JH, Corliss, BC, Leong, C, Wu, J	Nature	1998
9396765	Functional role for Syk tyrosine kinase in natural killer cell-mediated natural cytotoxicity Ten, RM, Dick, CJ, Leibson, PJ, Billadeau, DD, Binstadt, BA, Brumbaugh, KM, Schoon, RA	J. Exp. Med.	1997
18691974	DAP12 couples c-Fms activation to the osteoclast cytoskeleton by recruitment of Syk Liu, Y, Ross, FP, Teitelbaum, SL, Zou, W, Reeve, JL	Mol. Cell	2008