Reactome | HSD17B11 [cytosol]

HSD17B11 [cytosol]

Stable Identifier

R-HSA-5693370

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Estradiol 17-beta-dehydrogenase 11 ecNumber1.1.1.62/ecNumber, DHB11_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8NBQ5 HSD17B11

Gene Names

HSD17B11, DHRS8, PAN1B, SDR16C2, PSEC0029, UNQ207/PRO233

Chain

signal peptide:1-19, chain:20-300

Reference Genes

BioGPS Gene:51170 HSD17B11

COSMIC (genes):HSD17B11 HSD17B11

CTD Gene:51170 HSD17B11

dbSNP Gene:51170 HSD17B11

ENSEMBL:ENSG00000198189 HSD17B11

HGNC:22960 HSD17B11

KEGG Gene (Homo sapiens):51170 HSD17B11

Monarch:51170 HSD17B11

NCBI Gene:51170 HSD17B11

OMIM:612831 HSD17B11

UCSC:Q8NBQ5 HSD17B11

Reference Transcript

RefSeq:NM_016245.4 HSD17B11

Other Identifiers

0006400452

11730778_a_at

11757494_s_at

16977820

217989_at

2777071

2777072

2777073

2777074

2777075

2777078

2777085

2777086

2777088

2777091

2777100

2777101

51170

53719_at

8101648

A_23_P21644

A_23_P408271

GE58711

GO:0003674

GO:0004303

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005783

GO:0005811

GO:0005829

GO:0006629

GO:0006694

GO:0006703

GO:0006710

GO:0008150

GO:0009056

GO:0009058

GO:0016229

GO:0016491

GO:0016616

GO:0043226

GO:0055114

ILMN_1675117

ILMN_1722076

ILMN_1735367

PH_hs_0023459

TC04002945.hg

g7705904_3p_at

Inferred To

Dmel\CG17121 [cytosol] (Drosophila melanogaster)

HSD17B11 [cytosol] (Bos taurus)

HSD17B11 [cytosol] (Gallus gallus)

HSD17B11 [cytosol] (Saccharomyces cerevisiae)

TDA5 [cytosol] (Saccharomyces cerevisiae)

firl [cytosol] (Drosophila melanogaster)

dhs-4 [cytosol] (Caenorhabditis elegans)

Dmel\CG15629 [cytosol] (Drosophila melanogaster)

Hsd17b11 [cytosol] (Mus musculus)

Hsd17b11 [cytosol] (Rattus norvegicus)

dhs-29 [cytosol] (Caenorhabditis elegans)

dhs-3 [cytosol] (Caenorhabditis elegans)

Dmel\CG13833 [cytosol] (Drosophila melanogaster)

hsd17b11 [cytosol] (Xenopus tropicalis)

Dmel\CG9265 [cytosol] (Drosophila melanogaster)

Ldsdh1 [cytosol] (Drosophila melanogaster)

Homologues of HSD17B11 [cytosol] (Caenorhabditis elegans)

Homologues of HSD17B11 [cytosol] (Drosophila melanogaster)

Homologues of HSD17B11 [cytosol] (Saccharomyces cerevisiae)

