Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
PYCARD [cytosol]
Stable Identifier
R-HSA-561191
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
ASC, Apoptosis-associated speck-like protein containing a CARD, ASC_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Leishmania infection (Homo sapiens)
Cell recruitment (pro-inflammatory response) (Homo sapiens)
Purinergic signaling in leishmaniasis infection (Homo sapiens)
NLRP3 recruits PYCARD (ASC) via a PYD-PYD interaction (Homo sapiens)
NLRP3 elicitors:NLRP3 oligomer:ASC [cytosol] (Homo sapiens)
PYCARD [cytosol] (Homo sapiens)
PYCARD [cytosol] (Homo sapiens)
PYCARD recruits procaspase-1 via CARD (Homo sapiens)
NLRP3 elicitors:NLRP3 oligomer:ASC [cytosol] (Homo sapiens)
PYCARD [cytosol] (Homo sapiens)
NLRP3 elicitors:NLRP3 oligomer:ASC:Procaspase-1 [cytosol] (Homo sapiens)
NLRP3 elicitors:NLRP3 oligomer:ASC [cytosol] (Homo sapiens)
PYCARD [cytosol] (Homo sapiens)
Pyrin binds ASC (Homo sapiens)
PYCARD [cytosol] (Homo sapiens)
Pyrin trimer:ASC [cytosol] (Homo sapiens)
PYCARD [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
CLEC7A/inflammasome pathway (Homo sapiens)
ASC binds Caspase-8 complex (Homo sapiens)
MALT1 oligomers:active caspase-8:ASC [cytosol] (Homo sapiens)
PYCARD [cytosol] (Homo sapiens)
PYCARD [cytosol] (Homo sapiens)
Caspase-8 cleaves IL1B precursor (Homo sapiens)
MALT1 oligomers:active caspase-8:ASC [cytosol] (Homo sapiens)
PYCARD [cytosol] (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
Inflammasomes (Homo sapiens)
The AIM2 inflammasome (Homo sapiens)
dsDNA:AIM2 clusters bind ASC (Homo sapiens)
PYCARD [cytosol] (Homo sapiens)
dsDNA:AIM2 oligomer:ASC [cytosol] (Homo sapiens)
PYCARD [cytosol] (Homo sapiens)
dsDNA:AIM2:ASC cluster binds procaspase-1 (Homo sapiens)
dsDNA:AIM2 oligomer:ASC [cytosol] (Homo sapiens)
PYCARD [cytosol] (Homo sapiens)
dsDNA:AIM2 oligomer:ASC:Procaspase-1 [cytosol] (Homo sapiens)
dsDNA:AIM2 oligomer:ASC [cytosol] (Homo sapiens)
PYCARD [cytosol] (Homo sapiens)
The NLRP3 inflammasome (Homo sapiens)
NLRP3 recruits PYCARD (ASC) via a PYD-PYD interaction (Homo sapiens)
NLRP3 elicitors:NLRP3 oligomer:ASC [cytosol] (Homo sapiens)
PYCARD [cytosol] (Homo sapiens)
PYCARD [cytosol] (Homo sapiens)
PYCARD recruits procaspase-1 via CARD (Homo sapiens)
NLRP3 elicitors:NLRP3 oligomer:ASC [cytosol] (Homo sapiens)
PYCARD [cytosol] (Homo sapiens)
NLRP3 elicitors:NLRP3 oligomer:ASC:Procaspase-1 [cytosol] (Homo sapiens)
NLRP3 elicitors:NLRP3 oligomer:ASC [cytosol] (Homo sapiens)
PYCARD [cytosol] (Homo sapiens)
Pyrin binds ASC (Homo sapiens)
PYCARD [cytosol] (Homo sapiens)
