SYK is a cytoplasmic tyrosine kinase related to ZAP70 that is expressed in all hematopoietic cells and coimmunoprecipitates with the gamma chain associated with FCGRIIIA in macrophages and with FCERI in mast cells. Tyrosine phosphorylation of the FCER1G ITAM recruits SYK and initiates a signaling cascade, leading to the activation of transcription factors such as NF-kB via CARD9-BCL10-MALT1 (Kerscher et al. 2013).
Yamasaki, S, Ishikawa, E, Sakuma, M, Hara, H, Ogata, K, Saito, T
Sato, K, Yang, XL, Yudate, T, Chung, JS, Wu, J, Luby-Phelps, K, Kimberly, RP, Underhill, D, Cruz, PD, Ariizumi, K
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