dhs-19 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_057329.3

OpenTargets

ENSG00000198189

HPA

ENSG00000198189-HSD17B11

GeneCards

Q8NBQ5

Ensembl

ENSP00000351035, ENST00000358290, ENSG00000198189

PRO

Q8NBQ5

PDB

1YB1

HMDB Protein

HMDBP00547

Interactors (60)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6ZPD8 DGAT2L6	1	DGAT2L6 [endoplasmic reticulum membrane] (R-HSA-8848588)	0.556	3
UniProt:Q99519 NEU1	8	NEU1 W29* [lysosomal lumen] (R-HSA-5674174) NEU1 W23* [lysosomal lumen] (R-HSA-5674155) NEU1 E377* [lysosomal lumen] (R-HSA-5674181) NEU1 R225P [lysosomal lumen] (R-HSA-5674167) NEU1 L303P [lysosomal lumen] (R-HSA-5674182) NEU1 [extracellular region] (R-HSA-6806158) NEU1 [specific granule lumen] (R-HSA-6806148) NEU1 [lysosomal lumen] (R-HSA-1605788)	0.556	3
UniProt:O60831 PRAF2			0.556	3
UniProt:Q9H2L4 TMM60			0.556	3
UniProt:Q04941 PLP2			0.556	3
UniProt:P11836 CD20			0.556	3
UniProt:Q6PI78 TMM65			0.556	3
UniProt:A0A1P0AYU5 A0A1P0AYU5			0.556	3
UniProt:Q96BI1 SLC22A18	3	SLC22A18 S233F [plasma membrane] (R-HSA-5625564) SLC22A18 R286H [plasma membrane] (R-HSA-5625583) SLC22A18 [plasma membrane] (R-HSA-561110)	0.556	3
UniProt:Q96IW7 SEC22A	3	SEC22A [ER to Golgi transport vesicle membrane] (R-HSA-5688560) SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688562) SEC22A [endoplasmic reticulum membrane] (R-HSA-5216111)	0.556	3
UniProt:Q9P0L0 VAPA	4	VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [cytosol] (R-HSA-9609920) VAPA [plasma membrane] (R-HSA-6806269) VAPA [azurophil granule membrane] (R-HSA-6799364)	0.556	3
UniProt:Q969S6 TM203			0.556	3
UniProt:Q8WWP7 GIMA1			0.556	3
UniProt:Q9UKR5 ERG28			0.556	3
UniProt:Q9Y320 TMX2			0.556	3
UniProt:Q5QGT7 RTP2	1	RTP2 [plasma membrane] (R-HSA-8939446)	0.556	3
UniProt:Q96EC8 YIPF6	2	YIPF6 [cytoplasmic vesicle membrane] (R-HSA-434199) YIPF6 [Golgi membrane] (R-HSA-434346)	0.556	3
UniProt:Q9NWH2 TM242			0.556	3
UniProt:O75427 LRCH4			0.556	3
UniProt:Q96D05-2 FAM241B			0.556	3
UniProt:Q96AG3 S2546			0.556	3
UniProt:Q9UIQ6-2 LNPEP			0.556	3
UniProt:Q9NRZ5 AGPAT4	1	AGPAT4 [endoplasmic reticulum membrane] (R-HSA-61809)	0.556	3
UniProt:Q96LZ7 RMD2			0.556	3
UniProt:Q8N5I4 DHRSX			0.556	3
UniProt:Q69YG0 TMM42			0.556	3
UniProt:Q96MX0 CKLF3			0.556	3
UniProt:Q6ZUI0 TPRG1			0.556	3
UniProt:Q6UX98 ZDH24			0.556	3
UniProt:A0PK00 T120B			0.556	3
UniProt:Q9BUP3-3 HTATIP2			0.556	3
UniProt:Q8N6G5 CSGALNACT2	1	CSGALNACT2 [Golgi membrane] (R-HSA-1971506)	0.556	3
UniProt:O95562 SFT2B			0.556	3
UniProt:Q9NUU6 OTULL			0.556	3
IntAct:EBI-23194662 CCSB ORF ID			0.556	3
UniProt:O15400 STX7			0.556	3
UniProt:Q53HI1 UNC50			0.556	3
UniProt:Q8N2H4 SYS1	1	SYS1 [trans-Golgi network membrane] (R-HSA-6813921)	0.556	3
UniProt:Q8IWU4 SLC30A8	1	SLC30A8 [secretory granule membrane] (R-HSA-437106)	0.556	3
UniProt:Q12981 BNIP1	1	BNIP1 [endoplasmic reticulum membrane] (R-HSA-6810950)	0.556	3
UniProt:P05121 SERPINE1	4	SERPINE1 [platelet alpha granule lumen] (R-HSA-114649) SERPINE1 [plasma membrane] (R-HSA-158922) SERPINE1 [extracellular region] (R-HSA-158797) SERPINE1 [extracellular region] (R-HSA-61271)	0.556	3
UniProt:O75396 SEC22B	6	SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688566) SEC22B [endoplasmic reticulum membrane] (R-HSA-5688150) SEC22B [ER to Golgi transport vesicle membrane] (R-HSA-5688565) SEC22B [phagocytic vesicle membrane] (R-HSA-8863938) SEC22B [transport vesicle] (R-HSA-6810994) SEC22B [Golgi membrane] (R-HSA-6810993)	0.556	3
UniProt:P49638 TTPA	1	TTPA [cytosol] (R-HSA-2980979)	0.556	3
UniProt:Q08426 EHHADH	2	EHHADH [cytosol] (R-HSA-9033147) EHHADH [peroxisomal matrix] (R-HSA-400155)	0.556	3
UniProt:Q15848 ADIPOQ	1	ADIPOQ [extracellular region] (R-HSA-1183052)	0.556	3
UniProt:O95070 YIF1A	1	YIF1A [endoplasmic reticulum membrane] (R-HSA-535599)	0.556	3
UniProt:Q9NRZ7 AGPAT3	2	AGPAT3 [endoplasmic reticulum membrane] (R-HSA-61807) AGPAT3 [Golgi membrane] (R-HSA-8849239)	0.556	3
UniProt:Q13190 STX5	5	STX5 [endoplasmic reticulum membrane] (R-HSA-5689474) STX5 [Golgi membrane] (R-HSA-6807771) STX5 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688157) STX5 [ER to Golgi transport vesicle membrane] (R-HSA-5689838) STX5 [cytosol] (R-HSA-9613991)	0.556	3
UniProt:Q86W74-2 ANKRD46			0.556	3
UniProt:P43378 PTPN9	1	PTPN9 [nucleoplasm] (R-HSA-9008907)	0.556	3
UniProt:P0DN84 DWORF			0.556	3
UniProt:Q5BJH2-2 TMEM128			0.556	3
UniProt:Q9NYZ1 TV23B			0.556	3
UniProt:Q9NRX6 KISHB			0.556	3
UniProt:Q8IV61 RASGRP3	2	p-T133-RASGRP3 [plasma membrane] (R-HSA-1168362) RASGRP3 [cytosol] (R-HSA-1168360)	0.556	3
UniProt:Q9P0S3 ORMDL1	1	ORMDL1 [endoplasmic reticulum membrane] (R-HSA-8865584)	0.556	3
UniProt:Q6ZVE7 GOT1A			0.556	3
UniProt:Q9BQA9 CYBC1			0.556	3
UniProt:Q6FHJ7 SFRP4			0.556	3
UniProt:Q9NUH8 TM14B			0.556	3

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