Reactome | Transport of SEC22B, TAP and PLC from ER to ERGIC

Transport of SEC22B, TAP and PLC from ER to ERGIC

Stable Identifier

R-HSA-8863914

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum-Golgi intermediate compartment membrane, endoplasmic reticulum membrane, integral component of lumenal side of endoplasmic reticulum membrane

ReviewStatus

5/5

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Transport of SEC22B, TAP and PLC from ER to ERGIC

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In DCs subset of ER proteins including MHC-I peptide loading complex (PLC) and transporter associated with antigen processing (TAP) transit to phagosomes via the intermediate compartment ER-Golgi intermediate compartment (ERGIC) (Cebrian et al. 2011). TAP exits the ER in COPII vesicles in association with MHC class I, and that peptide translocation by TAP and binding to class I can occur in post-ER compartments (Ghanem et al. 2010). SEC22B, an ER-resident SNARE is required for the transport of PLC from ERGIC (Cebrian et al. 2011), but this step does not deliver MHC-I (Nair-Gupta et al. 2014). Instead, MHC-I are recruited from an endosomal recycling compartment (ERC), which is marked by Rab11a, VAMP3/cellubrevin, and VAMP8/endobrevin that holds large reserves of MHC-I. This step is dependent on TLR signalling (Nair-Gupta et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
22153078	Sec22b regulates phagosomal maturation and antigen crosspresentation by dendritic cells Savina, A, Amigorena, S, Blanchard, N, Moita, LF, Moita, C, Visentin, G, Jouve, M, Bobard, A, Cebrian, I, Enninga, J	Cell	2011
25083866	TLR signals induce phagosomal MHC-I delivery from the endosomal recycling compartment to allow cross-presentation Tampé, R, Whiteheart, SW, Florey, O, Blander, JM, Huang, Y, Baccarini, A, Amsen, D, Overholtzer, M, Brown, BD, Seyffer, F, Tung, N, Nair-Gupta, P, Roche, PA, Banerjee, M	Cell	2014