Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
HSD17B11 [cytosol]
Stable Identifier
R-HSA-5693370
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Estradiol 17-beta-dehydrogenase 11 ecNumber1.1.1.62/ecNumber, DHB11_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Metabolism of steroid hormones (Homo sapiens)
Estrogen biosynthesis (Homo sapiens)
HSD17B11 dehydrogenates EST17b to E1 (Homo sapiens)
HSD17B11 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8NBQ5 HSD17B11
Gene Names
HSD17B11, DHRS8, PAN1B, SDR16C2, PSEC0029, UNQ207/PRO233
Chain
signal peptide:1-19, chain:20-300
Reference Genes
BioGPS Gene:51170 HSD17B11
COSMIC (genes):HSD17B11 HSD17B11
CTD Gene:51170 HSD17B11
dbSNP Gene:51170 HSD17B11
ENSEMBL:ENSG00000198189 HSD17B11
HGNC:22960 HSD17B11
KEGG Gene (Homo sapiens):51170 HSD17B11
Monarch:51170 HSD17B11
NCBI Gene:51170 HSD17B11
OMIM:612831 HSD17B11
UCSC:Q8NBQ5 HSD17B11
Reference Transcript
RefSeq:NM_016245.4 HSD17B11
Other Identifiers
0006400452
11730778_a_at
11757494_s_at
16977820
217989_at
2777071
2777072
2777073
2777074
2777075
2777078
2777085
2777086
2777088
2777091
2777100
2777101
51170
53719_at
8101648
A_23_P21644
A_23_P408271
GE58711
GO:0003674
GO:0004303
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005783
GO:0005811
GO:0005829
GO:0006629
GO:0006694
GO:0006703
GO:0006710
GO:0008150
GO:0009056
GO:0009058
GO:0016229
GO:0016491
GO:0016616
GO:0043226
GO:0044594
GO:0055114
GO:0072582
HMNXSV003020141
ILMN_1675117
ILMN_1722076
ILMN_1735367
PH_hs_0023459
TC04002945.hg
g7705904_3p_at
Inferred To
Dmel\CG17121 [cytosol]
(Drosophila melanogaster)
HSD17B11 [cytosol]
(Bos taurus)
HSD17B11 [cytosol]
(Gallus gallus)
HSD17B11 [cytosol]
(Saccharomyces cerevisiae)
HSD17B11 [cytosol]
(Sus scrofa)
synj2bp [cytosol]
(Xenopus tropicalis)
TDA5 [cytosol]
(Saccharomyces cerevisiae)
firl [cytosol]
(Drosophila melanogaster)
dhs-4 [cytosol]
(Caenorhabditis elegans)
Dmel\CG15629 [cytosol]
(Drosophila melanogaster)
Hsd17b11 [cytosol]
(Mus musculus)
Hsd17b11 [cytosol]
(Rattus norvegicus)
dhs-29 [cytosol]
(Caenorhabditis elegans)
dhs-3 [cytosol]
(Caenorhabditis elegans)
Dmel\CG13833 [cytosol]
(Drosophila melanogaster)
Dmel\CG9265 [cytosol]
(Drosophila melanogaster)
Ldsdh1 [cytosol]
(Drosophila melanogaster)
HSD17B13 [cytosol]
(Canis familiaris)
Homologues of HSD17B11 [cytosol]
(Caenorhabditis elegans)
Homologues of HSD17B11 [cytosol]
(Drosophila melanogaster)
Homologues of HSD17B11 [cytosol]
(Saccharomyces cerevisiae)
SRL4 [cytosol]
(Saccharomyces cerevisiae)
dhs-19 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_057329.3
OpenTargets
ENSG00000198189
GeneCards
Q8NBQ5
HPA
ENSG00000198189-HSD17B11
Ensembl
ENSG00000198189
,
ENST00000358290
,
ENSP00000351035
PRO
Q8NBQ5
Pharos - Targets
Q8NBQ5
PDB
1YB1
HMDB Protein
HMDBP00547
Interactors (60)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6ZPD8 DGAT2L6
1
DGAT2L6 [endoplasmic reticulum membrane]
(R-HSA-8848588)
0.556
3
UniProt:Q99519 NEU1
8
NEU1 W29* [lysosomal lumen]
(R-HSA-5674174)
NEU1 [lysosomal lumen]
(R-HSA-1605788)
NEU1 W23* [lysosomal lumen]
(R-HSA-5674155)
NEU1 [extracellular region]
(R-HSA-6806158)
NEU1 L303P [lysosomal lumen]
(R-HSA-5674182)
NEU1 R225P [lysosomal lumen]
(R-HSA-5674167)
NEU1 [specific granule lumen]
(R-HSA-6806148)
NEU1 E377* [lysosomal lumen]
(R-HSA-5674181)
0.556
3
UniProt:O60831 PRAF2
0.556
3
UniProt:Q9H2L4 TMM60
0.556
3
UniProt:Q04941 PLP2
0.556
3
UniProt:P11836 CD20
0.556
3
UniProt:Q6PI78 TMM65
0.556
3
UniProt:Q08426 EHHADH
2
EHHADH [peroxisomal matrix]
(R-HSA-400155)
EHHADH [cytosol]
(R-HSA-9033147)
0.556
3
UniProt:A0A1P0AYU5 A0A1P0AYU5
0.556
3
