SYK binds to p-Y65,Y76-FCER1G

Stable Identifier
R-HSA-5621366
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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SYK is a cytoplasmic tyrosine kinase related to ZAP70 that is expressed in all hematopoietic cells and coimmunoprecipitates with the gamma chain associated with FCGRIIIA in macrophages and with FCERI in mast cells. Tyrosine phosphorylation of the FCER1G ITAM recruits SYK and initiates a signaling cascade, leading to the activation of transcription factors such as NF-kB via CARD9-BCL10-MALT1 (Kerscher et al. 2013).

Literature References
PubMed ID Title Journal Year
18776906 Mincle is an ITAM-coupled activating receptor that senses damaged cells

Yamasaki, S, Ishikawa, E, Sakuma, M, Hara, H, Ogata, K, Saito, T

Nat. Immunol. 2008
17050534 Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor gamma chain to induce innate immune responses

Sato, K, Yang, XL, Yudate, T, Chung, JS, Wu, J, Luby-Phelps, K, Kimberly, RP, Underhill, D, Cruz, PD, Ariizumi, K

J. Biol. Chem. 2006
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