Reactome | HIBADH [mitochondrial matrix]

HIBADH [mitochondrial matrix]

Stable Identifier

R-HSA-70882

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

3-hydroxyisobutyrate dehydrogenase, monomer, D3HI_HUMAN, 3-hydroxyisobutyrate dehydrogenase, mitochondrial precursor

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P31937 HIBADH

Gene Names

HIBADH

Chain

transit peptide:1-36, chain:37-336

Reference Genes

BioGPS Gene:11112 HIBADH

COSMIC (genes):HIBADH HIBADH

CTD Gene:11112 HIBADH

dbSNP Gene:11112 HIBADH

ENSEMBL:ENSG00000106049 HIBADH

ENSEMBL_homo_sapiens_GENE:ENSG00000106049.9 HIBADH

HGNC:4907 HIBADH

KEGG Gene (Homo sapiens):11112 HIBADH

Monarch:11112 HIBADH

NCBI Gene:11112 HIBADH

OMIM:608475 HIBADH

UCSC:P31937 HIBADH

Reference Transcript

RefSeq:NM_152740.3 HIBADH

Other Identifiers

11112

11716211_a_at

11716212_a_at

17056211

224812_PM_at

224812_at

231955_PM_s_at

231955_s_at

3043166

3043167

3043168

3043172

3043179

3043183

3043208

3043209

3043210

3043213

3043221

55758_at

8138776

A_23_P335428

GE62846

GO:0003824

GO:0005515

GO:0005739

GO:0005759

GO:0006520

GO:0006574

GO:0008442

GO:0009083

GO:0016491

GO:0016616

GO:0043226

GO:0050661

GO:0051287

HMNXSV003021980

Hs.284170.0.S1_3p_at

Hs.284170.2.S1_3p_a_at

ILMN_1804150

PH_hs_0014715

TC07001230.hg

Participates

as a component of

HIBADH tetramer [mitochondrial matrix] (Homo sapiens)

Inferred To

hibadh [mitochondrial matrix] (Danio rerio)

hibadh [mitochondrial matrix] (Xenopus tropicalis)

HIBADH [mitochondrial matrix] (Bos taurus)

HIBADH [mitochondrial matrix] (Caenorhabditis elegans)

HIBADH [mitochondrial matrix] (Canis familiaris)

HIBADH [mitochondrial matrix] (Dictyostelium discoideum)

HIBADH [mitochondrial matrix] (Drosophila melanogaster)

HIBADH [mitochondrial matrix] (Gallus gallus)

HIBADH [mitochondrial matrix] (Mus musculus)

HIBADH [mitochondrial matrix] (Rattus norvegicus)

HIBADH [mitochondrial matrix] (Sus scrofa)

Cross References

RefSeq

NP_689953.1

OpenTargets

ENSG00000106049

GeneCards

P31937

HPA

ENSG00000106049-HIBADH

Ensembl

ENST00000265395, ENSG00000106049, ENSP00000265395

PRO

P31937

Pharos - Targets

P31937

HMDB Protein

HMDBP00395

PDB

2GF2, 2I9P

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14653 GOSR2	4	GOSR2 [Golgi membrane] (R-HSA-6807755) GOSR2 [endoplasmic reticulum membrane] (R-HSA-5689451) GOSR2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-535472) GOSR2 [ER to Golgi transport vesicle membrane] (R-HSA-5689800)	0.556	3
UniProt:O95674 CDS2	1	CDS2 [mitochondrial inner membrane] (R-HSA-1498755)	0.556	3
UniProt:Q8N661 TMEM86B	1	TMEM86B [endoplasmic reticulum membrane] (R-HSA-8874443)	0.556	3
UniProt:O75396 SEC22B	6	SEC22B [endoplasmic reticulum membrane] (R-HSA-5688150) SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688566) SEC22B [ER to Golgi transport vesicle membrane] (R-HSA-5688565) SEC22B [phagocytic vesicle membrane] (R-HSA-8863938) SEC22B [transport vesicle] (R-HSA-6810994) SEC22B [Golgi membrane] (R-HSA-6810993)	0.556	3
UniProt:Q5QGT7 RTP2	2	RTP2 [endoplasmic reticulum membrane] (R-HSA-9752982) RTP2 [plasma membrane] (R-HSA-8939446)	0.556	3
UniProt:P21964 COMT	2	COMT [plasma membrane] (R-HSA-379386) COMT [cytosol] (R-HSA-175974)	0.556	3
UniProt:P63027 VAMP2	20	VAMP2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869129) VAMP2 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-379363) VAMP2 [plasma membrane] (R-HSA-210516) VAMP2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917738) VAMP2 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-210365) VAMP2 [synaptic vesicle membrane] (R-HSA-181517) VAMP2(59-116) [synaptic vesicle membrane] (R-HSA-5250891) VAMP2(2-58) [cytosol] (R-HSA-194815) VAMP2(2-76) [cytosol] (R-HSA-194802) VAMP2(77-116) [synaptic vesicle membrane] (R-HSA-5228355) VAMP2(60-116) [synaptic vesicle membrane] (R-HSA-5250615) VAMP2(2-59) [cytosol] (R-HSA-194797) VAMP2(82-116) [synaptic vesicle membrane] (R-HSA-5250961) VAMP2(2-81) [cytosol] (R-HSA-5250970) VAMP2 [secretory granule membrane] (R-HSA-376363) VAMP2 [cytosol] (R-HSA-9609882) VAMP2 [endoplasmic reticulum membrane] (R-HSA-9609886) VAMP2 [cytoplasmic vesicle membrane] (R-HSA-1449630) VAMP2 [lysosomal membrane] (R-HSA-432703) VAMP2 [Golgi membrane] (R-HSA-375425)	0.556	3
UniProt:Q9Y5Z9 UBIAD1	1	UBIAD1 [endoplasmic reticulum membrane] (R-HSA-2980965)	0.556	3

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