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p-Y188,Y199-CD3E [plasma membrane]
Stable Identifier
R-HSA-202228
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
CD3 epsilon with phosphorylated ITAM
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Costimulation by the CD28 family (Homo sapiens)
PD-1 signaling (Homo sapiens)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Homo sapiens)
Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with dephosphorylated CD3 zeta chain [plasma membrane] (Homo sapiens)
CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Homo sapiens)
p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Homo sapiens)
p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
TCR signaling (Homo sapiens)
Generation of second messenger molecules (Homo sapiens)
Phosphorylation of PLC-gamma1 (Homo sapiens)
ZAP-70 and ITK tyrosine kinases [plasma membrane] (Homo sapiens)
Activated ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Homo sapiens)
p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
Phosphorylation of SLP-76 (Homo sapiens)
Activated ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Homo sapiens)
p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
Phosphorylation of TBSMs in LAT (Homo sapiens)
Activated ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Homo sapiens)
p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
Phosphorylation of CD3 and TCR zeta chains (Homo sapiens)
Phosphorylation of ITAM motifs in CD3 complexes (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Homo sapiens)
p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
Translocation of ZAP-70 to Immunological synapse (Homo sapiens)
Activation of ZAP-70 (Homo sapiens)
Activated ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Homo sapiens)
p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Homo sapiens)
p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
PTPN22 dephosphorylates ZAP70 (Homo sapiens)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Homo sapiens)
p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Homo sapiens)
p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
Phosphorylation of ZAP-70 by Lck (Homo sapiens)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Homo sapiens)
p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Homo sapiens)
p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
Recruitment of ZAP-70 to phosphorylated ITAMs (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Homo sapiens)
p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Homo sapiens)
p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07766 CD3E
Gene Names
CD3E, T3E
Chain
signal peptide:1-22, chain:23-207
Reference Genes
BioGPS Gene:916 CD3E
COSMIC (genes):CD3E CD3E
CTD Gene:916 CD3E
dbSNP Gene:916 CD3E
ENSEMBL:ENSG00000198851 CD3E
HGNC:1674 CD3E
KEGG Gene (Homo sapiens):916 CD3E
Monarch:916 CD3E
NCBI Gene:916 CD3E
OMIM:186830 CD3E
UCSC:P07766 CD3E
Reference Transcript
RefSeq:NM_000733.3 CD3E
Other Identifiers
11729855_at
16731795
205456_at
3351284
3351286
3351287
3351289
3351292
3351294
3351296
3351297
36277_at
7944179
916
A_14_P117535
A_23_P416747
A_24_P86968
GE60506
GO:0001772
GO:0001954
GO:0002250
GO:0002376
GO:0002669
GO:0003674
GO:0004888
GO:0005515
GO:0005575
GO:0005886
GO:0005887
GO:0005911
GO:0006464
GO:0007155
GO:0007165
GO:0007166
GO:0007169
GO:0007172
GO:0007186
GO:0007584
GO:0008150
GO:0008219
GO:0008283
GO:0009897
GO:0010628
GO:0010629
GO:0016020
GO:0016021
GO:0016358
GO:0017124
GO:0019899
GO:0019901
GO:0021549
GO:0022607
GO:0030154
GO:0030159
GO:0030217
GO:0030674
GO:0031295
GO:0032729
GO:0032743
GO:0032753
GO:0032991
GO:0033077
GO:0033634
GO:0042101
GO:0042102
GO:0042105
GO:0042110
GO:0042608
GO:0042802
GO:0042981
GO:0043197
GO:0044297
GO:0045059
GO:0045060
GO:0045879
GO:0046641
GO:0046649
GO:0046982
GO:0048856
GO:0050731
GO:0050776
GO:0050850
GO:0050852
GO:0050870
GO:0065003
GO:0097190
ILMN_1739794
M23323_s_at
PH_hs_0000378
TC11001060.hg
g4502670_3p_at
Participant Of
hasComponent
CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane]
CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane]
Other forms of this molecule
CD3E [plasma membrane]
Inferred To
phospho-CD3E [plasma membrane] (Canis familiaris)
phospho-p-Y188,Y199-CD3E [plasma membrane] (Xenopus tropicalis)
phospho-Cd3e [plasma membrane] (Mus musculus)
phospho-Cd3e [plasma membrane] (Rattus norvegicus)
Ghost homologue of p-Y188,Y199-CD3E [plasma membrane] (Gallus gallus)
Ghost homologue of p-Y188,Y199-CD3E [plasma membrane] (Sus scrofa)
Modified Residues
Name
O4'-phospho-L-tyrosine at 188
Coordinate
188
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 199
Coordinate
199
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_000724.1
OpenTargets
ENSG00000198851
GeneCards
P07766
HPA
ENSG00000198851-CD3E
Ensembl
ENSP00000354566
,
ENSG00000198851
,
ENST00000361763
PRO
P07766
Orphanet
17286
PDB
6JXR
,
1SY6
,
1A81
,
1XIW
,
2ROL
,
5QU2
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P16333 NCK1
2
NCK1 [cytosol]
(R-HSA-197954)
NCK1 [plasma membrane]
(R-HSA-202992)
0.737
6
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.675
4
UniProt:P43405 SYK
6
SYK [plasma membrane]
(R-HSA-139844)
p-Y-SYK [plasma membrane]
(R-HSA-429432)
p-6Y-SYK [cytosol]
(R-HSA-983586)
p-Y348-SYK [cytosol]
(R-HSA-437953)
SYK [cytosol]
(R-HSA-58268)
p-6Y-SYK [cytosol]
(R-HSA-1861712)
0.597
6
UniProt:P43403 ZAP70
3
p-Y493-ZAP70 [cytosol]
(R-HSA-202368)
ZAP70 [cytosol]
(R-HSA-202397)
p-Y315,Y493-ZAP70 [cytosol]
(R-HSA-202252)
0.527
3
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