Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
SYK [cytosol]
Stable Identifier
R-GGA-58268
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
F1N9Y5
Locations in the PathwayBrowser
Expand all
Hemostasis (Gallus gallus)
Platelet activation, signaling and aggregation (Gallus gallus)
Platelet Aggregation (Plug Formation) (Gallus gallus)
Integrin signaling (Gallus gallus)
SYK activation by SRC (Gallus gallus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Gallus gallus)
SYK [cytosol] (Gallus gallus)
SYK binds to integrin alphaIIb beta3 (Gallus gallus)
SYK [cytosol] (Gallus gallus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Gallus gallus)
SYK [cytosol] (Gallus gallus)
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
Signaling by the B Cell Receptor (BCR) (Gallus gallus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Gallus gallus)
SYK autophosphorylates at the activated BCR (Gallus gallus)
Antigen:p-BCR:SYK [plasma membrane] (Gallus gallus)
SYK [cytosol] (Gallus gallus)
SYK binds the activated BCR (Gallus gallus)
Antigen:p-BCR:SYK [plasma membrane] (Gallus gallus)
SYK [cytosol] (Gallus gallus)
SYK [cytosol] (Gallus gallus)
Cytokine Signaling in Immune system (Gallus gallus)
Signaling by Interleukins (Gallus gallus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Gallus gallus)
Regulation of signaling by CBL (Gallus gallus)
CBL ubiquitinates PI3K (Gallus gallus)
FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Gallus gallus)
FYN-like kinases [cytosol] (Gallus gallus)
SYK [cytosol] (Gallus gallus)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Gallus gallus)
FYN-like kinases [cytosol] (Gallus gallus)
SYK [cytosol] (Gallus gallus)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Gallus gallus)
FYN-like kinases [cytosol] (Gallus gallus)
SYK [cytosol] (Gallus gallus)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Gallus gallus)
FYN-like kinases [cytosol] (Gallus gallus)
SYK [cytosol] (Gallus gallus)
Innate Immune System (Gallus gallus)
DAP12 interactions (Gallus gallus)
DAP12 signaling (Gallus gallus)
Phosphorylation of SYK (Gallus gallus)
DAP12 receptors:p-DAP12:SYK [plasma membrane] (Gallus gallus)
SYK [cytosol] (Gallus gallus)
SYK [cytosol] (Gallus gallus)
Recruitment of SYK to p-DAP12 (Gallus gallus)
DAP12 receptors:p-DAP12:SYK [plasma membrane] (Gallus gallus)
SYK [cytosol] (Gallus gallus)
SYK [cytosol] (Gallus gallus)
Fcgamma receptor (FCGR) dependent phagocytosis (Gallus gallus)
FCGR activation (Gallus gallus)
Recruitment of SYK to phosphorylated ITAMs (Gallus gallus)
SYK [cytosol] (Gallus gallus)
clustered IgG-Ag:p-FCGRs:SYK [plasma membrane] (Gallus gallus)
SYK [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Integrin signaling (Gallus gallus)
SYK activation by SRC (Gallus gallus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Gallus gallus)
SYK [cytosol] (Gallus gallus)
SYK binds to integrin alphaIIb beta3 (Gallus gallus)
SYK [cytosol] (Gallus gallus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Gallus gallus)
SYK [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:F1N9Y5 SYK
Gene Names
SYK, RCJMB04_19o18
Chain
chain:1-613
Reference Genes
BioGPS Gene:427272 SYK
ENSEMBL:ENSGALG00000015216 SYK
ENSEMBL:ENSGALG00010009340.1 SYK
ENSEMBL:ENSGALG00015028988 SYK
KEGG Gene (Gallus gallus):427272 SYK
Monarch:427272 SYK
NCBI Gene:427272 SYK
Reference Transcript
RefSeq:NM_001031430.1 SYK
Other Identifiers
427272
GO:0000166
GO:0001945
GO:0002250
GO:0002281
GO:0002283
GO:0002366
GO:0002376
GO:0002554
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0005102
GO:0005515
GO:0005524
GO:0005737
GO:0005829
GO:0005886
GO:0006468
GO:0006954
GO:0007155
GO:0007159
GO:0007169
GO:0007229
GO:0010543
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0023052
GO:0030154
GO:0030593
GO:0031234
GO:0031410
GO:0032009
GO:0032928
GO:0033630
GO:0035556
GO:0036211
GO:0042060
GO:0042742
GO:0043226
GO:0043306
GO:0043313
GO:0045087
GO:0045579
GO:0045780
GO:0046641
GO:0048514
GO:0048856
GO:0048870
GO:0050764
GO:0050853
GO:0070301
GO:0070372
GO:0071226
GO:0090237
GO:0090330
GO:0098542
GO:0140096
GT_A_87_P092781
GgaAffx.12646.1.S1_at
GgaAffx.9684.1.S1_s_at
Participates
as an input of
SYK binds to integrin alphaIIb beta3 (Gallus gallus)
Recruitment of SYK to phosphorylated ITAMs (Gallus gallus)
Recruitment of SYK to p-DAP12 (Gallus gallus)
SYK binds the activated BCR (Gallus gallus)
as a component of
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Gallus gallus)
clustered IgG-Ag:p-FCGRs:SYK [plasma membrane] (Gallus gallus)
DAP12 receptors:p-DAP12:SYK [plasma membrane] (Gallus gallus)
Antigen:p-BCR:SYK [plasma membrane] (Gallus gallus)
as a candidate of
FYN-like kinases [cytosol] (Gallus gallus)
Other forms of this molecule
phospho-p-Y-SYK [cytosol]
phospho-p-Y-SYK [plasma membrane]
SYK [plasma membrane]
phospho-p-6Y-SYK [cytosol]
phospho-p-Y348-SYK [cytosol]
Inferred From
SYK [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001026601.1
OpenTargets
ENSG00000165025
Ensembl
ENSGALP00010012784
,
ENSGALG00010009340
,
ENSGALT00010022248
PRO
F1N9Y5
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text