UniProt:Q96IW7 SEC22A
3
SEC22A [ER to Golgi transport vesicle membrane]
(R-HSA-5688560)
SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688562)
SEC22A [endoplasmic reticulum membrane]
(R-HSA-5216111)
0.556
3
UniProt:Q9P0L0 VAPA
4
VAPA [plasma membrane]
(R-HSA-6806269)
VAPA [cytosol]
(R-HSA-9609920)
VAPA [endoplasmic reticulum membrane]
(R-HSA-429677)
VAPA [azurophil granule membrane]
(R-HSA-6799364)
0.556
3
UniProt:Q969S6 TM203
0.556
3
UniProt:Q8WWP7 GIMA1
0.556
3
UniProt:Q9UKR5 ERG28
0.556
3
UniProt:Q9Y320 TMX2
0.556
3
UniProt:Q5QGT7 RTP2
0.556
3
UniProt:Q96EC8 YIPF6
2
YIPF6 [Golgi membrane]
(R-HSA-434346)
YIPF6 [cytoplasmic vesicle membrane]
(R-HSA-434199)
0.556
3
UniProt:Q9NWH2 TM242
0.556
3
UniProt:O75427 LRCH4
0.556
3
UniProt:Q96D05-2 FAM241B
0.556
3
UniProt:Q96AG3 S2546
0.556
3
UniProt:Q9UIQ6-2 LNPEP
0.556
3
UniProt:Q9NRZ5 AGPAT4
1
AGPAT4 [endoplasmic reticulum membrane]
(R-HSA-61809)
0.556
3
UniProt:Q96LZ7 RMD2
0.556
3
UniProt:Q8N5I4 DHRSX
0.556
3
UniProt:Q69YG0 TMM42
0.556
3
UniProt:Q96MX0 CKLF3
0.556
3
UniProt:Q6ZUI0 TPRG1
0.556
3
UniProt:Q6UX98 ZDH24
0.556
3
UniProt:A0PK00 T120B
0.556
3
UniProt:Q9BUP3-3 HTATIP2
0.556
3
UniProt:Q8N6G5 CSGALNACT2
1
CSGALNACT2 [Golgi membrane]
(R-HSA-1971506)
0.556
3
UniProt:O95562 SFT2B
0.556
3
UniProt:Q9NUU6 OTULL
0.556
3
IntAct:EBI-23194662 CCSB ORF ID
0.556
3
UniProt:O15400 STX7
0.556
3
UniProt:Q53HI1 UNC50
0.556
3
UniProt:Q9NUH8 TM14B
0.556
3
UniProt:Q96BI1 SLC22A18
3
SLC22A18 [plasma membrane]
(R-HSA-561110)
SLC22A18 R286H [plasma membrane]
(R-HSA-5625583)
SLC22A18 S233F [plasma membrane]
(R-HSA-5625564)
0.556
3
UniProt:Q8IWU4 SLC30A8
1
SLC30A8 [secretory granule membrane]
(R-HSA-437106)
0.556
3
UniProt:O95070 YIF1A
1
YIF1A [endoplasmic reticulum membrane]
(R-HSA-535599)
0.556
3
UniProt:Q9NRZ7 AGPAT3
2
AGPAT3 [endoplasmic reticulum membrane]
(R-HSA-61807)
AGPAT3 [Golgi membrane]
(R-HSA-8849239)
0.556
3
UniProt:P05121 SERPINE1
4
SERPINE1 [extracellular region]
(R-HSA-61271)
SERPINE1 [extracellular region]
(R-HSA-158797)
SERPINE1 [plasma membrane]
(R-HSA-158922)
SERPINE1 [platelet alpha granule lumen]
(R-HSA-114649)
0.556
3
UniProt:Q15848 ADIPOQ
1
ADIPOQ [extracellular region]
(R-HSA-1183052)
0.556
3
UniProt:Q13190 STX5
5
STX5 [Golgi membrane]
(R-HSA-6807771)
STX5 [cytosol]
(R-HSA-9613991)
STX5 [ER to Golgi transport vesicle membrane]
(R-HSA-5689838)
STX5 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688157)
STX5 [endoplasmic reticulum membrane]
(R-HSA-5689474)
0.556
3
UniProt:Q12981 BNIP1
1
BNIP1 [endoplasmic reticulum membrane]
(R-HSA-6810950)
0.556
3
UniProt:Q8N2H4 SYS1
1
SYS1 [trans-Golgi network membrane]
(R-HSA-6813921)
0.556
3
UniProt:O75396 SEC22B
6
SEC22B [ER to Golgi transport vesicle membrane]
(R-HSA-5688565)
SEC22B [endoplasmic reticulum membrane]
(R-HSA-5688150)
SEC22B [transport vesicle]
(R-HSA-6810994)
SEC22B [phagocytic vesicle membrane]
(R-HSA-8863938)
SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688566)
SEC22B [Golgi membrane]
(R-HSA-6810993)
0.556
3
UniProt:P49638 TTPA
1
TTPA [cytosol]
(R-HSA-2980979)
0.556
3
UniProt:Q86W74-2 ANKRD46
0.556
3
UniProt:P43378 PTPN9
1
PTPN9 [nucleoplasm]
(R-HSA-9008907)
0.556
3
UniProt:P0DN84 DWORF
0.556
3
UniProt:Q5BJH2-2 TMEM128
0.556
3
UniProt:Q9NYZ1 TV23B
0.556
3
UniProt:Q9NRX6 KISHB
0.556
3
UniProt:Q8IV61 RASGRP3
2
RASGRP3 [cytosol]
(R-HSA-1168360)
p-T133-RASGRP3 [plasma membrane]
(R-HSA-1168362)
0.556
3
UniProt:Q9P0S3 ORMDL1
1
ORMDL1 [endoplasmic reticulum membrane]
(R-HSA-8865584)
0.556
3
UniProt:Q6ZVE7 GOT1A
0.556
3
UniProt:Q9BQA9 CYBC1
0.556
3
UniProt:Q6FHJ7 SFRP4
0.556
3
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
