Reactome | IFNGR2 [plasma membrane]

IFNGR2 [plasma membrane]

Stable Identifier

R-HSA-629620

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Interferon gamma receptor 2, INGR2_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - SARS-CoV Infections (Homo sapiens)
    - Potential therapeutics for SARS (Homo sapiens)
      - IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Homo sapiens)
        
        IFNGR1:JAK1:INFGR2:JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
        
        IFNGR1:JAK1:INFGR2:JAK2:JAK1,2 inhibitors [plasma membrane] (Homo sapiens)
        
        IFNGR1:JAK1:INFGR2:JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Interferon Signaling (Homo sapiens)
    - Interferon gamma signaling (Homo sapiens)
      - Binding of STAT1 to p-IFNGR1 (Homo sapiens)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
        
        STAT1 bound to p-IFNGR1 [plasma membrane] (Homo sapiens)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
      - IFNG dimer binds IFNGR (Homo sapiens)
        
        IFNG:IFNGR1:JAK1:IFNGR2:JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR1:JAK1:INFGR2:JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
        
        IFNGR1:JAK1:INFGR2:JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
      - IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Homo sapiens)
        
        IFNGR1:JAK1:INFGR2:JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
        
        IFNGR1:JAK1:INFGR2:JAK2:JAK1,2 inhibitors [plasma membrane] (Homo sapiens)
        
        IFNGR1:JAK1:INFGR2:JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
      - Phosphorylation of IFNGR1 by JAK kinases (Homo sapiens)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR complex with p-JAK [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
      - Phosphorylation of JAK2 (Homo sapiens)
        
        IFNG:IFNGR1:JAK1:IFNGR2:JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR1:JAK1:INFGR2:JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR complex with p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
      - Phosphorylation of STAT1 at Ser727 (Homo sapiens)
        
        p-STAT1 dimer bound to p-IFNGR1 [plasma membrane] (Homo sapiens)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
        
        p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane] (Homo sapiens)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
      - Phosphorylation of STAT1 by JAK kinases (Homo sapiens)
        
        STAT1 bound to p-IFNGR1 [plasma membrane] (Homo sapiens)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
        
        p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane] (Homo sapiens)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
      - Regulation of IFNG signaling (Homo sapiens)
        
        Dephosphorylation of JAKs by PTPs (Homo sapiens)
        
        IFNG:IFNGR1:JAK1:IFNGR2:JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR1:JAK1:INFGR2:JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR complex with p-JAK [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
        
        SOCS-1 and SOCS-3 binds to p-JAK2 (Homo sapiens)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR complex with p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Homo sapiens)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR complex with p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
      - Release of STAT1 dimer from active receptor unit (Homo sapiens)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
        
        p-STAT1 dimer bound to p-IFNGR1 [plasma membrane] (Homo sapiens)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
      - Transphosphorylation of JAK1 (Homo sapiens)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR complex with p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Homo sapiens)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR complex with p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR complex with p-JAK [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P38484 IFNGR2

