CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK

Stable Identifier
R-HSA-9676071
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK
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The kinases JAK2 (Shimoda et al. 1997, Marino and Roguin 2008), TYK2 (Shimoda et al. 1997, Marino and Roguin 2008), HCK, and SYK (Kasper et al. 1999) bind phosphorylated tyrosine residues of the cytosolic domain of CSF3R and are activated by phosphorylation (also inferred from mouse homologs). The order of their binding and the kinases responsible for their phosphorylation are incompletely characterized.
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Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1 binds and activates Jak2, Syk, Hck, and Tyk2 (Mus musculus)
Authored
May, B  (2020-01-29)
Reviewed
Touw, IP  (2020-12-12)
Created
May, B  (2020-02-07)
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