Recruitment of SYK to p-DAP12

Stable Identifier
R-HSA-210289
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Recruitment of SYK to p-DAP12
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Phosphorylated ITAM on DAP12 serves as the docking site for the two SH2 domains of SYK or ZAP70. Binding leads to SYK activation (Lanier et al. 1998, McVicar et al. 1998).
Literature References
PubMed ID Title Journal Year
9490415 Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells

Lanier, LL, Corliss, BC, Wu, J, Leong, C, Phillips, JH

Nature 1998
9396765 Functional role for Syk tyrosine kinase in natural killer cell-mediated natural cytotoxicity

Brumbaugh, KM, Binstadt, BA, Billadeau, DD, Schoon, RA, Dick, CJ, Ten, RM, Leibson, PJ

J. Exp. Med. 1997
18691974 DAP12 couples c-Fms activation to the osteoclast cytoskeleton by recruitment of Syk

Zou, W, Reeve, JL, Liu, Y, Teitelbaum, SL, Ross, FP

Mol. Cell 2008
Participants
Input
Output
Participates
as an event of
Orthologous Events
Recruitment of SYK to p-DAP12 (Canis familiaris)
Recruitment of SYK to p-DAP12 (Mus musculus)
Recruitment of SYK to p-DAP12 (Rattus norvegicus)
Authored
Garapati, P V  (2012-05-25)
Reviewed
Lanier, LL  (2012-08-09)
Created
Garapati, P V  (2008-01-10)
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