Pyrin trimer:ASC [cytosol] (Homo sapiens)
PYCARD [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9ULZ3 PYCARD
Gene Names
PYCARD, ASC, CARD5, TMS1
Chain
chain:1-195
Reference Genes
BioGPS Gene:29108 PYCARD
COSMIC (genes):PYCARD PYCARD
CTD Gene:29108 PYCARD
dbSNP Gene:29108 PYCARD
ENSEMBL:ENSG00000103490 PYCARD
HGNC:16608 PYCARD
KEGG Gene (Homo sapiens):29108 PYCARD
Monarch:29108 PYCARD
NCBI Gene:29108 PYCARD
OMIM:606838 PYCARD
UCSC:Q9ULZ3 PYCARD
Reference Transcript
RefSeq:NM_145182.2 PYCARD
RefSeq:NM_013258.4 PYCARD
Other Identifiers
0000050195
11721169_a_at
11750531_a_at
16825997
221666_PM_s_at
221666_s_at
29108
3688312
3688313
3688314
3688315
3688317
3688318
3688319
3688320
46664_at
8001030
A_23_P26629
GE58507
GO:0000139
GO:0001773
GO:0002020
GO:0002218
GO:0002221
GO:0002230
GO:0002277
GO:0002376
GO:0002588
GO:0002821
GO:0003674
GO:0004197
GO:0005138
GO:0005515
GO:0005523
GO:0005575
GO:0005576
GO:0005622
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005739
GO:0005764
GO:0005773
GO:0005783
GO:0005794
GO:0005829
GO:0005856
GO:0005874
GO:0006464
GO:0006508
GO:0006810
GO:0006914
GO:0006915
GO:0006919
GO:0006950
GO:0006954
GO:0007005
GO:0007010
GO:0007155
GO:0007165
GO:0007231
GO:0008092
GO:0008150
GO:0008219
GO:0008233
GO:0008283
GO:0008385
GO:0008656
GO:0009056
GO:0009058
GO:0009617
GO:0010506
GO:0010803
GO:0016020
GO:0016192
GO:0017024
GO:0019899
GO:0022607
GO:0030234
GO:0030838
GO:0031410
GO:0031647
GO:0032088
GO:0032090
GO:0032688
GO:0032722
GO:0032729
GO:0032731
GO:0032733
GO:0032755
GO:0032757
GO:0032760
GO:0032991
GO:0033209
GO:0034641
GO:0034774
GO:0035578
GO:0040011
GO:0042104
GO:0042771
GO:0042802
GO:0042803
GO:0042981
GO:0043025
GO:0043065
GO:0043087
GO:0043124
GO:0043226
GO:0043280
GO:0043281
GO:0044281
GO:0044325
GO:0044351
GO:0045087
GO:0046330
GO:0046456
GO:0046983
GO:0048870
GO:0050727
GO:0050729
GO:0050766
GO:0050829
GO:0050830
GO:0050870
GO:0051091
GO:0051092
GO:0051260
GO:0051604
GO:0051607
GO:0061702
GO:0065003
GO:0070269
GO:0070374
GO:0070700
GO:0071222
GO:0071347
GO:0071356
GO:0071901
GO:0072332
GO:0072558
GO:0072559
GO:0090200
GO:0097153
GO:0097169
GO:0097202
GO:1900016
GO:2000406
GO:2001056
GO:2001238
GO:2001242
HMNXSV003043000
ILMN_1698766
ILMN_2398274
PH_hs_0022963
TC16001052.hg
g13325315_3p_a_at
Participates
as a component of
MALT1 oligomers:active caspase-8:ASC [cytosol] (Homo sapiens)
dsDNA:AIM2 oligomer:ASC [cytosol] (Homo sapiens)
Pyrin trimer:ASC [cytosol] (Homo sapiens)
NLRP3 elicitors:NLRP3 oligomer:ASC [cytosol] (Homo sapiens)
as an input of
ASC binds Caspase-8 complex (Homo sapiens)
