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SYK [cytosol]
Stable Identifier
R-BTA-58268
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
A0A3Q1MHG9
Locations in the PathwayBrowser
Expand all
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
GPVI-mediated activation cascade (Bos taurus)
Binding of Syk tyrosine kinase (Bos taurus)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Bos taurus)
SYK [cytosol] (Bos taurus)
SYK [cytosol] (Bos taurus)
GPVI stimulates PI3K beta, gamma (Bos taurus)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Bos taurus)
SYK [cytosol] (Bos taurus)
PLC gamma 2-mediated PIP2 hydrolysis (Bos taurus)
p-Y7-CLEC1B dimer:PDPN:SYK [plasma membrane] (Bos taurus)
SYK [cytosol] (Bos taurus)
SYK autophosphorylates (Bos taurus)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Bos taurus)
SYK [cytosol] (Bos taurus)
SYK [cytosol] (Bos taurus)
p-Y7-CLEC1B dimer:PDPN binds SYK (Bos taurus)
SYK [cytosol] (Bos taurus)
p-Y7-CLEC1B dimer:PDPN:SYK [plasma membrane] (Bos taurus)
SYK [cytosol] (Bos taurus)
Platelet Aggregation (Plug Formation) (Bos taurus)
Integrin signaling (Bos taurus)
SYK activation by SRC (Bos taurus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
SYK [cytosol] (Bos taurus)
SYK binds to integrin alphaIIb beta3 (Bos taurus)
SYK [cytosol] (Bos taurus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
SYK [cytosol] (Bos taurus)
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Signaling by the B Cell Receptor (BCR) (Bos taurus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Bos taurus)
SYK autophosphorylates at the activated BCR (Bos taurus)
Antigen:p-BCR:SYK [plasma membrane] (Bos taurus)
SYK [cytosol] (Bos taurus)
SYK binds the activated BCR (Bos taurus)
Antigen:p-BCR:SYK [plasma membrane] (Bos taurus)
SYK [cytosol] (Bos taurus)
SYK [cytosol] (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
FLT3 Signaling (Bos taurus)
FLT3 signaling through SRC family kinases (Bos taurus)
Active FLT3 binds to SYK (Bos taurus)
SYK [cytosol] (Bos taurus)
active FLT3:SYK [plasma membrane] (Bos taurus)
SYK [cytosol] (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-2 family signaling (Bos taurus)
Interleukin-2 signaling (Bos taurus)
SYK binds IL2RB (Bos taurus)
IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Bos taurus)
SYK [cytosol] (Bos taurus)
SYK [cytosol] (Bos taurus)
SYK is a substrate for JAK1 (Bos taurus)
IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Bos taurus)
SYK [cytosol] (Bos taurus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Bos taurus)
Regulation of signaling by CBL (Bos taurus)
CBL ubiquitinates PI3K (Bos taurus)
FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
FYN-like kinases [cytosol] (Bos taurus)
SYK [cytosol] (Bos taurus)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
FYN-like kinases [cytosol] (Bos taurus)
SYK [cytosol] (Bos taurus)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Bos taurus)
FYN-like kinases [cytosol] (Bos taurus)
SYK [cytosol] (Bos taurus)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
FYN-like kinases [cytosol] (Bos taurus)
SYK [cytosol] (Bos taurus)
Innate Immune System (Bos taurus)
C-type lectin receptors (CLRs) (Bos taurus)
Dectin-2 family (Bos taurus)
SYK autophosphorylates (Bos taurus)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] (Bos taurus)
SYK [cytosol] (Bos taurus)
SYK binds to p-Y65,Y76-FCER1G (Bos taurus)
SYK [cytosol] (Bos taurus)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] (Bos taurus)
SYK [cytosol] (Bos taurus)
Fc epsilon receptor (FCERI) signaling (Bos taurus)
Recruitment of SYK to p-FCERI gamma subunit (Bos taurus)
