SEC22B, CALR, STX4, TAP and TAPBP bind

Stable Identifier
R-HSA-8863858
Type
Reaction [binding]
Species
Homo sapiens
Compartment
endoplasmic reticulum-Golgi intermediate compartment membrane, phagocytic vesicle membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SEC22B, CALR, STX4, TAP and TAPBP bind
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The interaction between the two compartments could involve either direct fusion of ER stacks to phagosomes (Phgs) or vesicular intermediates. In both cases, a fusion event between the ER or ER-derived membrane vesicles and Phgs must occur. The SNARE SEC22B localizes to the ER-Golgi intermediate compartment (ERGIC) and interacts with SNARE syntaxin 4 (STX4) on phagosomes (Phgs), mediating the recruitment of subset of ER components including transporter associated with antigen processing (TAP), to phagosomes (Cebrian et al. 2011).
Literature References
PubMed ID Title Journal Year
22153078 Sec22b regulates phagosomal maturation and antigen crosspresentation by dendritic cells

Cebrian, I, Visentin, G, Blanchard, N, Jouve, M, Bobard, A, Moita, C, Enninga, J, Moita, LF, Amigorena, S, Savina, A

Cell 2011
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane (1990668)
Authored
Garapati, P V  (2016-03-10)
Reviewed
Bergeron, JJ  (2016-05-16)
Created
Garapati, P V  (2016-03-10)
Cite Us!