Gene Names

IFNGR2, IFNGT1

Chain

signal peptide:1-21, chain:22-337

Reference Genes

BioGPS Gene:3460 IFNGR2

COSMIC (genes):IFNGR2 IFNGR2

CTD Gene:3460 IFNGR2

dbSNP Gene:3460 IFNGR2

ENSEMBL:ENSG00000159128 IFNGR2

ENSEMBL:ENSG00000159128.16 IFNGR2

ENSEMBL:ENSG00000262795.5 IFNGR2

HGNC:5440 IFNGR2

KEGG Gene (Homo sapiens):3460 IFNGR2

Monarch:3460 IFNGR2

NCBI Gene:3460 IFNGR2

OMIM:147569 IFNGR2

UCSC:P38484 IFNGR2

Reference Transcript

RefSeq:NM_005534.3 IFNGR2

Other Identifiers

0005360731

11715532_a_at

16922275

201642_PM_at

201642_at

3460

3918639

3918640

3918642

3918645

3918648

3918650

3918654

3918660

3918661

41140_at

75317_s_at

8068280

A_14_P120732

A_23_P29036

GE61247

GO:0000139

GO:0001774

GO:0002376

GO:0004896

GO:0004906

GO:0005515

GO:0005622

GO:0005737

GO:0005783

GO:0005789

GO:0005794

GO:0005886

GO:0005887

GO:0006954

GO:0007166

GO:0009615

GO:0016020

GO:0016021

GO:0019221

GO:0023052

GO:0030659

GO:0031410

GO:0043226

GO:0051607

GO:0055085

GO:0060089

GO:0060333

GO:0098542

GO:0098586

GO:1904783

HMNXSV003052949

ILMN_1764964

PH_hs_0024785

TC21000129.hg

U05875_at

g5031782_3p_at

Participates

as a component of

Inferred To

Ifngr2 [plasma membrane] (Mus musculus)

Ifngr2 [plasma membrane] (Rattus norvegicus)

Homologues of IFNGR2 [plasma membrane] (Danio rerio)

Homologues of IFNGR2 [plasma membrane] (Xenopus tropicalis)

IFNGR2 [plasma membrane] (Bos taurus)

IFNGR2 [plasma membrane] (Canis familiaris)

IFNGR2 [plasma membrane] (Danio rerio)

IFNGR2 [plasma membrane] (Gallus gallus)

IFNGR2 [plasma membrane] (Sus scrofa)

ifngr2.2 [plasma membrane] (Xenopus tropicalis)

il10rb [plasma membrane] (Xenopus tropicalis)

ifngr2.1 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_005525.2

Guide to Pharmacology - Targets

1726

OpenTargets

ENSG00000159128

HPA

ENSG00000159128-IFNGR2

GeneCards

P38484

Ensembl

ENSP00000458487, ENST00000290219, ENSP00000290219, ENSG00000159128, ENSG00000262795, ENST00000576463

PRO

P38484

Pharos - Targets

P38484

Orphanet

16243

PDB

5EH1, 6E3K, 6E3L

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5QGT7 RTP2	2	RTP2 [endoplasmic reticulum membrane] (R-HSA-9752982) RTP2 [plasma membrane] (R-HSA-8939446)	0.556	3
UniProt:Q01453 PMP22	1	PMP22 [plasma membrane] (R-HSA-9615623)	0.556	3
UniProt:O75396 SEC22B	6	SEC22B [endoplasmic reticulum membrane] (R-HSA-5688150) SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688566) SEC22B [ER to Golgi transport vesicle membrane] (R-HSA-5688565) SEC22B [phagocytic vesicle membrane] (R-HSA-8863938) SEC22B [transport vesicle] (R-HSA-6810994) SEC22B [Golgi membrane] (R-HSA-6810993)	0.556	3
UniProt:Q15848 ADIPOQ	1	ADIPOQ [extracellular region] (R-HSA-1183052)	0.556	3
UniProt:P11686 SFTPC	9	pro-SFTPC P115L [endoplasmic reticulum membrane] (R-HSA-5688352) pro-SFTPC P30L [endoplasmic reticulum membrane] (R-HSA-5688365) pro-SFTPC [endoplasmic reticulum membrane] (R-HSA-5683842) pro-SFTPC [multivesicular body lumen] (R-HSA-5685298) SFTPC [extracellular region] (R-HSA-5683685) SFTPC [clathrin-coated endocytic vesicle] (R-HSA-5686342) SFTPC [lamellar body] (R-HSA-5683717) SFTPC(24-58) [multivesicular body lumen] (R-HSA-5685899) SFTPC(59-197) [multivesicular body lumen] (R-HSA-5685871)	0.556	3
UniProt:P13861 PRKAR2A	2	PRKAR2A [cytosol] (R-HSA-57840) PRKAR2A [ciliary base] (R-HSA-5610412)	0.463	2

Cite Us!