dsDNA:AIM2 clusters bind ASC (Homo sapiens)
Pyrin binds ASC (Homo sapiens)
NLRP3 recruits PYCARD (ASC) via a PYD-PYD interaction (Homo sapiens)
Other forms of this molecule
PYCARD [secretory granule lumen]
PYCARD [extracellular region]
PYCARD [azurophil granule lumen]
Inferred To
Pycard [cytosol]
(Mus musculus)
Pycard [cytosol]
(Rattus norvegicus)
PYCARD [cytosol]
(Bos taurus)
PYCARD [cytosol]
(Canis familiaris)
CARD8 [cytosol]
(Gallus gallus)
pycard [cytosol]
(Danio rerio)
ASC [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_660183.1
,
NP_037390.2
OpenTargets
ENSG00000103490
HPA
ENSG00000103490-PYCARD
GeneCards
Q9ULZ3
Ensembl
ENST00000350605
,
ENSP00000340441
,
ENST00000247470
,
ENSP00000247470
,
ENSG00000103490
PRO
Q9ULZ3
Pharos - Targets
Q9ULZ3
Orphanet
27133
HMDB Protein
HMDBP13951
PDB
6N1H
,
3J63
,
7KEU
,
5H8O
,
6K99
,
6KI0
,
2KN6
,
1UCP
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96P20 NLRP3
2
K63polyUb-NLRP3 [cytosol]
(R-HSA-6783288)
NLRP3 [cytosol]
(R-HSA-561189)
0.917
24
UniProt:O14862 AIM2
1
AIM2 [cytosol]
(R-HSA-874111)
0.892
13
UniProt:O15553 MEFV
1
MEFV [cytosol]
(R-HSA-877355)
0.796
10
UniProt:Q9ULZ3 PYCARD
4
PYCARD [cytosol]
(R-HSA-561191)
PYCARD [secretory granule lumen]
(R-HSA-6800957)
PYCARD [extracellular region]
(R-HSA-6806196)
PYCARD [azurophil granule lumen]
(R-HSA-6798768)
0.789
8
UniProt:P29466 CASP1
5
CASP1(1-119) [cytosol]
(R-HSA-448680)
CASP1(298-316) [cytosol]
(R-HSA-448674)
CASP1(120-297) [cytosol]
(R-HSA-448686)
CASP1(317-404) [cytosol]
(R-HSA-448704)
CASP1(1-404) [cytosol]
(R-HSA-448692)
0.765
9
UniProt:Q07812 BAX
3
BAX [cytosol]
(R-HSA-139916)
BAX activated [cytosol]
(R-HSA-139907)
BAX [mitochondrial outer membrane]
(R-HSA-139949)
0.619
7
UniProt:Q56P42 PYDC2
0.602
4
UniProt:P43405 SYK
6
p-Y-SYK [cytosol]
(R-HSA-9705732)
p-Y-SYK [plasma membrane]
(R-HSA-429432)
SYK [plasma membrane]
(R-HSA-139844)
p-6Y-SYK [cytosol]
(R-HSA-1861712)
p-Y348-SYK [cytosol]
(R-HSA-437953)
SYK [cytosol]
(R-HSA-58268)
0.591
4
UniProt:Q9C000 NLRP1
1
NLRP1 [cytosol]
(R-HSA-561196)
0.558
5
UniProt:O00471 EXOC5
2
EXOC5 [cytosol]
(R-HSA-265045)
EXOC5 [cytosol]
(R-HSA-5623383)
0.556
5
UniProt:Q7RTR2 NLRC3
1
NLRC3 [cytosol]
(R-HSA-561197)
0.556
3
UniProt:Q9NPP4 NLRC4
1
NLRC4 [cytosol]
(R-HSA-561198)
0.547
2
UniProt:O15111 CHUK
3
CHUK [cytosol]
(R-HSA-168104)
p-S176,S180-CHUK [cytosol]
(R-HSA-177667)
p-T23-CHUK [cytosol]
(R-HSA-198615)
0.512
5
UniProt:O14920 IKBKB
3
IKBKB [cytosol]
(R-HSA-168114)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
0.512
4
UniProt:Q8WXC3 PYDC1
0.463
2
© 2022
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text