Clustered p:LYN:p-FCERI:IgE:allergen:SYK [plasma membrane] (Bos taurus)
SYK [cytosol] (Bos taurus)
SYK [cytosol] (Bos taurus)
Fcgamma receptor (FCGR) dependent phagocytosis (Bos taurus)
FCGR activation (Bos taurus)
Recruitment of SYK to phosphorylated ITAMs (Bos taurus)
SYK [cytosol] (Bos taurus)
clustered IgG-Ag:p-FCGRs:SYK [plasma membrane] (Bos taurus)
SYK [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Integrin signaling (Bos taurus)
SYK activation by SRC (Bos taurus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
SYK [cytosol] (Bos taurus)
SYK binds to integrin alphaIIb beta3 (Bos taurus)
SYK [cytosol] (Bos taurus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
SYK [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:A0A3Q1MHG9
Reference Genes
BioGPS Gene:515515
ENSEMBL:ENSBTAG00000004767.6
ENSEMBL:ENSBTAG00000004767.7
Monarch:515515
NCBI Gene:515515
Reference Transcript
RefSeq:XM_010808169.2
RefSeq:XM_005210435.3
Other Identifiers
515515
GO:0001775
GO:0001784
GO:0001819
GO:0001820
GO:0001945
GO:0002092
GO:0002223
GO:0002281
GO:0002283
GO:0002366
GO:0002376
GO:0002554
GO:0003824
GO:0004672
GO:0004674
GO:0004713
GO:0004715
GO:0005102
GO:0005178
GO:0005524
GO:0005634
GO:0005737
GO:0005886
GO:0006606
GO:0006886
GO:0006913
GO:0006954
GO:0007155
GO:0007159
GO:0007166
GO:0007167
GO:0007229
GO:0010543
GO:0010803
GO:0012501
GO:0016170
GO:0016192
GO:0016301
GO:0016740
GO:0019370
GO:0019722
GO:0019815
GO:0019901
GO:0019902
GO:0023052
GO:0030154
GO:0030183
GO:0030593
GO:0031334
GO:0031410
GO:0031623
GO:0032009
GO:0032481
GO:0032725
GO:0032733
GO:0032735
GO:0032752
GO:0032753
GO:0032755
GO:0032757
GO:0032760
GO:0032765
GO:0032928
GO:0032930
GO:0032991
GO:0033630
GO:0035325
GO:0035556
GO:0036211
GO:0038063
GO:0038156
GO:0042060
GO:0042101
GO:0042169
GO:0042492
GO:0042742
GO:0043226
GO:0043274
GO:0043303
GO:0043306
GO:0043313
GO:0043366
GO:0043410
GO:0045087
GO:0045579
GO:0045588
GO:0045780
GO:0046638
GO:0046641
GO:0048514
GO:0048856
GO:0048870
GO:0050731
GO:0050764
GO:0050850
GO:0050853
GO:0051649
GO:0051712
GO:0065003
GO:0070372
GO:0071226
GO:0071396
GO:0071404
GO:0071639
GO:0090237
GO:0090330
GO:0097110
GO:0098542
GO:0120162
GO:0140096
GO:1904263
GO:1990858
Participates
as an input of
p-Y7-CLEC1B dimer:PDPN binds SYK (Bos taurus)
SYK binds to integrin alphaIIb beta3 (Bos taurus)
Active FLT3 binds to SYK (Bos taurus)
SYK binds to p-Y65,Y76-FCER1G (Bos taurus)
SYK binds IL2RB (Bos taurus)
Recruitment of SYK to p-FCERI gamma subunit (Bos taurus)
Recruitment of SYK to phosphorylated ITAMs (Bos taurus)
SYK binds the activated BCR (Bos taurus)
Binding of Syk tyrosine kinase (Bos taurus)
as a component of
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
active FLT3:SYK [plasma membrane] (Bos taurus)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] (Bos taurus)
IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Bos taurus)
clustered IgG-Ag:p-FCGRs:SYK [plasma membrane] (Bos taurus)
Clustered p:LYN:p-FCERI:IgE:allergen:SYK [plasma membrane] (Bos taurus)
Antigen:p-BCR:SYK [plasma membrane] (Bos taurus)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Bos taurus)
p-Y7-CLEC1B dimer:PDPN:SYK [plasma membrane] (Bos taurus)
as a candidate of
FYN-like kinases [cytosol] (Bos taurus)
Other forms of this molecule
phospho-p-Y-SYK [cytosol]
phospho-p-Y-SYK [plasma membrane]
phospho-p-6Y-SYK [cytosol]
phospho-p-Y348-SYK [cytosol]
Inferred From
SYK [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_010806471.1
,
XP_005210492.1
Ensembl
ENSBTAP00000006260
,
ENSBTAG00000004767
,
ENSBTAT00000006260
VGNC
35513
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