Reactome | GJB5 [endoplasmic reticulum membrane]

GJB5 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-190643

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Connexin 31.1

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Gap junction trafficking and regulation (Homo sapiens)
    - Gap junction trafficking (Homo sapiens)
      - Gap junction assembly (Homo sapiens)
        
        Connexin synthesis (generic) (Homo sapiens)
        
        Monomeric connexin protein [endoplasmic reticulum membrane] (Homo sapiens)
        
        GJB5 [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95377 GJB5

Gene Names

GJB5

Chain

chain:1-273

Reference Genes

BioGPS Gene:2709 GJB5

COSMIC (genes):GJB5 GJB5

CTD Gene:2709 GJB5

dbSNP Gene:2709 GJB5

ENSEMBL:ENSG00000189280 GJB5

HGNC:4287 GJB5

KEGG Gene (Homo sapiens):2709 GJB5

Monarch:2709 GJB5

NCBI Gene:2709 GJB5

OMIM:604493 GJB5

UCSC:O95377 GJB5

Reference Transcript

Other Identifiers

0002060465

11726877_at

16662313

206156_at

2709

38903_at

4054438

4054439

4054440

4054441

7899921

A_23_P35293

GE62573

GO:0000003

GO:0003674

GO:0005243

GO:0005515

GO:0005575

GO:0005886

GO:0005921

GO:0005922

GO:0006810

GO:0007154

GO:0007267

GO:0008150

GO:0008544

GO:0009790

GO:0016020

GO:0016021

GO:0022857

GO:0030054

GO:0030154

GO:0032991

GO:0048856

GO:0055085

GO:0060707

GO:0060708

GO:0060713

GO:1905867

HMNXSV003006459

ILMN_1735365

PH_hs_0011677

TC01000448.hg

g10835078_3p_at

Participates

as a candidate of

Monomeric connexin protein [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

Gjb5 [endoplasmic reticulum membrane] (Mus musculus)

Gjb5 [endoplasmic reticulum membrane] (Rattus norvegicus)

LOC102151297 [endoplasmic reticulum membrane] (Canis familiaris)

GJB5 [endoplasmic reticulum membrane] (Gallus gallus)

GJB5 [endoplasmic reticulum membrane] (Sus scrofa)

gjb4 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Cross References

RefSeq

XP_005270808.1, NP_005259.1

Guide to Pharmacology - Targets

721

OpenTargets

ENSG00000189280

HPA

ENSG00000189280-GJB5

GeneCards

O95377

Ensembl

ENSP00000340811, ENST00000338513, ENSG00000189280

PRO

O95377

Pharos - Targets

O95377

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8IY26 PLPP6	1	PLPP6 [plasma membrane] (R-HSA-8952144)	0.556	3
UniProt:O75396 SEC22B	6	SEC22B [ER to Golgi transport vesicle membrane] (R-HSA-5688565) SEC22B [endoplasmic reticulum membrane] (R-HSA-5688150) SEC22B [transport vesicle] (R-HSA-6810994) SEC22B [phagocytic vesicle membrane] (R-HSA-8863938) SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688566) SEC22B [Golgi membrane] (R-HSA-6810993)	0.556	3
UniProt:P21964 COMT	2	COMT [cytosol] (R-HSA-175974) COMT [plasma membrane] (R-HSA-379386)	0.556	3
UniProt:Q9Y6X1 SERP1	2	SERP1 [cytosol] (R-HSA-5250574) SERP1 [endoplasmic reticulum membrane] (R-HSA-381045)	0.556	3
UniProt:Q9BRI3 SLC30A2	2	SLC30A2 [endosome membrane] (R-HSA-435363) SLC30A2 [synaptic vesicle membrane] (R-HSA-4084714)	0.556	3
UniProt:P24593 IGFBP5	5	IGFBP5 [endoplasmic reticulum lumen] (R-HSA-8956738) IGFBP5(164-272) [extracellular region] (R-HSA-381478) p-IGFBP5 [endoplasmic reticulum lumen] (R-HSA-8956988) IGFBP5 [extracellular region] (R-HSA-381414) IGFBP5(21-163) [extracellular region] (R-HSA-381415)	0.556	3

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