Reactome | IFNGR2 [plasma membrane]

IFNGR2 [plasma membrane]

Stable Identifier

R-HSA-629620

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Interferon gamma receptor 2, INGR2_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Interferon Signaling (Homo sapiens)
    - Interferon gamma signaling (Homo sapiens)
      - Binding of STAT1 to p-IFNGR1 (Homo sapiens)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
        
        STAT1 bound to p-IFNGR1 [plasma membrane] (Homo sapiens)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
      - Interaction of IFNG with IFNGR (Homo sapiens)
        
        IFNG:IFNGR1:JAK1:IFNGR2:JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR1:JAK1:INFG2:JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
        
        IFNGR1:JAK1:INFG2:JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
      - Phosphorylation of IFNGR1 by JAK kinases (Homo sapiens)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR complex with p-JAK [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
      - Phosphorylation of JAK2 (Homo sapiens)
        
        IFNG:IFNGR1:JAK1:IFNGR2:JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR1:JAK1:INFG2:JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR complex with p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
      - Phosphorylation of STAT1 at Ser727 (Homo sapiens)
        
        p-STAT1 dimer bound to p-IFNGR1 [plasma membrane] (Homo sapiens)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
        
        p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane] (Homo sapiens)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
      - Phosphorylation of STAT1 by JAK kinases (Homo sapiens)
        
        STAT1 bound to p-IFNGR1 [plasma membrane] (Homo sapiens)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
        
        p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane] (Homo sapiens)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
      - Regulation of IFNG signaling (Homo sapiens)
        
        Dephosphorylation of JAKs by PTPs (Homo sapiens)
        
        IFNG:IFNGR1:JAK1:IFNGR2:JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR1:JAK1:INFG2:JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR complex with p-JAK [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
        
        SOCS-1 and SOCS-3 binds to p-JAK2 (Homo sapiens)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR complex with p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Homo sapiens)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR complex with p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
      - Release of STAT1 dimer from active receptor unit (Homo sapiens)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
        
        p-STAT1 dimer bound to p-IFNGR1 [plasma membrane] (Homo sapiens)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
      - Transphosphorylation of JAK1 (Homo sapiens)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR complex with p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Homo sapiens)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR complex with p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR complex with p-JAK [plasma membrane] (Homo sapiens)
        
        IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IFNGR2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P38484 IFNGR2

Gene Names

IFNGR2, IFNGT1

Chain

signal peptide:1-21, chain:22-337

Reference Genes

BioGPS Gene:3460 IFNGR2

COSMIC (genes):IFNGR2 IFNGR2

CTD Gene:3460 IFNGR2

dbSNP Gene:3460 IFNGR2

ENSEMBL:ENSG00000159128 IFNGR2

ENSEMBL:ENSG00000262795 IFNGR2

HGNC:5440 IFNGR2

KEGG Gene (Homo sapiens):3460 IFNGR2

Monarch:3460 IFNGR2

NCBI Gene:3460 IFNGR2

OMIM:147569 IFNGR2

UCSC:P38484 IFNGR2

Reference Transcript

RefSeq:NM_005534.3 IFNGR2

Other Identifiers

0005360731

11715532_a_at

1535

16922275

201642_at

3460

3918636

3918637

3918638

3918639

3918640

3918642

3918645

3918648

3918650

3918654

3918660

3918661

41140_at

5EH1

6E3K

6E3L

75317_s_at

8068280

A0A0G2JLE8

A8K881

A_14_P120732

A_23_P29036

AAA16955

AAA16956

AAC52066

AAH03624

AAT45458

AK292246

AK314005

AY644470

B5MCZ0

BAF84935

BAG36717

BC003624

CCDS33544

CH471079

E7EUY1

EAX09834

ENSG00000159128

ENSG00000262795

ENSP00000290219

ENSP00000371425

ENSP00000458487

ENST00000290219

ENST00000290219.10

ENST00000381995

ENST00000576463

EntrezGene:3460

EntrezGene:IFNGR2

F8WE34

F8WF11

g5031782_3p_at

GE61247

GO:0000139

GO:0002376

GO:0003674

GO:0004896

GO:0004906

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005783

GO:0005789

GO:0005794

GO:0005886

GO:0005887

GO:0006950

GO:0007165

GO:0007166

GO:0008150

GO:0009615

GO:0016020

GO:0016021

GO:0019221

GO:0030659

GO:0031410

GO:0043226

GO:0060333

GO:0060334

HGNC:5440

HPA001535

IFNGR2

IFNGR2-201

IFNGR2-212

ILMN_1764964

IPR003961

IPR013783

IPR015373

IPR036116

LRG_67

LRG_67t1

MIM:147569

MIM:614889

NM_005534

NP_005525

PF01108

PF09294

PH_hs_0024785

TC21000129.hg

U05875

U05875_at

U05877

U68755

UPI00001514B0

UPI00046209FA

XM_011529554

XP_011527856

Participant Of

hasComponent

Inferred To

Homologues of IFNGR2 [plasma membrane] (Canis familiaris)

Homologues of IFNGR2 [plasma membrane] (Danio rerio)

Homologues of IFNGR2 [plasma membrane] (Xenopus tropicalis)

IFNGR2 [plasma membrane] (Bos taurus)

IFNGR2 [plasma membrane] (Canis familiaris)

IFNGR2 [plasma membrane] (Danio rerio)

IFNGR2 [plasma membrane] (Gallus gallus)

IFNGR2 [plasma membrane] (Mus musculus)

IFNGR2 [plasma membrane] (Rattus norvegicus)

IFNGR2 [plasma membrane] (Sus scrofa)

IFNGR2 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_005525.2

OpenTargets

ENSG00000159128

GeneCards

P38484

PRO

P38484

Orphanet

16243

PDB

6E3K, 5EH1, 6E3L

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11686 SFTPC	9	pro-SFTPC P30L [endoplasmic reticulum membrane] (R-HSA-5688365) pro-SFTPC P115L [endoplasmic reticulum membrane] (R-HSA-5688352) pro-SFTPC [endoplasmic reticulum membrane] (R-HSA-5683842) pro-SFTPC [multivesicular body lumen] (R-HSA-5685298) SFTPC [extracellular region] (R-HSA-5683685) SFTPC [clathrin-coated endocytic vesicle] (R-HSA-5686342) SFTPC [lamellar body] (R-HSA-5683717) SFTPC(24-58) [multivesicular body lumen] (R-HSA-5685899) SFTPC(59-197) [multivesicular body lumen] (R-HSA-5685871)	0.488	2
UniProt:O75396 SEC22B	6	SEC22B [endoplasmic reticulum membrane] (R-HSA-5688150) SEC22B [ER to Golgi transport vesicle membrane] (R-HSA-5688565) SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688566) SEC22B [phagocytic vesicle membrane] (R-HSA-8863938) SEC22B [transport vesicle] (R-HSA-6810994) SEC22B [Golgi membrane] (R-HSA-6810993)	0.488	2
UniProt:Q15848 ADIPOQ	1	ADIPOQ [extracellular region] (R-HSA-1183052)	0.488	2